Patents by Inventor Rajender Reddy LELETI
Rajender Reddy LELETI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11401273Abstract: The present invention relates to an improved asymmetric synthesis of azaspiro or diazaspiro compound (hereafter referred to as the compound 5, (5A) or (5N)) or their pharmaceutically acceptable salts and derivatives; through the formation of intermediate compounds 4, (4A) or (4N) respectively. The process comprises an unusual substrate specific highly diastereoselective as well as enantio-enriched 1-substituted 2-azaspiro[3.3]heptane or 1-substituted 2-diazaspiro[3.3]heptane compounds with high diastereoselectivity by addition of a cyclobutane carboxylate anion to a Davis-Ellman's imine, followed by reduction and cyclisation resulting in the selective formation of azaspiro or diazaspiro intermediate compound 4, (4A) or (4N); which on subsequently removing the sulfinyl group provides corresponding azaspiro or diazaspiro compound 5, (5A) or (5N) respectively.Type: GrantFiled: November 19, 2019Date of Patent: August 2, 2022Assignee: PIRAMAL PHARMA LIMITEDInventors: Rajender Reddy Leleti, Yogesh Waman, Priya Kallure, Zubeda Begum, Thumban Divya, Kumara Swamy Nalivela, Saurabh Vijay, Paranjay Parikh, Sharadsrikar Kotturi, Chirag Patel, Krishna Nayak, Kasimraza Baharooni, Vinkal Zalavadiya
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Patent number: 11299455Abstract: The present invention relates to an improved process for diastereoselective synthesis of vicinal diamines (1). The process involves highly regio- and diastereoselective addition of 2-azaallyl anions (4) to N-tert-butanesulfinylimines (5) to produce vicinal diamines (1).Type: GrantFiled: July 11, 2019Date of Patent: April 12, 2022Assignee: PIRAMAL PHARMA LIMITEDInventors: Rajender Reddy Leleti, Sharadsrikar Kotturi, Kumara Swamy Nalivela, Chirag Patel, Poojabahen Raval, Vinkal Zalavadiya
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Patent number: 11279668Abstract: The present invention relates to an improved asymmetric synthesis of alpha-(diarylmethyl) alkyl amines (hereafter referred to as the compound (1)) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual substrate specific regioselective lithiation of alpha-diarylmethanes. followed by its highly diastereoselective addition to N-tert-butanesulfinylimines resulting in the selective formation of chiral alpha-(diarylmethyl) alkyl amines 4 and chiral amine 5; which on subsequently removing the sulfinyl group provides corresponding alpha-(diarylmethyl) alkyl amines (1) or relative chiral amines (1?).Type: GrantFiled: March 20, 2019Date of Patent: March 22, 2022Assignee: PIRAMAL PHARMA LIMITEDInventors: Rajender Reddy Leleti, Sharadsrikar Kotturi, Yogesh Waman, Chirag Patel, Rajesh Shenoy
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Patent number: 11279672Abstract: The present invention relates to an improved asymmetric synthesis of alpha-branched amines (hereafter referred to as the compound) and relative chiral amines (1?) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual substrate specific regioselective ortho lithiation of substituted arene compounds, followed by its highly diastereoselective addition to N-tert-butanesulfinylimines resulting in the selective formation of alpha-branched sulfinyl amine and chiral amine; which on subsequently removing the sulfinyl group provides corresponding alpha-branched amines or relative chiral amines (1?).Type: GrantFiled: April 17, 2019Date of Patent: March 22, 2022Assignee: PIRAMAL PHARMA LIMITEDInventors: Rajender Reddy Leleti, Sharadsrikar Kotturi, Yogesh Waman, Chirag Patel, Aditya Patwa, Rajesh Shenoy
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Publication number: 20220073454Abstract: The present invention relates to an improved process for diastereoselective synthesis of vicinal diamines (1). The process involves highly regio- and diastereoselective addition of 2-azaallyl anions (4) to N-tert-butanesulfinylimines (5) to produce vicinal diamines (1).Type: ApplicationFiled: July 11, 2019Publication date: March 10, 2022Applicant: PIRAMAL PHARMA LIMITEDInventors: Rajender Reddy LELETI, Sharadsrikar KOTTURI, Kumara Swamy NALIVELA, Chirag PATEL, Poojabahen RAVAL, Vinkal ZALAVADIYA
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Publication number: 20220041609Abstract: The present invention relates to an improved asymmetric synthesis of azaspiro or diazaspiro compound (hereafter referred to as the compound 5, (5A) or (5N)) or their pharmaceutically acceptable salts and derivatives; through the formation of intermediate compounds 4, (4A) or (4N) respectively. The process comprises an unusual substrate specific highly diastereoselective as well as enantio-enriched 1-substituted 2-azaspiro[3.3]heptane or 1-substituted 2-diazaspiro[3.3]heptane compounds with high diastereoselectivity by addition of a cyclobutane carboxylate anion to a Davis-Ellman's imine, followed by reduction and cyclisation resulting in the selective formation of azaspiro or diazaspiro intermediate compound 4, (4A) or (4N); which on subsequently removing the sulfinyl group provides corresponding azaspiro or diazaspiro compound 5, (5A) or (5N) respectively.Type: ApplicationFiled: November 19, 2019Publication date: February 10, 2022Applicant: PIRAMAL PHARMA LIMITEDInventors: Rajender Reddy LELETI, Yogesh WAMAN, Priya KALLURE, Zubeda BEGUM, Thumban DIVYA, Kumara Swamy NALIVELA, Saurabh VIJAY, Paranjay PARIKH, Sharadsrikar KOTTURI, Chirag PATEL, Krishna NAYAK, Kasimraza BAHAROONI, Vinkal ZALAVADIYA
