Patents by Inventor Rajesh Thotapally

Rajesh Thotapally has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic GPR119 modulators
    Patent number: 9000175
    Abstract: The present invention relates to compounds of Formula (I) that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of GPR119 receptor activity. The invention also relates to the process for preparation of the compounds, pharmaceutical compositions thereof. The invention further relates to methods of treating, preventing and/or managing diseases, disorders syndromes or conditions associated with the modulation of GPR119 receptor by using either alone or in combinations of Formula (I).
    Type: Grant
    Filed: November 24, 2011
    Date of Patent: April 7, 2015
    Assignee: Lupin Limited
    Inventors: Rajesh Thotapally, Onkar Gangaram Kachi, Atish Harishchandra Rodge, Ashok Bhau Pathak, Bhavana Shrirang Kardile, Milind Dattatraya Sindkhedkar, Venkata P. Palle, Rajender Kumar Kamboj
  • BICYCLIC GPR119 MODULATORS
    Publication number: 20130245000
    Abstract: The present invention relates to compounds of Formula (I) that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of GPR119 receptor activity. The invention also relates to the process for preparation of the compounds, pharmaceutical compositions thereof. The invention further relates to methods of treating, preventing and/or managing diseases, disorders syndromes or conditions associated with the modulation of GPR119 receptor by using either alone or in combinations of Formula (I).
    Type: Application
    Filed: November 24, 2011
    Publication date: September 19, 2013
    Applicant: LUPIN LIMITED
    Inventors: Rajesh Thotapally, Onkar Gangaram Kachi, Atish Harishchandra Rodge, Ashok Bhau Pathak, Bhavana Shrirang Kardile, Milind Dattatraya Sindkhedkar, Venkata P. Palle, Rajender Kumar Kamboj
  • Heteropyrrole analogs acting on cannabinoid receptors
    Patent number: 8410097
    Abstract: Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or the CB2 cannabinoid receptors. One aspect discloses hetero pyrrole analogs acting as antagonists for the CB1 and/or the CB2 receptors. Another aspect discloses hetero pyrrole analogs having selectivity for the CB1 or CB2 cannabinoid receptor. Also disclosed are pharmaceutical preparations employing the disclosed analogs and methods of administering therapeutically effective amounts of the disclosed analogs to provide a physiological effect.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: April 2, 2013
    Assignee: University of Connecticut
    Inventors: Alexandros Makriyannis, Rajesh Thotapally, Venkata Kiran Rao Vemuri, Teresa Olszewska
  • Novel Heteropyrrole Analogs Acting on Cannabinoid Receptors
    Publication number: 20120095047
    Abstract: Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or the CB2 cannabinoid receptors. One aspect discloses hetero pyrrole analogs acting as antagonists for the CB1 and/or the CB2 receptors. Another aspect discloses hetero pyrrole analogs having selectivity for the CB1 or CB2 cannabinoid receptor. Also disclosed are pharmaceutical preparations employing the disclosed analogs and methods of administering therapeutically effective amounts of the disclosed analogs to provide a physiological effect.
    Type: Application
    Filed: December 22, 2011
    Publication date: April 19, 2012
    Applicant: UNIVERSITY OF CONNECTICUT
    Inventors: Alexandros Makriyannis, Rajesh Thotapally, Venkata Kiran Rao Vemuri, Teresa Olszewska
  • Pyrazole derivatives as cannabinoid receptor antagonists
    Patent number: 8084467
    Abstract: One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or selectivities for the CB1 cannabinoid receptor. A further aspect of the invention is concerned with pharmaceutical preparations employing the inventive analogs and methods of administering therapeutically effective amounts of the inventive analogs to provide a physiological effect.
    Type: Grant
    Filed: June 24, 2005
    Date of Patent: December 27, 2011
    Assignee: University of Connecticut
    Inventors: Alexandros Makriyannis, Qian Liu, Rajesh Thotapally, Venkata Kiran Vemuri
  • Pyrazole analogs acting on cannabinoid receptors
    Patent number: 7745440
    Abstract: One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or selectivities for the CB1 cannabinoid receptor. A further aspect of the invention is concerned with pharmaceutical preparations employing the inventive analogs and methods of administering therapeutically effective amounts of the inventive analogs to provide a physiological effect.
    Type: Grant
    Filed: October 6, 2005
    Date of Patent: June 29, 2010
    Assignee: University of Connecticut
    Inventors: Alexandros Makriyannis, Qian Liu, Rajesh Thotapally
  • NOVEL HETEROPYRROLE ANALOGS ACTING ON CANNABINOID RECEPTORS
    Publication number: 20100063050
    Abstract: Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or the CB2 cannabinoid receptors. One aspect discloses hetero pyrrole analogs acting as antagonists for the CB1 and/or the CB2 receptors. Another aspect discloses hetero pyrrole analogs having selectivity for the CB1 or CB2 cannabinoid receptor. Also disclosed are pharmaceutical preparations employing the disclosed analogs and methods of administering therapeutically effective amounts of the disclosed analogs to provide a physiological effect.
    Type: Application
    Filed: January 10, 2006
    Publication date: March 11, 2010
    Inventors: Alexandros Makriyannis, Rajesh Thotapally, Venkata Kiran Rao Vemuri, Teresa Olszewska
  • Pyrazole analogs acting on cannabinoid receptors
    Patent number: 7393842
    Abstract: One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or selectivities for the CB1 cannabinoid receptor. A further aspect of the invention is concerned with pharmaceutical preparations employing the inventive analogs and methods of administering therapeutically effective amounts of the inventive analogs to provide a physiological effect.
    Type: Grant
    Filed: March 1, 2004
    Date of Patent: July 1, 2008
    Assignee: University of Connecticut
    Inventors: Alexandros Makriyannis, Qian Liu, Rajesh Thotapally
  • Pyrazole derivatives as cannabinoid receptor antagonists
    Publication number: 20060100208
    Abstract: One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or selectivities for the CB1 cannabinoid receptor. A further aspect of the invention is concerned with pharmaceutical preparations employing the inventive analogs and methods of administering therapeutically effective amounts of the inventive analogs to provide a physiological effect.
    Type: Application
    Filed: June 24, 2005
    Publication date: May 11, 2006
    Inventors: Alexandros Makriyannis, Qian Liu, Rajesh Thotapally
  • Novel pyrazole analogs acting on cannabinoid receptors
    Publication number: 20060030563
    Abstract: One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or selectivities for the CB1 cannabinoid receptor. A further aspect of the invention is concerned with pharmaceutical preparations employing the inventive analogs and methods of administering therapeutically effective amounts of the inventive analogs to provide a physiological effect.
    Type: Application
    Filed: October 6, 2005
    Publication date: February 9, 2006
    Inventors: Alexandros Makriyannis, Qian Liu, Rajesh Thotapally
  • Novel pyrazole analogs acting on cannabinoid receptors
    Publication number: 20040192667
    Abstract: One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or selectivities for the CB1 cannabinoid receptor. A further aspect of the invention is concerned with pharmaceutical preparations employing the inventive analogs and methods of administering therapeutically effective amounts of the inventive analogs to provide a physiological effect.
    Type: Application
    Filed: March 1, 2004
    Publication date: September 30, 2004
    Applicant: University of Connecticut
    Inventors: Alexandros Makriyannis, Qian Liu, Rajesh Thotapally