Abstract: Methods and compositions for enhancing the therapeutic activity of agents at low doses as a result of improved targeted drug delivery, namely precision delivery, are described. The methods and compositions can be used to decrease the effective administered amounts of active therapeutic agents via precision delivery to targets capable of mediating active transport across the biological barrier formed by the vasculature that lines blood vessels. Antibodies (and other targeting agent species) to precisely deliver an active ingredient (i.e., a therapeutic agent) to cells expressing, for example, a target protein on their cell membranes, are also described, as are methods of treating disease.

Abstract: A multi-processor computer system is described in which transaction processing is distributed among multiple protocol engines. The system includes a plurality of local nodes and an interconnection controller interconnected by a local point-to-point architecture. The interconnection controller comprises a plurality of protocol engines for processing transactions. Transactions are distributed among the protocol engines using destination information associated with the transactions.

Abstract: A multi-processor computer system is described in which transaction processing is distributed among multiple protocol engines. The system includes a plurality of local nodes and an interconnection controller interconnected by a local point-to-point architecture. The interconnection controller comprises a plurality of protocol engines for processing transactions. Transactions are distributed among the protocol engines using destination information associated with the transactions.

Abstract: One embodiment sets forth a technique for ensuring relaxed coherency between different caches. Two different execution units may be configured to access different caches that may store one or more cache lines corresponding to the same memory address. During time periods between memory barrier instructions relaxed coherency is maintained between the different caches. More specifically, writes to a cache line in a first cache that corresponds to a particular memory address are not necessarily propagated to a cache line in a second cache before the second cache receives a read or write request that also corresponds to the particular memory address. Therefore, the first cache and the second are not necessarily coherent during time periods of relaxed coherency. Execution of a memory barrier instruction ensures that the different caches will be coherent before a new period of relaxed coherency begins.

Abstract: A multi-processor computer system is described in which transaction processing is distributed among multiple protocol engines. The system includes a plurality of local nodes and an interconnection controller interconnected by a local point-to-point architecture. The interconnection controller comprises a plurality of protocol engines for processing transactions. Transactions are distributed among the protocol engines using destination information associated with the transactions.

Abstract: One embodiment sets forth a technique for ensuring relaxed coherency between different caches. Two different execution units may be configured to access different caches that may store one or more cache lines corresponding to the same memory address. During time periods between memory barrier instructions relaxed coherency is maintained between the different caches. More specifically, writes to a cache line in a first cache that corresponds to a particular memory address are not necessarily propagated to a cache line in a second cache before the second cache receives a read or write request that also corresponds to the particular memory address. Therefore, the first cache and the second are not necessarily coherent during time periods of relaxed coherency. Execution of a memory barrier instruction ensures that the different caches will be coherent before a new period of relaxed coherency begins.

Abstract: A multi-processor computer system is described in which transaction processing is distributed among multiple protocol engines. The system includes a plurality of local nodes and an interconnection controller interconnected by a local point-to-point architecture. The interconnection controller comprises a plurality of protocol engines for processing transactions. Transactions are distributed among the protocol engines using destination information associated with the transactions.

Abstract: A multi-processor computer system is described in which transaction processing in each cluster of processors is distributed among multiple protocol engines. Each cluster includes a plurality of local nodes and an interconnection controller interconnected by a local point-to-point architecture. The interconnection controller in each cluster comprises a plurality of protocol engines for processing transactions. Transactions are distributed among the protocol engines using destination information associated with the transactions.

Abstract: A multi-processor computer system is described in which transaction processing in each cluster of processors is distributed among multiple protocol engines. Each cluster includes a plurality of local nodes and an interconnection controller interconnected by a local point-to-point architecture. The interconnection controller in each cluster comprises a plurality of protocol engines for processing transactions. Transactions are distributed among the protocol engines using destination information associated with the transactions.

Abstract: A multi-processor computer system is described in which transaction processing in each cluster of processors is distributed among multiple protocol engines. Each cluster includes a plurality of local nodes and an interconnection controller interconnected by a local point-to-point architecture. The interconnection controller in each cluster comprises a plurality of protocol engines for processing transactions. Transactions are distributed among the protocol engines using destination information associated with the transactions.

