Patents by Inventor Rajendra Uprety

Rajendra Uprety has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted alkylphenols as HCN1 antagonists
    Patent number: 11684590
    Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: June 27, 2023
    Assignee: Cornell University
    Inventors: Gareth R. Tibbs, Peter A. Goldstein, Anthony A. Sauve, Rajendra Uprety, James David Warren, Jr., Rebecca L. Joyce, Dipti N. Barman
  • G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment
    Patent number: 11613547
    Abstract: In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the pain of a patient. These compounds may be used in pain relief and show an improved pharmaceutical profile relative to other commonly used opiates and opioid derivatives.
    Type: Grant
    Filed: July 8, 2020
    Date of Patent: March 28, 2023
    Assignees: University of Health Sciences & Pharmacy in St. Louis, University of Southern California, The University of North Carolina at Chapel Hill, Memorial Sloan Kettering Cancer Center, University of Florida Research Foundation, Incorporated
    Inventors: Susruta Majumdar, Vsevolod Katritch, Bryan Roth, Jay McLaughlin, Saheem Zaidi, Gavril W. Pasternak, Rajendra Uprety
  • SUBSTITUTED ALKYLPHENOLS AS HCN1 ANTAGONISTS
    Publication number: 20210267909
    Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.
    Type: Application
    Filed: June 27, 2019
    Publication date: September 2, 2021
    Applicant: Cornell University
    Inventors: Gareth R. Tibbs, Peter A. Goldstein, Anthony A. Sauve, Rajendra Uprety, James David Warren, Rebecca L. Joyce, Dipti N. Barman
  • G-PROTEIN BIASED OPIOID RECEPTOR AGONIST/ANALGESICS WITH REDUCED ARRESTIN RECRUITMENT
    Publication number: 20210061814
    Abstract: In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the pain of a patient. These compounds may be used in pain relief and show an improved pharmaceutical profile relative to other commonly used opiates and opioid derivatives.
    Type: Application
    Filed: July 8, 2020
    Publication date: March 4, 2021
    Applicants: St. Louis College of Pharmacy, University of Southern California, The University of North Carolina at Chapel Hill, Memorial Sloan Kettering Cancer Center, University of Florida Research Foundation, Incorporated
    Inventors: Susruta MAJUMDAR, Vsevolod KATRITCH, Bryan ROTH, JAY MCLAUGHLIN, Saheem ZAIDI, Gavril W. PASTERNAK, Rajendra UPRETY
  • Methods for Incorporating Unnatural Amino Acids in Eukaryotic Cells
    Publication number: 20130183761
    Abstract: The invention relates to a nucleic acid comprising a nucleotide sequence encoding a tRNA orthogonal to a eukaryotic cell, said nucleotide sequence operably linked to a promoter capable of directing transcription by eukaryotic RNA polymerase III. The invention also relates to methods for incorporating unnatural amino acids in eukaryotic cells using same.
    Type: Application
    Filed: September 23, 2011
    Publication date: July 18, 2013
    Applicants: North Carolina State University, Medical Research Council
    Inventors: Jason Chin, Alexandre Deiters, Rajendra Uprety, Susan M. Hancock, Sebastian Greiss