Abstract: A method, system, and computer program product for securing wireless network devices improves the security of wireless networks and devices, such as Bluetooth networks and devices, to prevent security attacks on and hacking of such networks and devices. A method for secure wireless communications, comprises the steps of requesting a connection with a wireless device, determining whether the wireless device is trusted, determining a security policy of the wireless device, and establishing a connection with the wireless device if the wireless device is trusted and if the security policy of the wireless device is as expected.

Abstract: Provided herein are use of polymeric excipients, specifically polyvinyl alcohols, optionally in conjunction with sugars, as cryoprotectants to prevent aggregation of PEG-containing particles. Also provided are PEG-containing particles comprising such polymeric excipients.

Abstract: Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.

Abstract: The present disclosure relates to novel pharmaceutical compositions comprising a nanoparticle associated with, tether to, or encapsulating a platinum-based active pharmaceutical agent. The platinum-based drug is released from the nanoparticles in a controlled fashion. Also contemplated are methods of making the nanoparticles, as well as methods for using them in the treatment or prevention of diseases or conditions. One embodiment relates to phenanthriplatin nanoparticles and methods of using and making the same.

Abstract: A method, system, and computer program product for scanning incoming emails reduces the server resources needed, which improves server throughput and reduces costs. A method for processing incoming email messages comprised the steps of scanning incoming email messages to obtain an address of a sender of each incoming email message and to determine whether the email message is spam, for each email message that is determined to be spam, incrementing a count of email messages that are spam for a sender of the email message, determining that a count of email messages that are spam for a sender of an email message has exceeded a threshold, and thereafter, discarding all incoming email messages from the sender for which the count of email messages that are spam for a sender of an email message has exceeded a threshold without scanning the email messages to determine whether they are spam.

Abstract: A method, system, and computer program product for scanning incoming emails reduces the server resources needed, which improves server throughput and reduces costs. A method for processing incoming email messages comprised the steps of scanning incoming email messages to obtain an address of a sender of each incoming email message and to determine whether the email message is spam, for each email message that is determined to be spam, incrementing a count of email messages that are spam for a sender of the email message, determining that a count of email messages that are spam for a sender of an email message has exceeded a threshold, and thereafter, discarding all incoming email messages from the sender for which the count of email messages that are spam for a sender of an email message has exceeded a threshold without scanning the email messages to determine whether they are spam.

Abstract: A system, method, and computer program product are provided for optimizing network browser performance by conditionally loading a portion of data from a network based on a data transfer rate. In use, a data transfer rate associated with a device connected to a network is identified. Additionally, a portion of data from the network is conditionally loaded utilizing a network browser of the device, based on the identified data transfer rate. Further, the portion of the data is selected based on a relevancy of the portion of the data.

Abstract: A system, method, and computer program product are provided for conditionally allowing a transfer of content, based on a signature and a context. In operation, a signature for content is identified. In addition, a context of an attempt to transfer the content is identified. Furthermore, the transfer is conditionally allowed, based on the signature and the context.

Abstract: A system, method, and computer program product are provided for optimizing network browser performance by conditionally loading a portion of data from a network based on a data transfer rate. In use, a data transfer rate associated with a device connected to a network is identified. Additionally, a portion of data from the network is conditionally loaded utilizing a network browser of the device, based on the identified data transfer rate. Further, the portion of the data is selected based on a relevancy of the portion of the data.

Abstract: A system, method, and computer program product are provided for communicating automatic response messages based on a policy. In use, use of an automatic message generator utilized for automatically responding to receipt of a first message using a second message is identified. Additionally, it is determined whether a characteristic of at least one of the first message and the second message violates a predetermined policy. Furthermore, the second message is conditionally communicated based on the determination.

Abstract: A system, method, and computer program product are provided for generating an alert based on information describing at least one update associated with an application to be repaired. In operation, a request to repair an application is received. Additionally, information describing at least one update associated with the application is identified. Furthermore, an alert is generated based on the information.

Abstract: A method, system, and computer program product for securing wireless network devices improves the security of wireless networks and devices, such as Bluetooth networks and devices, to prevent security attacks on and hacking of such networks and devices. A method for secure wireless communications, comprises the steps of requesting a connection with a wireless device, determining whether the wireless device is trusted, determining a security policy of the wireless device, and establishing a connection with the wireless device if the wireless device is trusted and if the security policy of the wireless device is as expected.

Abstract: A method, system, and computer program product for scanning incoming emails reduces the server resources needed, which improves server throughput and reduces costs. A method for processing incoming email messages comprised the steps of scanning incoming email messages to obtain an address of a sender of each incoming email message and to determine whether the email message is spam, for each email message that is determined to be spam, incrementing a count of email messages that are spam for a sender of the email message, determining that a count of email messages that are spam for a sender of an email message has exceeded a threshold, and thereafter, discarding all incoming email messages from the sender for which the count of email messages that are spam for a sender of an email message has exceeded a threshold without scanning the email messages to determine whether they are spam.

Abstract: Compositions and methods are provided for preparing nanosized biologically active agents, including agents formulated for target specific drug delivery. The nanosized agents are prepared with supercritical carbon dioxide as an antisolvent, providing nanoparticles whose size, shape, and surroundings are well-controlled. The nanoparticles are made of small molecules, e.g. drugs, anti-oxidants, luciferin, polypeptides, e.g. oligopeptides; polynucleotides, e.g. siRNA, antisense oligonucleotides, etc. In some embodiments, the nanoparticles comprise a polymer coating, which can provide for controlled delivery, targeting, controlled release, and the like. In other embodiments, the nanoparticles comprise a target specific tag for targeting the nanoparticles to a site of interest, e.g. tissue, cell, etc.

Abstract: A system (20) and method are disclosed for the self-calibrating, on-line determination of size distribution f(x) and volume fraction ? of a number of particles (P) dispersed in a medium (M) by detecting one or more propagation characteristics of multiply scattered light from the particles (P). The multiply scattered light is re-emitted in response to exposure to a light source (21) configured to provide light at selected wavelengths. The determination includes calculating the isotropic scattering and absorption coefficients for the particles (P) by comparing the incident and detected light to determine a measurement corresponding to the propagation time through the scattering medium (M), and iteratively estimating the size distribution f(x) and volume fraction ? as a function of the coefficients for each of the wavelengths. An estimation approach based on an expected form of the distribution and the mass of the particles is also disclosed.

Abstract: Provided are luciferyl peptide substrates that are produced by attaching specifically prepared peptide conjugates to luciferin, and/or its analogs and derivatives. The luciferyl peptide substrates are incapable of penetrating cell membranes and tissue barriers. Cleavage of the peptide conjugates from the luciferyl peptide substrates releases the luciferin, which upon contact with luciferase emits photons for easy detection. The luciferyl peptide substrates may be used in assays to detect pathogens, test protease inhibitors, probe cell physiology, assess protease activity in oncogenesis, and improve specific and regulated drug delivery.