Patents by Inventor Rajesh R. Naik

Rajesh R. Naik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11058770
    Abstract: A stable protein ionic liquid, comprising an anti-hemoglobin cation/anion pair. The anti-hemoglobin cation/anion pair may be an anionic polymer of poly(ethylene glycol) 4-nonylphenyl 3-sulfopropyl ether. The anti-hemoglobin cation/anion pair may further comprise a cationized anti-hemoglobin antibody, single-chain antibodies from camelids, antibody fragments, polyclonal Anti-horse spleen ferritin antibodies, monoclonal Anti-Flag antibodies, monoclonal Anti-HRP2 to Plasmodium falciparum, polyclonal Anti-neuropeptide Y, polyclonal Anti-human troponin, isotypes of antibodies, or combinations of multiple antibodies.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: July 13, 2021
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Joseph M Slocik, Rajesh R. Naik, Patrick B Dennis
  • Patent number: 10463733
    Abstract: A method for creating a stable protein/antibody ionic liquid, comprising: (a) cationizing aqueous proteins/antibodies by addition of an excess of a positively-charged crosslinker in the presence of a coupling reagent; (b) purifying the cationized proteins/antibodies; (c) titrating the cationized proteins/antibodies with a corresponding biologically-compatible counter anionic polymer to create at least one protein/antibody cation/anion pair in aqueous solution until the cation/anion pair solution becomes negative by zeta potential measurement; (d) repeatedly dialyzing the protein/antibody cation/anion pair in water to remove excess anionic polymer using at least one molecular weight cutoff 7000 dialysis membrane; (e) lyophilizing the protein/antibody cation/anion pair to remove most of the water, forming a lyophilized solid; and (f) heating the lyophilized solid until a protein/antibody ionic liquid is generated. The antibody may be any desired antibody, and the anion may be any biologically-compatible anion.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: November 5, 2019
    Assignee: United States of America as represented by the Secetary of the Air Force
    Inventors: Joseph M. Slocik, Rajesh R. Naik, Patrick B. Dennis
  • Patent number: 9758439
    Abstract: Reactive nanocomposites comprising a metal nanoparticle functionalized with one or more layers of self-assembled protein cages and methods of making the same. The reactive nanocomposites according to the present invention demonstrate improved reaction kinetics and enhanced exothermic behavior.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: September 12, 2017
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Joseph M. Slocik, Christopher A. Krouse, Rajesh R. Naik
  • Publication number: 20170016892
    Abstract: A biomarker sensor using short peptide recognition elements. The biomarker sensor includes a substrate and a metallic layer on a surface of that substrate that is localized surface plasmon resonance reactive. A receptor layer on the surface of the metallic layer (the surface opposing the substrate) is configured to selectively bind a biomarker and has a thickness less than about 15 nm.
    Type: Application
    Filed: July 14, 2016
    Publication date: January 19, 2017
    Applicant: Government of the United States as Represented by the Secretary of the Air Force
    Inventors: Rajesh R. Naik, Joshua A. Hagen, Joshua M. Slocik, Abrin L. Schmucker, Srikanth Singamaneni
  • Patent number: 9187519
    Abstract: Reactive nanocomposites comprising a metal nanoparticle functionalized with one or more layers of self-assembled protein cages and methods of making the same. The reactive nanocomposites according to the present invention demonstrate improved reaction kinetics and enhanced exothermic behavior.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: November 17, 2015
    Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE
    Inventors: Joseph M Slocik, Christopher A Krouse, Rajesh R Naik
  • Patent number: 9028807
    Abstract: A method of forming a biocidal halogenated organic/inorganic composite material may include providing at least one inorganic precursor, providing at least one organic agent, precipitating an organic/inorganic composite material by contacting the at least one inorganic precursor with the at least one organic agent, and halogenating the organic/inorganic composite material by contacting the organic/inorganic composite material with a halogen. Also, a halogenated organic/inorganic composite material may include an inorganic composition comprising a metal oxide and a halogenated organic composition. The inorganic composition and the halogenated organic composition are dispersed throughout the composite material.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 12, 2015
    Assignee: UES, Inc.
