Patents by Inventor Rajesh A. Khanna
Rajesh A. Khanna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200000585Abstract: A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve. The method can also include crimping the implantable prosthetic valve with the protective material on the implantable prosthetic valve, and removing the protective material from between the frame and the leaflet structure of the implantable prosthetic valve.Type: ApplicationFiled: September 13, 2019Publication date: January 2, 2020Inventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
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Patent number: 10492905Abstract: A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve. The method can also include crimping the implantable prosthetic valve with the protective material on the implantable prosthetic valve, and removing the protective material from between the frame and the leaflet structure of the implantable prosthetic valve.Type: GrantFiled: May 21, 2018Date of Patent: December 3, 2019Assignee: Edwards Lifesciences CorporationInventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
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Patent number: 10441586Abstract: The present invention provides compounds that can modulate the amount of Nav 1.7 protein, a key protein in pain signaling, that is present in the cellular surface and methods for using such compounds. In particular, compounds of the invention modulate the amount of Nav 1.7 protein on the cellular surface by modulating SUMOylation of CRMP2. Thus, compounds of the invention can be used to treat various clinical conditions associated with the presence and/or activation of Nav 1.7 protein on the cellular surface and/or SUMOylation of CRMP2.Type: GrantFiled: October 7, 2016Date of Patent: October 15, 2019Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONAInventors: May Khanna, Rajesh Khanna, Vijay Gokhale, Reena Chawla
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Patent number: 10426611Abstract: A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve. The method can also include crimping the implantable prosthetic valve with the protective material on the implantable prosthetic valve, and removing the protective material from between the frame and the leaflet structure of the implantable prosthetic valve.Type: GrantFiled: November 28, 2018Date of Patent: October 1, 2019Assignee: Edwards Lifesciences CorporationInventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
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Patent number: 10413407Abstract: A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve. The method can also include crimping the implantable prosthetic valve with the protective material on the implantable prosthetic valve, and removing the protective material from between the frame and the leaflet structure of the implantable prosthetic valve.Type: GrantFiled: November 28, 2018Date of Patent: September 17, 2019Assignee: Edwards Lifesciences CorporationInventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
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Patent number: 10299923Abstract: A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve. The method can also include crimping the implantable prosthetic valve with the protective material on the implantable prosthetic valve, and removing the protective material from between the frame and the leaflet structure of the implantable prosthetic valve.Type: GrantFiled: November 28, 2018Date of Patent: May 28, 2019Assignee: Edwards Lifesciences CorporationInventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
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Patent number: 10292817Abstract: A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve. The method can also include crimping the implantable prosthetic valve with the protective material on the implantable prosthetic valve, and removing the protective material from between the frame and the leaflet structure of the implantable prosthetic valve.Type: GrantFiled: November 28, 2018Date of Patent: May 21, 2019Assignee: Edwards Lifesciences CorporationInventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
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Patent number: 10289782Abstract: The present disclosure relates to a computer-implemented method for electronic design automation. Embodiments may include providing, using at least one processor, an electronic circuit design at a graphical user interface. Embodiments may further include associating one or more metrics with the electronic circuit design, wherein the one or more metrics include at least one of process metrics, design metrics, issues, library metrics, and custom metrics. Embodiments may further include allowing a user to specify one or more rules that define a key performance indicator for at least a portion of the electronic circuit design, wherein the key performance indicator is based upon, at least in part, the one or more metrics. After a design process associated with the electronic circuit design has been initiated, embodiments may include displaying the key performance indicator at the graphical user interface.Type: GrantFiled: June 1, 2016Date of Patent: May 14, 2019Assignee: Cadence Design Systems, Inc.Inventors: Rajesh Khanna, Matthew Timothy Bromley
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Patent number: 10287334Abstract: Disclosed herein are isolated polypeptides capable of preventing collapsin response mediator protein 2 (CRMP2)-small ubiquitin-like modifier (SUMO)ylation mediated trafficking of voltage gated sodium channel 1.7 (Nav1.7) function. In some examples, the disclosed peptides comprise three to twenty amino acids and include the amino acid sequence KMD. Also disclosed are methods of decreasing nociception including administering an effective amount of one or more disclosed peptides to a subject in need thereof, such as a subject experiencing chronic pain.Type: GrantFiled: March 6, 2015Date of Patent: May 14, 2019Assignee: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONAInventors: Rajesh Khanna, May Khanna, Todd W. Vanderah, Erik T. Dustrude
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Patent number: 10289783Abstract: The present disclosure relates to a computer-implemented method for use in an electronic circuit design. Embodiments may include providing, using at least one processor, an electronic circuit design and generating a configuration associated with a portion of the electronic circuit design. Embodiments may further include associating a label with the configuration at a graphical user interface and applying the configuration to at least one of a design object, a sub-design, or the electronic circuit design. Embodiments may also include displaying the configuration and electronic design data associated with the configuration.Type: GrantFiled: June 1, 2016Date of Patent: May 14, 2019Assignee: Cadence Design Systems, Inc.Inventors: Rajesh Khanna, Matthew Timothy Bromley
