Abstract: The present disclosure provides improved systems and methods utilizing colloidal/ultrafine superdisintegrant-based composite particles for dispersion and/or dissolution of active pharmaceutical agents. In general, the present disclosure utilizes a surfactant-free or near surfactant-free formulation by incorporating a wet milled SDI as a dispersant in the formulation. As such, the present disclosure provides for the preparation of surfactant-free or substantially surfactant-free formulations (e.g., nano-composite micro-particle formulations) by incorporating a wet-milled superdisintegrant (SDI) as the dispersant in the formulations. The advantageous SDI particles (e.g., colloidal/ultrafine SDI particles) of the present disclosure can be used to break-up the aggregates (e.g., nanoparticle aggregates) of the active agents (e.g. poorly water-soluble drugs) in the formulations (e.g.

Abstract: A composite particle including a core with at least one carrier material; a fluidizing material layer on the surface of the core; and an outer layer comprising nanoparticles of an ingestible material distributed in at least one matrix-forming material. A process of making the composite particles includes the steps of dry coating carrier particles with a fluidizing material; preparing a suspension of nanoparticles of an ingestible material distributed in a matrix-forming material; and fluid bed coating the carrier particles with the suspension. The process and products provide quick dissolving composite particles which can be used for delivery of poorly water soluble ingestible materials in suitable dosage forms. The process of the invention reduces or prevents particle agglomeration during fabrication of the composite particles to enable delivery and quick redispersion of nanoparticles of the ingestible material from a dosage form.

Abstract: Migration of a virtual machine and associated files to a destination host may be performed. A source host may initiate establishment of a temporary network file share at a destination location of the destination host to provide the source host and the destination host with access to the file share. While the virtual machine is running at the source host, a storage migration and a live migration may be initiated. Using the network file share, the source host may copy the associated files to the destination location. A runtime state of the virtual machine may be copied to the destination host. In a final phase of the migration, the virtual machine at the source host may be stopped, the storage migration may be completed, the copying of the runtime state may be completed, and the virtual machine may be started at the destination host.

Abstract: The present disclosure provides improved systems and methods utilizing colloidal/ultrafine superdisintegrant-based composite particles for dispersion and/or dissolution of active pharmaceutical agents. In general, the present disclosure utilizes a surfactant-free or near surfactant-free formulation by incorporating a wet milled SDI as a dispersant in the formulation. As such, the present disclosure provides for the preparation of surfactant-free or substantially surfactant-free formulations (e.g., nano-composite micro-particle formulations) by incorporating a wet-milled superdisintegrant (SDI) as the dispersant in the formulations. The advantageous SDI particles (e.g., colloidal/ultrafine SDI particles) of the present disclosure can be used to break-up the aggregates (e.g., nanoparticle aggregates) of the active agents (e.g. poorly water-soluble drugs) in the formulations (e.g.

Abstract: The present disclosure provides improved systems and methods utilizing colloidal/ultrafine superdisintegrant-based composite particles for dispersion and/or dissolution of active pharmaceutical agents. In general, the present disclosure utilizes a surfactant-free or near surfactant-free formulation by incorporating a wet milled SDI as a dispersant in the formulation. As such, the present disclosure provides for the preparation of surfactant-free or substantially surfactant-free formulations (e.g., nano-composite micro-particle formulations) by incorporating a wet-milled superdisintegrant (SDI) as the dispersant in the formulations. The advantageous SDI particles (e.g., colloidal/ultrafine SDI particles) of the present disclosure can be used to break-up the aggregates (e.g., nanoparticle aggregates) of the active agents (e.g. poorly water-soluble drugs) in the formulations (e.g.

Abstract: A composite particle including a core with at least one carrier material; a fluidizing material layer on the surface of the core; and an outer layer comprising nanoparticles of an ingestible material distributed in at least one matrix-forming material. A process of making the composite particles includes the steps of dry coating carrier particles with a fluidizing material; preparing a suspension of nanoparticles of an ingestible material distributed in a matrix-forming material; and fluid bed coating the carrier particles with the suspension. The process and products provide quick dissolving composite particles which can be used for delivery of poorly water soluble ingestible materials in suitable dosage forms. The process of the invention reduces or prevents particle agglomeration during fabrication of the composite particles to enable delivery and quick redispersion of nanoparticles of the ingestible material from a dosage form.

