Patents by Inventor Rajesh Jagannathbhai Jha

Rajesh Jagannathbhai Jha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100184990
    Abstract: The invention describes an improved process for the manufacture of a Flecainide intermediate viz N-(pyridin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide (II). It consists of reacting 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with an acid chloride in a solvent mixture in presence of a base at ?10 to ?50° C. The resulting mixed anhydride is then condensed with 2-aminomethylpyridine at ?10 to ?40° C. and the resulting product after aqueous workup is purified by crystallization. This affords the intermediate II in vastly improved yields and quality. The intermediate II on catalytic hydrogenation affords N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide (Flecainide), isolated as its acetate.
    Type: Application
    Filed: September 9, 2005
    Publication date: July 22, 2010
    Inventors: Harmander Pal Singh Chawla, Anil Shankar Chowdhary, Piyush Bhikhubhai Limbad, Rajesh Jagannathbhai Jha, Vipul Narbheshankar Joshi