Abstract: Biosensors and methods for localized surface plasmon resonance biosensing are disclosed. The biosensor can include a substrate having a substrate surface to which a plurality of localized surface plasmon resonance (LSPR) antennae are affixed. The LSPR antennae can be affixed via an affixation surface of the LSPR antenna. The LSPR antennae can have a functional surface opposite the affixation surface. Each functional surface can be functionalized by a plurality of single-stranded DNA.

Abstract: Biosensors and methods for localized surface plasmon resonance biosensing are disclosed. The biosensor can include a substrate having a substrate surface to which a plurality of localized surface plasmon resonance (LSPR) antennae are affixed. The LSPR antennae can be affixed via an affixation surface of the LSPR antenna. The LSPR antennae can have a functional surface opposite the affixation surface. Each functional surface can be functionalized by a plurality of single-stranded DNA.

Abstract: Biosensors and methods for localized surface plasmon resonance biosensing are disclosed. The biosensor can include a substrate having a substrate surface to which a plurality of localized surface plasmon resonance (LSPR) antennae are affixed. The LSPR antennae can be affixed via an affixation surface of the LSPR antenna. The LSPR antennae can have a functional surface opposite the affixation surface. Each functional surface can be functionalized by a plurality of single-stranded DNA.

Abstract: The invention provides methods and compositions having at least one asymmetrically functionalized nanoparticle. An asymmetrically functionalized nanoparticle can comprise a nanoparticle core having an outer surface, a primary group of first ligands attached to a substantially continuous primary region of the outer surface, and a secondary group of second ligands attached to a substantially continuous secondary region of the outer surface, such that the primary group of first ligands and the secondary group of second ligands comprise a different ligand population.

Abstract: The invention provides methods and compositions having one-dimensional nanoparticle chains. A one-dimensional nanoparticle chain can comprise a linear substantially non-crosslinked polymer having pendant groups and asymmetrically functionalized nanoparticles attached to the polymer through the pendant groups. Additionally, an asymmetrically functionalized nanoparticle can comprise a nanoparticle core having an outer surface, a primary group of first ligands attached to a substantially continuous primary region of the outer surface, and a secondary group of second ligands attached to a substantially continuous secondary region of the outer surface, such that the primary group of first ligands and the secondary group of second ligands comprise a different ligand population.

Abstract: A method of synthesizing ligand-capped metal nanoparticles is disclosed and described. A method of synthesizing ligand-capped metal nanoparticles can comprise reacting a metal salt with 9-borabicyclo [3.3.1] nonane as a reducing agent in the presence of a capping ligand to form the ligand-capped metal nanoparticles. The method can be a single step approach which also significantly broadens choices for capping agents which can be readily incorporated during formation of the metal nanoparticles.

Abstract: The invention provides methods and compositions having at least one asymmetrically functionalized nanoparticle. An asymmetrically functionalized nanoparticle can comprise a nanoparticle core having an outer surface, a primary group of first ligands attached to a substantially continuous primary region of the outer surface, and a secondary group of second ligands attached to a substantially continuous secondary region of the outer surface, such that the primary group of first ligands and the secondary group of second ligands comprise a different ligand population.

Abstract: The invention provides methods and compositions having one-dimensional nanoparticle chains. A one-dimensional nanoparticle chain can comprise a linear substantially non-crosslinked polymer having pendant groups and asymmetrically functionalized nanoparticles attached to the polymer through the pendant groups. Additionally, an asymmetrically functionalized nanoparticle can comprise a nanoparticle core having an outer surface, a primary group of first ligands attached to a substantially continuous primary region of the outer surface, and a secondary group of second ligands attached to a substantially continuous secondary region of the outer surface, such that the primary group of first ligands and the secondary group of second ligands comprise a different ligand population.