Abstract: The present invention provides an inhaler device (1) for dispensing doses of medicament, the inhaler comprising means for receiving a compartment (42) containing medicament; and medicament extraction facilitating means (22) for locating in a received compartment (42) and thereby allowing an extraction of medicament from said compartment (42); wherein the extraction facilitating means (22) comprises (i) a first fluid pathway extending therethrough for directing extracted medicament to an outlet of the inhaler (1) and (ii) means which, in use, provides a second fluid pathway for directing fluid into said compartment (42) past a sealing material of the compartment (42) pierced by said extraction facilitating means (22).

Abstract: The present invention provides a stable aerosol pharmaceutical formulation of a beta-agonist, an anticholinergic, or a combination thereof in combination with a cosolvent and optionally a surfactant. The invention also provides a method of making the stable aerosol pharmaceutical formulation and methods of treating bronchoconstriction, asthma and related conditions with the stable aerosol pharmaceutical formulation of the present invention.

Abstract: The present invention provides a stable aerosol pharmaceutical formulation of a beta-agonist, an anticholinergic, or a combination thereof in combination with a cosolvent and optionally a surfactant. The invention also provides a method of making the stable aerosol pharmaceutical formulation and methods of treating bronchoconstriction, asthma and related conditions with the stable aerosol pharmaceutical formulation of the present invention.