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Publication number: 20210114977Abstract: The present invention relates to an improved asymmetric synthesis of alpha-branched amines (hereafter referred to as the compound) and relative chiral amines (1?) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual substrate specific regioselective ortho lithiation of substituted arene compounds, followed by its highly diastereoselective addition to N-tert-butanesulfinylimines resulting in the selective formation of alpha-branched sulfinyl amine and chiral amine; which on subsequently removing the sulfinyl group provides corresponding alpha-branched amines or relative chiral amines (1?).Type: ApplicationFiled: April 17, 2019Publication date: April 22, 2021Applicant: PIRAMAL ENTERPRISES LIMITEDInventors: Rajender Reddy LELETI, Sharadsrikar KOTTURI, Yogesh WAMAN, Chirag PATEL, Aditya PATWA, Rajesh SHENOY
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Publication number: 20210061752Abstract: The present invention relates to an improved asymmetric synthesis of alpha-(diarylmethyl) alkyl amines (hereafter referred to as the compound (1)) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual substrate specific regioselective lithiation of alpha-diarylmethanes, followed by its highly diastereoselective addition to N-tert-butanesulfinylimines resulting in the selective formation of chiral alpha-(diarylmethyl) alkyl amines 4 and chiral amine 5; which on subsequently removing the sulfinyl group provides corresponding alpha-(diarylmethyl) alkyl amines (1) or relative chiral amines (1?).Type: ApplicationFiled: March 20, 2019Publication date: March 4, 2021Applicant: PIRAMAL ENTERPRISES LIMITEDInventors: Rajender Reddy LELETI, Sharadsrikar KOTTURI, Yogesh WAMAN, Chirag PATEL, Rajesh SHENOY
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Patent number: 9181235Abstract: The present invention relates to compositions and methods for modulating the Wnt signaling pathway, using compounds having Formula (1) and (3): wherein A, B, Y and Z all represent rings, and R1, R2, R3 are as defined herein.Type: GrantFiled: June 28, 2011Date of Patent: November 10, 2015Assignee: NOVARTIS AGInventors: Dai Cheng, Guobao Zhang, Dong Han, Wenqi Gao, Shifeng Pan, Lichun Shen, Rajender Reddy Leleti
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Patent number: 8748435Abstract: The present invention relates to pyrazolo pyrimidine derivatives, to methods of preparing these, to combinations and pharmaceutical composition comprising these, and to their use in the treatment of diseases and disorders which may for example involve autoimmune diseases, angiogenesis, pain, and/or inflammatory diseases.Type: GrantFiled: March 26, 2012Date of Patent: June 10, 2014Assignee: Novartis AGInventors: Wolfgang Miltz, Berndt Oberhauser, Andrea Vaupel, Juraj Velcicky, Klaus Weigand, Rajender Reddy Leleti, Yugang Liu, Zhengming Du
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Publication number: 20130079328Abstract: The present invention relates to compositions and methods for modulating the Wnt signaling pathway, using compounds having Formula (1) and (3): wherein A, B, Y and Z all represent rings, and R1, R2, R3 are as defined herein.Type: ApplicationFiled: June 28, 2011Publication date: March 28, 2013Inventors: Dai Cheng, Guobao Zhang, Dong Han, Wenqi Gao, Shifeng Pan, Lichun Shen, Rajender Reddy Leleti
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Publication number: 20120302756Abstract: The present invention provides a highly efficient, versatile one-step process for asymmetric synthesis of either diastereomer of 2-substituted pyrrolidines from a single starting material with excellent yields and high diastereoselectivety. Also provided is a method for the asymmetric synthesis of both diastereomers of 2-substituted piperidines with good yields and excellent diastereoselectivety. Diasteroselectivity is controlled effectively by choice of reducing agent.Type: ApplicationFiled: February 17, 2011Publication date: November 29, 2012Inventors: Rajender Reddy Leleti, Yugang Liu, Mahavir Prashad
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Publication number: 20120252778Abstract: The present invention relates to pyrazolo pyrimidine derivatives, to methods of preparing these, to combinations and pharmaceutical composition comprising these, and to their use in the treatment of diseases and disorders which may for example involve autoimmune diseases, angiogenesis, pain, and/or inflammatory diseases.Type: ApplicationFiled: March 26, 2012Publication date: October 4, 2012Applicant: NOVARTIS AGInventors: Wolfgang MILTZ, Berndt OBERHAUSER, Andrea VAUPEL, Juraj VELCICKY, Klaus WEIGAND, Rajender Reddy LELETI, Yugang LIU, Zhengming DU