Patents by Inventor Rajendra Makkar

Rajendra Makkar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230157658
    Abstract: Calcific and noncalcific aortic tissue components can be quantified. Pre-intervention planning computed tomography angiography imaging data is received. A region of interest is defined between the lower coronary ostium and the virtual basal ring. Cross-sectional images of the region of interest are rendered and calcific and noncalcific tissue components are identified based on Hounsfield unit thresholds. The volumes of the identified calcific and noncalcific tissue components are calculated and used to determine a total tissue volume (e.g., fibrocalcific volume) for the valve, as well as component percentages of the total tissue volume for the calcific and noncalcific components. These volumes and/or component percentages can be leveraged to predict severe AS, identify prognosis of post-TAVI outcomes, or otherwise facilitate planning of medical intervention.
    Type: Application
    Filed: November 23, 2022
    Publication date: May 25, 2023
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Damini Dey, Sebastien Cadet, Piotr Slomka, Rajendra Makkar
  • Patent number: 10869681
    Abstract: The present invention provides devices and methods for percutaneously retrieving an embolized or malpositioned heart valve or foreign bodies from a patient's body. Several of these devices may include a catheter system with expandable and retractable baskets attached to a catheter and guidewire system. The guidewire may be inserted through the lumen of the embolized or malpositioned heart valve, capturing the valve in the baskets, and deploying a mechanism to crush the valve within the baskets. Then the crushed baskets and valve may be retrieved either from the body or to a safer location such as but not limited to the descending aorta. This system is advantageous because it does not require open surgery to retrieve the valve or embolized material.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: December 22, 2020
    Assignee: Cedars-Sinai Medical Center
    Inventors: Hasanian Al-Jilaihawi, Rajendra Makkar
  • Patent number: 10543078
    Abstract: The present invention provides modular transcatheter valve replacement devices and methods of using the same to treat valvular heart diseases. Disclosed is a bottom module that contains a heart valve replacement, and a top module connected to the bottom module. The top module may be bio-absorbable, or may contain one or more severable joints that allow the top module to be removed after implantation. The removable or absorbable top portion serves to add additional length the structure to add in orientation during implantation, but is removed or absorbed to minimize the metal and other foreign material in a patient's body that could cause thrombosis or other reactions.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: January 28, 2020
    Assignee: Cedars-Sinai Medical Center
    Inventors: Hasanian Al-Jilaihawi, Rajendra Makkar
  • Patent number: 10226333
    Abstract: Described herein is a mitral valve and systems and methods for implanting the same. The mitral valve device is designed to easily orient to and conform to the mitral orifice natural morphology. This mitral valve system may be implanted using a system of 2 guide wires that facilitate orientation of the flat portion of the stent properly with the flat portion of the mitral valve that is adjacent to the aortic valve. Additionally, the disclosed valve may have multiple mounds distributed across the outer surface of the valve/stent complex so as to prevent or reduce paravalvular leak after implantation.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: March 12, 2019
    Assignee: Cedars-Sinai Medical Center
    Inventors: Hasanian Al-Jilaihawi, Rajendra Makkar
  • Publication number: 20160235422
    Abstract: The present invention provides devices and methods for percutaneously retrieving an embolized or malpositioned heart valve or foreign bodies from a patient's body. Several of these devices may include a catheter system with expandable and retractable baskets attached to a catheter and guidewire system. The guidewire may be inserted through the lumen of the embolized or malpositioned heart valve, capturing the valve in the baskets, and deploying a mechanism to crush the valve within the baskets. Then the crushed baskets and valve may be retrieved either from the body or to a safer location such as but not limited to the descending aorta. This system is advantageous because it does not require open surgery to retrieve the valve or embolized material.
    Type: Application
    Filed: October 16, 2014
    Publication date: August 18, 2016
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Hasanian Al-Jilaihawi, Rajendra Makkar
  • Publication number: 20160228013
    Abstract: Described herein is a guide wire that includes one, two or multiple pressure transducers for use in TAVI. The guide wire may include an aortic pressure sensor spaced from a left ventricular pressure sensor with sufficient length to allow the aortic pressure sensor to be located in the aorta while the ventricular pressure sensor is simultaneously located in the left ventricle. The pressure readings between the left ventricle and aorta may be subtracted to determine an improved indication of the prognosis of a patient with intermediate post-TAVR aortic regurgitation after assessment with transesophageal echocardiography.
    Type: Application
    Filed: October 7, 2014
    Publication date: August 11, 2016
    Applicant: Cedars-Sinai Medical Center
    Inventors: Hasanian Al-Jilaihawi, Rajendra Makkar
  • Publication number: 20160228241
    Abstract: The present invention provides modular transcatheter valve replacement devices and methods of using the same to treat valvular heart diseases. Disclosed is a bottom module that contains a heart valve replacement, and a top module connected to the bottom module. The top module may be bio-absorbable, or may contain one or more severable joints that allow the top module to be removed after implantation. The removable or absorbable top portion serves to add additional length the structure to add in orientation during implantation, but is removed or absorbed to minimize the metal and other foreign material in a patient's body that could cause thrombosis or other reactions.
    Type: Application
    Filed: October 16, 2014
    Publication date: August 11, 2016
    Applicant: Cedars-Sinai Medical Center
    Inventors: Hasanian Al-Jilaihawi, Rajendra Makkar
  • Publication number: 20160206424
    Abstract: Described herein is a mitral valve and systems and methods for implanting the same. The mitral valve device is designed to easily orient to and conform to the mitral orifice natural morphology. This mitral valve system may be implanted using a system of 2 guide wires that facilitate orientation of the flat portion of the stent properly with the flat portion of the mitral valve that is adjacent to the aortic valve. Additionally, the disclosed valve may have multiple mounds distributed across the outer surface of the valve/stent complex so as to prevent or reduce paravalvular leak after implantation.
    Type: Application
    Filed: October 14, 2014
    Publication date: July 21, 2016
    Applicant: Cedars-Sinai Medical Center
    Inventors: Hasanian Al-Jilaihawi, Rajendra Makkar