    Inventors: Matthew B. Dickerson, Rajesh R. Naik
  • Patent number: 8716029
    Abstract: A biosensor that utilizes carbon nanotubes functionalized with a protein sequence. One domain of the multifunctional peptide sequence noncovalently binds to the surface of single-walled carbon nanotubes (SWNTs), while a second domain of the sequence recognizes and binds to a target molecule. The sequence of the peptide may be tailored to allow it to recognize and bind to specific target molecules, such as chemicals, biological materials, and explosives. The binding of the target molecule to the peptide may alter a material property of the SWNTs.
    Type: Grant
    Filed: September 19, 2011
    Date of Patent: May 6, 2014
    Assignee: The United States of America as represented by the Secretary of the United States
    Inventors: Steve S. Kim, Zhifeng Kuang, Rajesh R. Naik, Barry L. Farmer
  • Patent number: 8445641
    Abstract: Nanocomposites of repeat sequence protein polymers and phyllosilicates demonstrated improved material properties, for example, improved elasticity, and are useful as suture, tissue scaffolding, and biodegradable composite materials.
    Type: Grant
    Filed: August 22, 2006
    Date of Patent: May 21, 2013
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Lawrence F. Drummy, Joseph C. McAuliffe, Rajesh R. Naik, Richard A. Vaia
  • Patent number: 8273319
    Abstract: An improved method for enriched chirality of single wall carbon nanotubes is described. Genomic DNA, particularly salmon DNA (SaDNA) is shown to sort out single wall carbon nanotubes of specific chirality by a process of solubilization (dissolving in solution) and separation (such as centrifuging), without requiring more complex processes such as anion exchange chromatography. A possible reason for enhanced chirality separation using DNA may be attributed to its lowered GC (guanine-cytosine) content.
    Type: Grant
    Filed: July 26, 2010
    Date of Patent: September 25, 2012
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Sang N. Kim, Rajesh R. Naik, James G. Grote, Barry L. Farmer
  • Patent number: 8137597
    Abstract: A one-part, pressure activated chemiluminescent material is disclosed. The free-flowing powder is made by coating microcapsules, filled with a solvent and dye, with a powdered oxalate and a solid source for hydrogen peroxide. The reaction begins when the capsules are crushed, releasing the solvent, which dissolves the oxalate and the source for hydrogen peroxide. The resulting reaction transfers energy to the dye, which produces light.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: March 20, 2012
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Lawrence L. Brott, Brian E. O'Toole, Christopher A. Vaiana, Rajesh R. Naik
  • Patent number: 7976727
    Abstract: This patent covers infrared phosphorescent materials which exhibit extended persistence lifetimes and are composed of mixtures of the elements zinc, antimony, gallium, tellurium, oxygen and nitrogen, and are doped with varying amounts of chromium, neodymium, dysprosium, yttrium or thulium. A typical formula is given by Zn(1-n %-m %-l %)SbxGa2-xTezO4+2z-yNy: n % Cr3+, m % P, l % Q, where Zn is zinc, Sb is antimony, Ga is gallium, Te is tellurium, O is oxygen, N is nitrogen. Additionally, x (0 to 2) y (0 to 0.5) and z (0 to 1) are the molar concentration in the composition. Cr3+ is the doped chromium ion, P is a codopant and Q is a second codopant and n, m, l are the concentration respectively (m,m,l are from 0.1 to 10). An example is the material ZnSbGaTeO5.95N0.05:3% Cr3+, 1% Nd3+, which has an emission peak at 760 nm and a persistent time of over 20 hours (measured with Fluorolog-3 spectrometer with a PMT detector).
