Abstract: A medical knowledge database including medical knowledge information, medical diagnoses, and medical treatments, is used for machine learning for collaborative medical data metrics. Medical data is collected from a plurality of clinicians serving a first plurality of patients and assembling a medical knowledge database that includes medical knowledge information, medical diagnoses, and medical treatments. The medical knowledge database is a function of demographics and comprises a medical probabilistic rules graph. The medical knowledge database is augmented based on further medical data collected from a second plurality of clinicians. The further medical data is based on individual patient treatment outcomes collected by the second plurality of clinicians. Medical data from a further patient is applied to the medical probabilistic rules graph. A medical diagnosis is provided, based on the medical data applied from a further patient to the rules graph.

Abstract: A medical knowledge database including medical knowledge information, medical diagnoses, and medical treatments, is used for machine learning for collaborative medical data metrics. Medical data is collected from a plurality of clinicians serving a first plurality of patients and assembling a medical knowledge database that includes medical knowledge information, medical diagnoses, and medical treatments. The medical knowledge database is a function of demographics and comprises a medical probabilistic rules graph. The medical knowledge database is augmented based on further medical data collected from a second plurality of clinicians. The further medical data is based on individual patient treatment outcomes collected by the second plurality of clinicians. Medical data from a further patient is applied to the medical probabilistic rules graph. A medical diagnosis is provided, based on the medical data applied from a further patient to the rules graph.

Abstract: Biological information and medical knowledge information are used for self-learning clinical intelligence. Medical knowledge information is assembled. Medical rules are generated based on the medical knowledge. The medical rules can be generated probabilistically. A plurality of risk models can be learned. The plurality of risk models are associated with a given disease based on patient attributes. A medical probabilistic rule graph is built based on the medical rules and the plurality of risk models. The building of the medical probabilistic rule graph is based on ordering the medical rules. Attributes from an individual patient are applied to the medical probabilistic rule graph. A diagnosis for the individual is generated from the attributes applied to the medical probabilistic rule graph. A treatment for the individual can be generated from the attributes applied to the medical probabilistic rule graph.

Abstract: The methods of the invention exploit the capabilities of manganese-enhanced MRI (MEMRI), which provides viability-specific biological contrast agent through the intracellular accumulation of Mn2+. A typical contrast agent utilizes non-chelated Mn2+ in combination with Ca2+, e.g. as calcium gluconate. Active intracellular accumulation of Mn2+ generates high signal from the viable cells in normal tissue, or normal regions of heterogeneous tissue; no signal from the non-viable cells; and intermediate signal from viable but injured cells. The intermediate signal defines a “gray zone” of potentially salvageable cells.