Patents by Inventor Rajesh Vyas

Rajesh Vyas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SALTS OF OBETICHOLIC ACID
    Publication number: 20180099991
    Abstract: The invention relates to salts of Obeticholic Acid, their amorphous and crystalline polymorphic form and processes for preparation thereof.
    Type: Application
    Filed: October 9, 2017
    Publication date: April 12, 2018
    Inventors: Palash Sanphui, Radhakrishna Bhikaji Shivdavkar, Rajesh Vyas, Nandu Baban Bhise, Girij Pal Singh
  • Process for preparation of darunavir and darunavir ethanolate of fine particle size
    Patent number: 9062065
    Abstract: The present invention provides a novel process for preparation of darunavir that involves reduction of [(1S,2R)-3-[[(4-nitrophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester, of formula (5). The present invention also provides darunavir ethanolate of particle size wherein d0.9 is less than 130 ?m, d0.5 is less than 30 ?m, d0.1 is less than 10 ?m and process for its preparation.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: June 23, 2015
    Assignee: LUPIN LIMITED
    Inventors: Vijay Ahire, Sachin Sasane, Amol Deshmukh, Krishnat Kumbhar, Akshat Bhatnagar, Devendra Verma, Rajesh Vyas, Girij Pal Singh, Nandu Bhise
  • Process for preparation of darunavir and darunavir ethanolate of fine particle size
    Patent number: 9062067
    Abstract: The present invention provides a novel process for preparation of darunavir that involves reduction of [(1S,2R)-3-[[(4-nitrophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester, of formula (5). The present invention also provides darunavir ethanolate of particle size wherein d0.9 is less than 130 ?m, d0.5 is less than 30 ?m, d0.1 is less than 10 ?m and process for its preparation.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: June 23, 2015
    Assignee: LUPIN LIMITED
    Inventors: Vijay Ahire, Sachin Sasane, Amol Deshmukh, Krishnat Kumbhar, Akshat Bhatnagar, Devendra Verma, Rajesh Vyas, Girij Pal Singh, Nandu Bhise
  • NOVEL PROCESS FOR PREPARATION OF DARUNAVIR AND DARUNAVIR ETHANOLATE OF FINE PARTICLE SIZE
    Publication number: 20140066638
    Abstract: The present invention provides a novel process for preparation of darunavir that involves reduction of [(1S,2R)-3-[[(4-nitrophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester, of formula (5). The present invention also provides darunavir ethanolate of particle size wherein d0.9 is less than 130 ?m, d0.5 is less than 30 ?m, d0.1 is less than 10 ?m and process for its preparation.
    Type: Application
    Filed: November 8, 2013
    Publication date: March 6, 2014
    Applicant: Lupin Limited
    Inventors: Vijay AHIRE, Sachin SASANE, Amol DESHMUKH, Krishnat KUMBHAR, Akshat BHATNAGAR, Devendra VERMA, Rajesh VYAS, Girij Pal SINGH, Nandu BHISE
  • PROCESS FOR PREPARATION OF ESTRADIOL VALERATE AND A NOVEL CRYSTALLINE FORM A OF ESTRADIOL DIVALERATE
    Publication number: 20130225845
    Abstract: The present invention relates to the process for the preparation of estradiol valerate (I) which involves isolation of crystalline estradiol divalerate (III) by crystallization from an alcoholic solvent.
    Type: Application
    Filed: October 28, 2011
    Publication date: August 29, 2013
    Applicant: LUPIN LIMITED
    Inventors: Sachin Arun Sasane, Vijay Ashok Ahire, Rajesh Vyas, Nandu Baban Bhise, Girij Pal Singh
  • NOVEL PROCESS FOR PREPARATION OF DARUNAVIR AND DARUNAVIR ETHANOLATE OF FINE PARTICLE SIZE
    Publication number: 20120237770
    Abstract: The present invention provides a novel process for preparation of darunavir that involves reduction of [(1S,2R)-3-[[(4-nitrophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy -1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester, of formula (5). The present invention also provides darunavir ethanolate of particle size wherein d0.9 is less than 130 ?m, d0.5 is less than 30 ?m, d0.1 is less than 10 ?m and process for its preparation.
    Type: Application
    Filed: November 1, 2010
    Publication date: September 20, 2012
    Applicant: Lupin Limited
    Inventors: Vijay Ahire, Sachin Sasane, Amol Deshmukh, Krishnat Kumbhar, Akshat Bhatnagar, Devendra Verma, Rajesh Vyas, Girij Pal Singh, Nandu Bhise
  • Process for the preparation of thiazole intermediate
    Patent number: 6833459
    Abstract: The present invention provides a process for the preparation of 4-methyl-5-formyl-thiazole of the formula (I) which comprises reducing the thiazole ester of the formula (III) to thiazole alcohol of the formula (IV), using sodium borohydride in the presence of AlCl3 in a solvent and oxidising using an oxidizing agent the thiazole alcohol of the formula (IV) to obtain 4-methyl-5-formyl-thiazole of the formula (I).
    Type: Grant
    Filed: December 5, 2002
    Date of Patent: December 21, 2004
    Assignee: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Rajesh Vyas, Ramakrishna Kamma
  • Process for the preparation of thiazole intermediate
    Publication number: 20030204095
    Abstract: The present invention provides a process for the preparation of 4-methyl-5-formyl-thiazole of the formula (I) 1
    Type: Application
    Filed: December 5, 2002
    Publication date: October 30, 2003
    Applicant: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Rajesh Vyas, Ramakrishna Kamma