Abstract: Compositions for enhancing TFEB-mediated intracellular clearance are herein. Particularly, a complex comprising synergistic combination of polyamine and histidine-containing dipeptide present in a specific weight ratio along with pharmaceutically acceptable excipients is provided herein. More particularly, the composition comprises a synergistic blend of N-(3-Aminopropyl)-1,4-butanediamine and N-?-Acetyl-N-?-alanyl-L-histidine and salts thereof along with pharmaceutically acceptable excipients. Furthermore, the present synergistic composition is useful for improving or inducing autophagy, lysosomal biogenesis, mitophagy and lipophagy.

Abstract: The invention disclosed herein relates to synergistic bioactive compositions for inhibiting vascular calcification. Particularly, the present invention relates to exogenous blend of magnesium 2-acetylamino ethane sulfonic acid and 2-methyl-4-aminomethyl-5-hydroxymethyl-3-pyridinol and salts thereof which are present in the weight ratio of 1:0.002 to 1:1.8 along with pharmaceutically acceptable excipients. More particularly, the synergistic composition is useful for treating cardiovascular diseases and renal vascular diseases.