Abstract: Methods and apparatus are provided for improving the distribution of system management signals within a computer system complex. Mechanisms are provided for transmission both within a box and between computer system boxes. Local routing tables and general routing tables allow the distribution of system management signals precisely to resources associated with particular partitions. Signals are sequenced to put resources associated with one or more boxes in the appropriate states. The distribution of signals between boxes in the computer system complex can be accomplished without the use of a dedicated wire.

Abstract: According to the present invention, methods and apparatus are provided to allow dynamic multiple cluster system configuration changes. In one example, processors in the multiple cluster system share a virtual address space. Mechanisms for dynamically introducing and removing processors, I/O resources, and clusters are provided. The mechanisms can be implemented during reset or while a system is operating. Links can be dynamically enabled or disabled.

Abstract: Methods and apparatus are provided for improving the distribution of system management signals within a computer system complex. Mechanisms are provided for transmission both within a box and between computer system boxes. Local routing tables and general routing tables allow the distribution of system management signals precisely to resources associated with particular partitions. Signals are sequenced to put resources associated with one or more boxes in the appropriate states. The distribution of signals between boxes in the computer system complex can be accomplished with the use of a dedicated wire.

Abstract: Improved techniques are provided for detecting and correcting errors and skew in inter-cluster communications within computer systems having a plurality of multi-processor clusters. The local nodes of each cluster include a plurality of processors and an interconnection controller. Intra-cluster links are formed between the local nodes, including the interconnection controller, within a cluster. Inter-cluster links are formed between interconnection controllers of different clusters. Intra-cluster packets may be serialized and encapsulated as inter-cluster packets for transmission on inter-cluster links, preferably with link-layer encapsulation. Each inter-cluster packet may include a sequence identifier and error information computed for that packet. Clock data may be embedded in symbols sent on each bit lane of the inter-cluster links. Copies of transmitted inter-cluster packets may be stored until an acknowledgement is received.

Abstract: Improved techniques are provided for reducing latency in inter-cluster communications within computer systems having a plurality of multi-processor clusters. The local nodes of each cluster include a plurality of processors and an interconnection controller. Intra-cluster links are formed between the local nodes, including the interconnection controller, within a cluster. Inter-cluster links are formed between interconnection controllers of different clusters. Intra-cluster packets may be encapsulated as inter-cluster packets and stored in a transmission buffer pending transmission on an inter-cluster link. When the transmission buffer is empty, a control character is transmitted on an inter-cluster link. The control character is not stored in the transmission buffer or in a reception buffer, but instead is dropped. Clock data may be embedded in symbols sent on each bit lane of the inter-cluster links, including the symbol(s) of the control character.

Abstract: A method and apparatus are provided for entering and exiting multiple threads within a multithreaded processor. A state machine is maintained to indicate a respective status of an associated thread of multiple threads being executed within a multithreaded processor. A change of status for a first thread within the multithreaded processor is detected and, responsive to the change of status for the first thread within the multithreaded processor, a partitioning scheme for the functional unit is altered to service a second thread, but not the first thread, within the multithreaded processor when the change of the status of the first thread comprises a transition from an active state to an inactive state.

Abstract: A system includes a multithreaded processor, a memory to store the plurality of threads, and a bus to deliver the plurality of threads to the multithreaded processor. The multithreaded processor includes an event detector to detect a first event indication for a first thread. The event detector, responsive to the detection of the first event indication for the first thread, monitors a second thread being processed within the multithreaded processor to detect a clearing point for the second thread and, responsive to the detection of the clearing point for the second thread clears a functional unit within the multithreaded processor for at least the first thread.

Abstract: A computer system having a plurality of processing nodes interconnected by a first point-to-point architecture is described. Each processing node has a cache memory associated therewith. A probe filtering unit is operable to receive probes corresponding to memory lines from the processing nodes and to transmit the probes only to selected ones of the processing nodes with reference to probe filtering information. The probe filtering information is representative of states associated with selected ones of the cache memories.

Abstract: A multi-processor computer system is described in which address mapping, routing, and transaction identification mechanisms are provided which enable the interconnection of a plurality of multi-processor clusters, wherein the number of processors interconnected exceeds limited address, node identification, and transaction tag spaces associated with each of the individual clusters.

Abstract: A multi-processor computer system is described in which address mapping, routing, and transaction identification mechanisms are provided which enable the interconnection of a plurality of multi-processor clusters, wherein the number of processors interconnected exceeds limited address, node identification, and transaction tag spaces associated with each of the individual clusters.