Abstract: According to some embodiments, a system for fractionally treating tissue includes: an electromagnetic radiation (EMR) source configured to generate an EMR beam having a transverse ring energy profile; an optic configured to converge the EMR beam to a focal region located within a tissue; and, a window assembly located down-beam from the optic configured to cool the tissue when placed in contact with an outer surface of the tissue.

Abstract: A system includes a focus optic configured to converge an electromagnetic radiation (EMR) beam to a focal region located along an optical axis. The system also includes a detector configured to detect a signal radiation emanating from a predetermined location along the optical axis. The system additionally includes a controller configured to adjust a parameter of the EMR beam based in part on the signal radiation detected by the detector. The system also includes a window located a predetermined depth away from the focal region, between the focal region and the focus optic along the optical axis, wherein the window is configured to make contact with a surface of a tissue.

Abstract: The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.

Abstract: A method may include: introducing a silane based aqueous soluble resin into a wellbore, wherein the silane based aqueous soluble resin comprises a glycidyl alkoxy silane containing resin and an amino alkoxy silane hardener. The silane based aqueous soluble resin may include 3-glycidoxypropyl trimethoxy silane and n-(3-(trimethoxysilyl)propyl)ethylenediamine.

Abstract: A method of playing media content in a telecommunication network is disclosed. The method involves uploading media content on a server (100) by a caller device (400). The method further includes selecting at least one callee device (500) from a contact list of the device (400) via a predefined application (300). Further, the method includes forwarding the content from the server to a selected callee device (500). The method is followed by outputting the content by the application (300) on the selected device (500). The content is selected by the device (400), and the content is output at least one of when the selected device (500) is receiving a call from the device (400) or the selected device (500) is commencing the call to the device (400), the content being played on the selected device (500) by capturing ring signal via a ring signal capturing module (250).

Abstract: A method, apparatus, and computer program product for executing a relational database management system (RDBMS) in a computer system, wherein the RDBMS manages a relational database comprised of at least one column-partitioned base table storing data. Column values from at least one column of the column-partitioned base table are stored in one or more containers spread across one or more data blocks. Metadata comprising summarized information about the column values in the containers is stored in a metadata index subtable. A query with a filtering condition on the column is applied to the metadata index subtable before the column-partitioned base table is accessed, so that only qualified containers and data blocks are accessed, and unqualified containers and data blocks are eliminated, when responding to the query.

Abstract: This disclosure relates generally to the preparation of eco-friendly engineered fabric, and more particularly to terry fabric and variations thereof. In one embodiment, a terry fabric is comprised of a soluble fiber blend, blended with cotton fibers, where the soluble fibers are dissolved in a caustic or enzyme solution to create highly porous yarns.

Abstract: A virtual computer system service receives a request from a customer to provision a dedicated server for the exclusive use of the customer. The dedicated server may be used to launch one or more virtual machine instances. The virtual computer system service subsequently selects, from a pool of available servers, a server that can be dedicated to the customer and that does not have capacity allocated to any other customer. The virtual computer system service may update a database to specify, in an entry corresponding to the selected server, that the server has been dedicated for the exclusive use of the customer. Once the database has been updated, the virtual computer system service will enable the customer to launch a virtual machine instance using the dedicated server.

Abstract: A terry article includes a ground component including a plurality of ground warp yarns and a plurality of ground weft yarns interwoven with the plurality of ground warp yarns. The ground component includes a second side and a first side opposed to the second side along a vertical direction, as well as a pile component extending away from the ground component along the vertical direction. The pile component includes a plurality of plied yarns, where each of the plied yarns includes 1) a first yarn that has a first yarn count, and 2) a second yarn that has a second yarn count that is greater than the first yarn count. The second yarn includes regenerated cellulose fibers.

Abstract: A method of enhanced oil recovery may comprise placing into a subterranean formation a production enhancement fluid comprising a short chain hydrocarbon phase and a silane based wettability modifier, wherein the short chain hydrocarbon phase comprises hydrocarbons having 5 or less carbon atoms; allowing the production enhancement fluid to remain in the subterranean formation for a shut-in period; and producing hydrocarbons from the subterranean formation.

Abstract: A system comprises a drive system comprising a single motor, a transmission configured to transmit power from the single motor to a first ball screw via a first clutch, and a second clutch configured to transmit power from the first ball screw to a second ball screw. The system also comprises a brake configured to apply a braking force to at least a portion of the drive system. The system further comprises a control module configured to control operation of one or more of the single motor, the first clutch, the second clutch, and the brake, where the control module is configured to move a scissors arms in a horizontal direction in a first configuration and adjust a vertical height of the scissors arms in a second configuration.

Abstract: This disclosure describes an economical and scalable method and process to synthesize the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts therefor. Uses of said intermediates for synthesis of compounds which may be intermediates to the synthesis of 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid are also described herein.

Abstract: Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, wherein, ring A, ring B, R1 to R4, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.

Abstract: A system includes a focus optic configured to converge an electromagnetic radiation (EMR) beam to a focal region located along an optical axis. The system also includes a detector configured to detect a signal radiation emanating from a predetermined location along the optical axis. The system additionally includes a controller configured to adjust a parameter of the EMR beam based in part on the signal radiation detected by the detector. The system also includes a window located a predetermined depth away from the focal region, between the focal region and the focus optic along the optical axis, wherein the window is configured to make contact with a surface of a tissue.

Abstract: The invention relates to substituted nucleoside analogues of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.

Abstract: The present invention relates to a thermal ink jet printer capable of performing continuously by maintaining consistent print quality and optimum cartridge life. More particularly, the present invention relates to a print head assembly of a thermal ink jet printer comprising of a cooling system for ink inside the cartridge, an airtight chamber to prevent heat losses into atmosphere and prevents condensation of air from atmosphere.

Abstract: A terry woven fabric includes hygro yarns structures. The hygro yarns are formed with soluble fibers, which are later removed, to define yarn structures with hollow cores.

Abstract: The invention provides for a compound having the structure of Formula (I) to Formula (VI), including Compounds 1 to 6, their pharmaceutically acceptable salts, and compositions comprising thereof. This invention further includes methods of their use for the treatment of diseases or disorders associated with the modulation of calcium sensing receptors (CaSRs), including secondary hyperparathyroidism associated with chronic kidney disease in a subject in need thereof. This disclosure further relates to a process for the preparation of said pharmaceutical compositions.

Abstract: A method may include: introducing a silane based aqueous soluble resin into a wellbore, wherein the silane based aqueous soluble resin comprises a glycidyl alkoxy silane containing resin and an amino alkoxy silane hardener. The silane based aqueous soluble resin may include 3-glycidoxypropyl trimethoxy silane and n-(3-(trimethoxysilyl)propyl)ethylenediamine.

Abstract: A process for manufacturing substituted chroman compounds in an economically scalable manner, without the use of pyrophoric reagents. Also disclosed herein are chroman compound synthesis routes that do not include column chromatography purification steps. The disclosure also relates to the intermediates used in the synthesis. In particular, the disclosure relates to the synthesis of the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts thereof.