Abstract: The present application provides methods for the synthesis of intermediates in the synthesis of Safinamide or a pharmaceutically acceptable salt thereof herein Safinamide Mesylate, that is substantially free of impurities.

Abstract: The invention provides implantable drug delivery devices comprising a core comprising a polymer (or polymer blend) and one or more drugs or pharmaceutical substances, and an outer shell comprising a polymer (or polymer blend) and one or more porogen materials. The invention reduces burst release of drug. Pharmaceuticals such as triiodothyronine (T3) or ropinirole can be delivered by the devices.

Abstract: The present disclosure provides a cleansing composition that includes from about 20% to about 40% by weight of a primary anionic surfactant; from about 10% to about 30% by weight of an amphoacetate; from about 10% to about 30% by weight of a sultaine; and from about 0.5% to about 2% by weight of a fatty acid, wherein the amounts are based upon the total weight of the composition and the composition is free of anionic alkyl sulfates and alkyl ether sulfates.

Abstract: The present invention provides compositions, methods, and kits for treatment of opiate addiction and pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine.

Abstract: Examples of the present disclosure describe systems and methods for using online signals to improve judgment quality in Side-by-Side (SBS) evaluation. In aspects, two or more search result lists may be accessed within a query log. The search result lists may be used to generate and/or determine satisfaction metrics between the search result lists. The satisfaction metrics may be aggregated to automatically generate preference judgments for the search result lists. In some aspects, the preference judgments may be compared to the preference judgments of judges to measure the judgment quality of the judges.

Abstract: In accordance with an embodiment, a system and method provides a dynamic clustered messaging service in an application server environment. A cluster includes one or more servers operating within the application server environment and is configured to vary a number of the servers based on a service load of applications running on the cluster. The number also varies based on failure and restart of the servers. A messaging service for communicating messages between components of the applications includes instances of messaging service artifacts running on the one or more servers. A placement engine operating on the cluster is configured to migrate the instances of messaging service artifacts between the one or more servers based on a set of rules as the number of the one or more servers in the cluster expands and contracts and as a number of the instances of messaging service artifacts expands and contracts.

Abstract: The present application is directed to a method and apparatus for processing a transparent or semitransparent material with a laser beam resulting in deterministic separation of a single sheet of the material into two or more pieces.

Abstract: Detergent compositions including: one or more sulfates selected from sodium laureth sulfate, sodium lauryl sulfate, and combinations thereof; disodium ricinoleamido MEA-sulfosuccinate; and one or more sulfobetaines.

Abstract: The present invention comprises compositions, methods and kits for delivering drugs. The invention provides an implantable device for delivery of a pharmaceutical substance to a patient, comprising a core comprising a core polymeric material optionally containing a core pharmaceutical substance, surrounded by a first layer comprising a first-layer pharmaceutical substance and a first-layer polymeric material, optionally surrounded by one or more additional layers comprising an additional pharmaceutical substance and an additional polymeric material, where the core, first, and optional additional polymeric materials may be the same or different, and where the optional core pharmaceutical substance, first-layer pharmaceutical substance, and optional additional pharmaceutical substances are the same or different. Implantation of the device allows a controlled release of drug for an extended period of time. The device may be implanted subcutaneously in an individual in need of continuous treatment with a drug.

Abstract: The present invention comprises compositions, methods and kits for delivering drugs. The invention provides an implantable device for delivery of a pharmaceutical substance to a patient, comprising a core comprising a core polymeric material optionally containing a core pharmaceutical substance, surrounded by a first layer comprising a first-layer pharmaceutical substance and a first-layer polymeric material, optionally surrounded by one or more additional layers comprising an additional pharmaceutical substance and an additional polymeric material, where the core, first, and optional additional polymeric materials may be the same or different, and where the optional core pharmaceutical substance, first-layer pharmaceutical substance, and optional additional pharmaceutical substances are the same or different. Implantation of the device allows a controlled release of drug for an extended period of time. The device may be implanted subcutaneously in an individual in need of continuous treatment with a drug.

Abstract: An aqueous personal care composition comprising: one or more amphoacetates; one or more glutamate surfactants selected from sodium lauroyl glutamate, dipotassium cocoyl glutamate, potassium lauryl/myristoyl glutamate and combinations thereof; and cocamide MIPA; wherein the composition is free of sulfates and ethoxylates.

Abstract: The present invention provides compositions, methods, and kits for treatment of opiate addiction and pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine.

Abstract: The present disclosure provides a cleansing composition that includes a combined amount of disodium alkyl ethoxy dimethicone sulfosuccinate; polyglycerol; and ethoxylated sorbitan ester.

Abstract: Examples of the present disclosure describe systems and methods for using online signals to improve judgment quality in Side-by-Side (SBS) evaluation. In aspects, two or more search result lists may be accessed within a query log. The search result lists may be used to generate and/or determine satisfaction metrics between the search result lists. The satisfaction metrics may be aggregated to automatically generate preference judgments for the search result lists. In some aspects, the preference judgments may be compared to the preference judgments of judges to measure the judgment quality of the judges.

Abstract: The present invention provides compositions, methods, and kits for treatment of opiate addiction and pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine.

Abstract: Novel synthetic approaches to make 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof are provided.

Abstract: The present disclosure provides a cleansing composition that includes from about 20% to about 40% by weight of a primary anionic surfactant; from about 10% to about 30% by weight of an amphoacetate; from about 10% to about 30% by weight of a sultaine; and from about 0.5% to about 2% by weight of a fatty acid, wherein the amounts are based upon the total weight of the composition and the composition is free of anionic alkyl sulfates and alkyl ether sulfates.

Abstract: Techniques for modify a game application without a user request are described herein. A tool chain module can receive, from a first development tool, a first modification code defining a first game modification of a game application on a client device of a user. Additionally, the tool chain module can receive, from a second development tool, a second modification code defining a second game modification of the game application. Furthermore, in an automated operation using one or more computer processors configured to perform the automated operation, the tool chain module can generate a composite modification file based on the first modification code and the second modification code. Subsequently, the tool chain module can transmit the composite modification file to the client device, to enable updating, without a user request from an application store, of the game application on the client device by use of the composite modification file.

Abstract: Techniques for modifying a game application on different client devices are described herein. A tool chain module can receive, from a development tool, a modification code defining a game modification of a game application. The game application can be installed on a first client device and a second client device. Additionally, the tool chain module can generate a modification file based on the modification code. The modification file can define the game modification in a platform-independent format. The modification file can be transmitted to the first client device having a first operating system. Moreover, the modification file can be transmitted to the second client device having a second operating system. The second operating system can be different from the first operating system. Furthermore, the tool chain module can cause an update of the game application, on the first client device and the second client device, using the modification file.

Abstract: Novel synthetic approaches to make 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof are provided.