Patents by Inventor Rajeev Sivasankaran

Rajeev Sivasankaran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REGULATABLE EXPRESSION SYSTEMS
    Publication number: 20220307053
    Abstract: Provided herein are compositions comprising minigenes comprising splice modulator binding sequences, for regulatable gene expression, and systems and methods of use thereof.
    Type: Application
    Filed: July 24, 2020
    Publication date: September 29, 2022
    Inventors: Martin BEIBEL, Caroline Gubser KELLER, Dmitriy LUKASHEV, Nicole RENAUD, Nikita RUDINSKIY, Rajeev SIVASANKARAN
  • Use of Trifluoromethyl Substituted Benzamides in teh Treatment of Neurological Disorders
    Publication number: 20090306083
    Abstract: The invention relates to methods of using the compounds of the invention, including trifluoromethyl substituted benzamide compounds and salts thereof, as well as pharmaceutical compositions comprising the same, in the treatment of Eph receptor-related (e.g., neurological) injuries and disorders. The invention also relates to modulating the activity of an Eph receptor in a cell, stimulating neural regeneration, and reversing neuronal degeneration, by administering a compound of the invention to a cell or subject in an effective amount.
    Type: Application
    Filed: July 11, 2007
    Publication date: December 10, 2009
    Inventors: Rajeev Sivasankaran, Kaspar Zimmermann
  • Use of Pyrazolo(1,5A)Pyrimidin-7-YL Amine Derivatives in the Treatment of Neurological Disorders
    Publication number: 20090069315
    Abstract: The invention relates to methods of using the compounds of the invention, including pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof, as well as pharmaceutical compositions comprising the same, in the treatment of Eph receptor-related (e.g., neurological) injuries and disorders. The invention also relates to modulating the activity of an Eph receptor in a cell, stimulating neural regeneration, and reversing neuronal degeneration, by administering a compound of the invention to a cell or subject in an effective amount.
    Type: Application
    Filed: March 6, 2007
    Publication date: March 12, 2009
    Inventors: Rajeev Sivasankaran, Kaspar Zimmermann
  • Axon regeneration with PKC inhibitors
    Publication number: 20050130877
    Abstract: Regenerative growth of an adult mammalian central nervous system neuron axon subject to growth inhibition by endogenous, myelin growth repulsion factors is promoted by delivering to the axon a therapeutically effective amount of a specific inhibitor of protein kinase C, whereby regenerative growth of the axon is promoted and a resultant promotion of the regenerative growth of the axon is detected.
    Type: Application
    Filed: November 9, 2004
    Publication date: June 16, 2005
    Inventors: Zhigang He, Vuk Koprivica, Rajeev Sivasankaran
  • Axon regeneration with PKC inhibitors
    Patent number: 6815450
    Abstract: Regenerative growth of an adult mammalian central nervous system neuron axon subject to growth inhibition by endogenous, myelin growth repulsion factors is promoted by delivering to the axon a therapeutically effective amount of a specific inhibitor of protein kinase C, whereby regenerative growth of the axon is promoted and a resultant promotion of the regenerative growth of the axon is detected.
    Type: Grant
    Filed: March 14, 2003
    Date of Patent: November 9, 2004
    Assignee: Children's Medical Center Corporation
    Inventors: Zhigang He, Vuk Koprivica, Rajeev Sivasankaran
  • Axon regeneration with PKC inhibitiors
    Patent number: 6664266
    Abstract: Regenerative growth of an adult mammalian central nervous system neuron axon subject to growth inhibition by endogenous, myelin growth repulsion factors is promoted by delivering to the axon a therapeutically effective amount of a specific inhibitor of protein kinase C, whereby regenerative growth of the axon is promoted and a resultant promotion of the regenerative growth of the axon is detected.
    Type: Grant
    Filed: March 14, 2002
    Date of Patent: December 16, 2003
    Assignee: Children's Medical Center Corporation
    Inventors: Zhigang He, Vuk Koprivica, Rajeev Sivasankaran
  • Axon regeneration with PKC inhibitors
    Publication number: 20030176424
    Abstract: Regenerative growth of an adult mammalian central nervous system neuron axon subject to growth inhibition by endogenous, myelin growth repulsion factors is promoted by delivering to the axon a therapeutically effective amount of a specific inhibitor of protein kinase C, whereby regenerative growth of the axon is promoted and a resultant promotion of the regenerative growth of the axon is detected.
    Type: Application
    Filed: March 14, 2003
    Publication date: September 18, 2003
    Applicant: Children's Medical Center Corporation
    Inventors: Zhigang He, Vuk Koprivica, Rajeev Sivasankaran
  • AXON REGENERATION WITH PKC INHIBITIORS
    Publication number: 20030176423
    Abstract: Regenerative growth of an adult mammalian central nervous system neuron axon subject to growth inhibition by endogenous, myelin growth repulsion factors is promoted by delivering to the axon a therapeutically effective amount of a specific inhibitor of protein kinase C, whereby regenerative growth of the axon is promoted and a resultant promotion of the regenerative growth of the axon id detected.
    Type: Application
    Filed: March 14, 2002
    Publication date: September 18, 2003
    Applicant: Children's Medical Center Corporation
    Inventors: Zhigang He, Vuk Koprivica, Rajeev Sivasankaran