Abstract: Restoring and/or augmenting neural function may be achieved in some examples by receiving signals associated with a first region of a nervous system, and generating a stimulation pattern based on the signals associated with the first region of the nervous system and a first artificial network. The stimulation pattern may be provided to a second region of the nervous system to induce a behavioral output. In some examples, a second artificial network may be used to train the first artificial network. The second artificial network may be configured to predict the behavioral output from the individual based on the stimulation provided by the first artificial network. Parameters of the first artificial network can be adjusted using the output of the second artificial network to optimize the output signals of the first artificial network to achieve restoration and/or augmentation goals.

Abstract: Systems and methods for promoting neuroplasticity in a brain of a subject to improve and/or restore neural function are disclosed herein. One such method includes detecting residual movement and/or muscular activity in a limb of the subject, such as a paretic limb. The method further includes generating a stimulation pattern based on the detected movement and/or muscular activity, and stimulating the brain of the subject with the stimulation pattern. It is expected that delivering stimulation based on the detected residual movement and/or muscular activity of the limb will induce neuroplasticity for restoring neural function, such as control of the limb. A second method involves detecting brain signals and delivering contingent stimulation. A third method involves delivering pairs of successive stimulus patterns to two brain sites, controlled either by preprogrammed sequences or contingent on neural or muscular activity or movement.

Abstract: Systems and methods for promoting neuroplasticity in a brain of a subject to improve and/or restore neural function are disclosed herein. One such method includes detecting residual movement and/or muscular activity in a limb of the subject, such as a paretic limb. The method further includes generating a stimulation pattern based on the detected movement and/or muscular activity, and stimulating the brain of the subject with the stimulation pattern. It is expected that delivering stimulation based on the detected residual movement and/or muscular activity of the limb will induce neuroplasticity for restoring neural function, such as control of the limb. A second method involves detecting brain signals and delivering contingent stimulation. A third method involves delivering pairs of successive stimulus patterns to two brain sites, controlled either by preprogrammed sequences or contingent on neural or muscular activity or movement.