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Publication number: 20190099269Abstract: A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve. The method can also include crimping the implantable prosthetic valve with the protective material on the implantable prosthetic valve, and removing the protective material from between the frame and the leaflet structure of the implantable prosthetic valve.Type: ApplicationFiled: November 28, 2018Publication date: April 4, 2019Applicant: Edwards Lifesciences CorporationInventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
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Publication number: 20190099268Abstract: A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve. The method can also include crimping the implantable prosthetic valve with the protective material on the implantable prosthetic valve, and removing the protective material from between the frame and the leaflet structure of the implantable prosthetic valve.Type: ApplicationFiled: November 28, 2018Publication date: April 4, 2019Applicant: Edwards Lifesciences CorporationInventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
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Publication number: 20190091018Abstract: A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve. The method can also include crimping the implantable prosthetic valve with the protective material on the implantable prosthetic valve, and removing the protective material from between the frame and the leaflet structure of the implantable prosthetic valve.Type: ApplicationFiled: November 28, 2018Publication date: March 28, 2019Applicant: Edwards Lifesciences CorporationInventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
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Patent number: 10178080Abstract: The present disclosure relates to a computer-implemented method for electronic design automation. Embodiments may include providing an initial electronic circuit design and receiving an initial parts list configured to include at least one of logical parts and physical parts associated with the initial electronic circuit design. Embodiments may further include providing authorization to at least one user to edit the initial parts list via a graphical user interface, wherein the at least one user is a subset of all possible users. Embodiments may also include receiving an update to the initial parts list from the at least one user via the graphical user interface and generating an updated parts list based upon, at least in part, the update. Embodiments may further include allowing access to the updated parts list to one or more additional users.Type: GrantFiled: June 1, 2016Date of Patent: January 8, 2019Assignee: Cadence Design Systems, Inc.Inventors: Rajesh Khanna, Matthew Timothy Bromley
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Publication number: 20180289700Abstract: The present invention provides compounds that can modulate the amount of Nav 1.7 protein, a key protein in pain signaling, that is present in the cellular surface and methods for using such compounds. In particular, compounds of the invention modulate the amount of Nav 1.7 protein on the cellular surface by modulating SUMOylation of CRMP2. Thus, compounds of the invention can be used to treat various clinical conditions associated with the presence and/or activation of Nav 1.7 protein on the cellular surface and/or SUMOylation of CRMP2.Type: ApplicationFiled: October 7, 2016Publication date: October 11, 2018Applicant: Arizona Board of Regents on Behalf of the University of ArzonaInventors: May Khanna, Rajesh Khanna, Vijay Gokhale, Reena Chawla
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Publication number: 20180263769Abstract: A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve. The method can also include crimping the implantable prosthetic valve with the protective material on the implantable prosthetic valve, and removing the protective material from between the frame and the leaflet structure of the implantable prosthetic valve.Type: ApplicationFiled: May 21, 2018Publication date: September 20, 2018Inventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
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Publication number: 20180235967Abstract: The present invention relates to a tablet comprising Afatinib or a pharmaceutically acceptable salt thereof, wherein the tablet is obtained by direct compression. The present invention further relates to a process for manufacturing a tablet of the invention as well as the use of the tablet of the invention.Type: ApplicationFiled: August 19, 2016Publication date: August 23, 2018Applicant: FRESENIUS KABI ONCOLOGY LTD.Inventors: Rajesh KHANNA, Neeraj KUMAR, Vijay Kumar SHARMA, Ankit GAUR, Dhiraj KHATTAR
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Patent number: 10043222Abstract: A system and method are provided for adaptively optimized recomposition of a parts list for fabrication of an electronic circuit product. A parts list acquisition portion forms a parts list containing a plurality of constituent parts entries read from one or more predetermined sources. The parts entries are respectively identified in the parts list by different corresponding part identifiers. An optimization unit coupled to the parts list acquisition unit comparatively determines mutual matching between different parts entries based on at least one optimization parameter. The optimization unit intermediately recomposes the parts list by incorporating one or more suggested parts substitutions to adaptively consolidate mutually matched pairs of parts entries.Type: GrantFiled: September 22, 2014Date of Patent: August 7, 2018Assignee: Cadence Design Systems, Inc.Inventors: Matt Bromley, Rajesh Khanna
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Patent number: 9974652Abstract: A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve. The method can also include crimping the implantable prosthetic valve with the protective material on the implantable prosthetic valve, and removing the protective material from between the frame and the leaflet structure of the implantable prosthetic valve.Type: GrantFiled: May 19, 2017Date of Patent: May 22, 2018Assignee: Edwards Lifesciences CorporationInventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
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Patent number: 9968608Abstract: A pharmaceutical composition of Pemetrexed represented by formula (I), which is a liquid ready to use solution formulation or a lyophilized pharmaceutical composition for parenteral administration comprising a pharmaceutically acceptable organic amine, an inert gas and optionally containing at least one or more pharmaceutically acceptable excipients. Also provided are processes for preparation of the ready to use solution formulation or lyophilized pharmaceutical composition of the present invention.Type: GrantFiled: July 1, 2016Date of Patent: May 15, 2018Assignee: Fresenius Kabi Oncology LimitedInventors: Dhiraj Khattar, Rajesh Khanna, Mukti Yadav, Krishanu Burman