    Type: Grant
    Filed: August 25, 2010
    Date of Patent: July 12, 2011
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Rajesh R. Naik, Lawrence L. Brott, George D. Jia
  • Patent number: 7905943
    Abstract: Bimetallic hybrid nanostructures exhibit enhanced properties beyond a single composition nanoparticle, but present technical challenges for synthesis that includes the ability to process two or more materials while offering control over structural arrangement. Unlike conventional synthetic strategies, biological systems are excellent manufacturers of complex inorganic materials which possess maximal functionality, quality, and structures. Using a bio-mediated approach, Applicants have developed a synthetic method for the controlled synthesis of bimetallic nanostructures using multifunctional peptides.
    Type: Grant
    Filed: January 8, 2008
    Date of Patent: March 15, 2011
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Joseph M. Slocik, Rajesh R. Naik
  • Publication number: 20090312455
    Abstract: Nanocomposites of repeat sequence protein polymers and phyllosilicates demonstrated improved material properties, for example, improved elasticity, and are useful as suture, tissue scaffolding, and biodegradable composite materials.
    Type: Application
    Filed: August 22, 2006
    Publication date: December 17, 2009
    Inventors: Lawrence F. Drummy, Joseph C. McAuliffe, Rajesh R. Naik, Richard A. Vaia
  • Publication number: 20080176760
    Abstract: A method is provided for identifying and isolating peptides capable of binding of inorganic materials such as silica, silver, germanium, cobalt, iron, or oxides thereof, or other materials on a nanometric scale such as carbon nanotubes, using a combinatorial phage display peptide library and a polymerase-chain reaction (PCR) step to obtain specific amino acids sequences. In the method of the invention, a combinatorial phage display library is used to isolate and select the desired binding peptides by a series of steps of target binding of phage with the nanometric material of interest, elution and purification of the bound phages, and amplification using PCR to determine the sequences of phages producing the desired binding peptides. The binding peptides of the invention are particularly advantageous in that they may be used as templates to guide the development of useful structures on a nanometric scale.
    Type: Application
    Filed: March 27, 2008
    Publication date: July 24, 2008
    Inventors: Rajesh R. Naik, Morley O. Stone, Daniel C. Carter
  • Patent number: 7314735
    Abstract: A family of reflectin proteins is identified herein that is deposited in flat, structural platelets in reflective tissues of the squid Euprymna scolopes. These proteins are encoded by at least six genes in three subfamilies and have no reported homologues outside of squids. Reflectins possess 5 repeating domains, that are remarkably conserved among members of the family. The proteins have a highly unusual composition with four relatively rare residues (tyrosine, methionine, arginine, and tryptophan) comprising ˜57% of a reflectin, and several common residues (alanine, isoleucine, leucine, and lysine) occurring in none of the family members. These protein-based reflectors in squids provide a striking example of nanofabrication in animal systems.
    Type: Grant
    Filed: March 1, 2005
    Date of Patent: January 1, 2008
    Assignees: The University of Hawaii, The Regents of the University of California, The Governement of the United States of America as represented by the Secretary of the Air Force
    Inventors: Wendy J. Goodson, Margaret McFall-Ngai, Jennifer Kimbell, Joseph Horwitz, Ryan Kramer, Rajesh R. Naik
  • Patent number: 7193037
    Abstract: An apparatus and method for detecting infrared radiation is provided which comprises a temperature-sensing helical coiled-coil protein such as TlpA, CC1, collagen or myosin, incorporated into an electrically conductive film or gel deposited onto an electrically conductive medium such as an electrode, means for recording changes in conductivity or resistance of the conductive film or gel caused by the presence of infrared radiation and the effect of the infrared radiation on the thermal-sensing protein, and means to analyze the changes in conductivity or resistance in the conductive film caused by the infrared radiation so as to determine if infrared radiation is present.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: March 20, 2007
    Assignees: The United States of America as represented by the Secretary of the Air Force, New Century Pharmaceuticals, Inc.
    Inventors: Lawrence L. Brott, Rajesh R. Naik, Morley O. Stone, Daniel C. Carter