Abstract: A health monitoring technique monitors the health and performance of applications executing in a guest partition in a virtualized environment. In an embodiment, a guest integration component interacts with an application through an application programming interface in order for the virtualization platform to monitor the health and performance of the application. In another embodiment, the guest integration component may include a monitoring agent that accesses an event log and/or a performance monitor log to access the health and performance of the application. The health and performance of the application may then be analyzed by the virtualization platform to determine an appropriate remedial action.

Abstract: A health monitoring technique monitors the health and performance of applications executing in a guest partition in a virtualized environment. In an embodiment, a guest integration component interacts with an application through an application programming interface in order for the virtualization platform to monitor the health and performance of the application. In another embodiment, the guest integration component may include a monitoring agent that accesses an event log and/or a performance monitor log to access the health and performance of the application. The health and performance of the application may then be analyzed by the virtualization platform to determine an appropriate remedial action.

Abstract: A health monitoring technique monitors the health and performance of applications executing in a guest partition in a virtualized environment. In an embodiment, a guest integration component interacts with an application through an application programming interface in order for the virtualization platform to monitor the health and performance of the application. In another embodiment, the guest integration component may include a monitoring agent that accesses an event log and/or a performance monitor log to access the health and performance of the application. The health and performance of the application may then be analyzed by the virtualization platform to determine an appropriate remedial action.

Abstract: The present disclosure provides improved systems and methods utilizing colloidal/ultrafine superdisintegrant-based composite particles for dispersion and/or dissolution of active pharmaceutical agents. In general, the present disclosure utilizes a surfactant-free or near surfactant-free formulation by incorporating a wet milled SDI as a dispersant in the formulation. As such, the present disclosure provides for the preparation of surfactant-free or substantially surfactant-free formulations (e.g., nano-composite micro-particle formulations) by incorporating a wet-milled superdisintegrant (SDI) as the dispersant in the formulations. The advantageous SDI particles (e.g., colloidal/ultrafine SDI particles) of the present disclosure can be used to break-up the aggregates (e.g., nanoparticle aggregates) of the active agents (e.g. poorly water-soluble drugs) in the formulations (e.g.

Abstract: Migration of a virtual machine and associated files to a destination host may be performed. A source host may initiate establishment of a temporary network file share at a destination location of the destination host to provide the source host and the destination host with access to the file share. While the virtual machine is running at the source host, a storage migration and a live migration may be initiated. Using the network file share, the source host may copy the associated files to the destination location. A runtime state of the virtual machine may be copied to the destination host. In a final phase of the migration, the virtual machine at the source host may be stopped, the storage migration may be completed, the copying of the runtime state may be completed, and the virtual machine may be started at the destination host.

Abstract: Migration of a virtual machine and associated files to a destination host may be performed. A source host may initiate establishment of a temporary network file share at a destination location of the destination host to provide the source host and the destination host with access to the file share. While the virtual machine is running at the source host, a storage migration and a live migration may be initiated. Using the network file share, the source host may copy the associated files to the destination location. A runtime state of the virtual machine may be copied to the destination host. In a final phase of the migration, the virtual machine at the source host may be stopped, the storage migration may be completed, the copying of the runtime state may be completed, and the virtual machine may be started at the destination host.

Abstract: Migration of a virtual machine and associated files to a destination host may be performed. A source host may initiate establishment of a temporary network file share at a destination location of the destination host to provide the source host and the destination host with access to the file share. While the virtual machine is running at the source host, a storage migration and a live migration may be initiated. Using the network file share, the source host may copy the associated files to the destination location. A runtime state of the virtual machine may be copied to the destination host. In a final phase of the migration, the virtual machine at the source host may be stopped, the storage migration may be completed, the copying of the runtime state may be completed, and the virtual machine may be started at the destination host.

Abstract: A health monitoring technique monitors the health and performance of applications executing in a guest partition in a virtualized environment. In an embodiment, a guest integration component interacts with an application through an application programming interface in order for the virtualization platform to monitor the health and performance of the application. In another embodiment, the guest integration component may include a monitoring agent that accesses an event log and/or a performance monitor log to access the health and performance of the application. The health and performance of the application may then be analyzed by the virtualization platform to determine an appropriate remedial action.

