Abstract: Compositions are described in which certain thyroid hormone receptor-binding compounds are formulated together with either an enteric coating, an antioxidant, or both an enteric coating and an antioxidant. Such formulation acts to prevent the formation of undesired reaction products in vivo.

Abstract: A process for the formation of Stavudine Polymorphic Form I from a mixture comprising Polymorphic Form I and at least one of Polymorphic Forms II and III is disclosed using the technique of Solution-Enhanced Dispersion by Supercritical Fluids (SEDS). A solution of the mixture in isopropyl alcohol/water is introduced into a particle formation vessel with a supercritical fluid under controlled temperature and pressure whereby the supercritical fluid substantially simultaneously disperses and extracts the solvent from the solution forming discrete particles of Stavudine Polymorphic Form I. A preferred supercritical fluid is carbon dioxide.

Abstract: The present invention concerns a novel process using controlled cooling for obtaining d.sub.4 T polymorphic Form I from a mixture containing one or more of polymorphic Forms I, II and III. Compound d.sub.4 T has been approved for use in the treatment of AIDS.