Abstract: A method for the continuous production of finely ground particulates coated with a barrier, or other desirable film wherein the coated particulates exhibit a diameter of less than 10 microns. In an exemplary embodiment, large coated particulates are introduced into a fluid energy, or jet mill, along with smaller, uncoated particulates. As the particulates collide within the mill they are comminuted, and an amount of coating is transferred from the coated particulates to the uncoated ones such that they become sufficiently coated and size-reduced to a desired size. Alternatively, uncoated particulates are milled and coated during their milling. Still alternatively, uncoated particulates are milled and subsequently directed through an atomized mist of coating material wherein the size of the mist droplets are as large, or larger than the directed particulates.

Abstract: Techniques and processes that combine particulate coating processes with particulate handling steps resulting in the formation of free-flowing particulates for introduction into energetic product vessels to affect an in-situ, net-shape manufactured product. The processes involve selecting suitably sized materials, processing such materials such that they are surface-coated and/or locally “structured” particulates, and pouring, preferably “dry” pouring, these processed materials into an energetic product vessel and infusing the filled vessel with a polymerizable and surface-compatible monomer or oligomer which flows into the unoccupied volume, followed by polymerization of the monomer, which then becomes the binder giving mechanical integrity to the final, net-shape energetic composition.

Abstract: Systems and methods for achieving filtration are provided that utilize agglomerates or granules of nanoparticles. The agglomerates or granules of nanoparticles may be used as and/or incorporated into a HEPA filtration system to remove solid or liquid submicron-sized particles, e.g., MPPS, in an efficient and efficacious manner. The filtration systems and methods are provided that utilize agglomerates or granules in a size range of about 100-500 microns. The agglomerates or granules of nanoparticles exhibit a hierarchical fractal structure. In the case of agglomerates of nanoparticles, porosities of 0.9 or greater are generally employed, and for granules of nanoparticles, porosities that are smaller than 0.9 may be employed. Filter media formed from the agglomerates or granules may be formed from materials such as carbon black and fumed silica, and may be employed in baffled or non-baffled filtration apparatus.

Abstract: Systems and methods for achieving filtration are provided that utilize agglomerates or granules of nanoparticles. The agglomerates or granules of nanoparticles may be used as and/or incorporated into a HEPA filtration system to remove solid or liquid submicron-sized particles, e.g., MPPS, in an efficient and efficacious manner. The filtration systems and methods are provided that utilize agglomerates or granules in a size range of about 100-500 microns. The agglomerates or granules of nanoparticles exhibit a hierarchical fractal structure. In the case of agglomerates of nanoparticles, porosities of 0.9 or greater are generally employed, and for granules of nanoparticles, porosities that are smaller than 0.9 may be employed. Filter media formed from the agglomerates or granules may be formed from materials such as carbon black and fumed silica, and may be employed in baffled or non-baffled filtration apparatus.

Abstract: A process, method and/or system for preparing polymer-coated nanoparticles and/or other ultrafine particles utilizing a supercritical fluid, e.g., supercritical carbon dioxide (SC CO2), as an antisolvent that may be added to a solution of a polymer and an organic solvent in which insoluble nanoparticles or the like are suspended. The coating process occurs when the supercritical fluid (e.g., SC CO2) and the nanoparticle-containing suspension are combined to cause the suspended nanoparticles to precipitate as coated nanoparticles. Processing parameters for optimizing and/or enhancing the efficacy and/or efficiency of the coating process, method and/or system and for controlling the coating and/or agglomeration of coated particles are also described. The process, method and/or system has wide ranging applicability, e.g., for coating and/or encapsulation of pharmaceuticals, cosmetics, food products, chemicals, agrochemicals, pesticides, polymers, coatings, catalysts and the like.

Abstract: An anti-solvent fluid technique is provided that assists in the formation, production and manufacture of fine particles including micro-sized and nanometer-sized particles for a wide variety of bio-medical and pharmaceutical applications. This technique is particularly effective for the manufacturing of polymers/biopolymers/drugs of micron, submicron or nano size as well as particle coating/encapsulation. Co-solvents are used to dissolve the polymer or mixture of polymers to make a solution. The method facilitates rapid drying of precipitated particles with reduced size and agglomerations.