Patents by Inventor Rajeshwar P. Mookerjee

Rajeshwar P. Mookerjee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT
    Publication number: 20130237557
    Abstract: The present invention derives from the finding that increased levels of alpha 2a adrenergic receptors (ADRA2a) are associated with chronic liver disease and that by decreasing ADRA2a levels in vivo, a number of symptoms and consequences of chronic liver disease may be reduced. Accordingly, the invention provides ADRA2a antagonists for use in a method of treating an individual suffering from liver disease.
    Type: Application
    Filed: August 12, 2011
    Publication date: September 12, 2013
    Applicant: UCL BUSINESS PLC
    Inventors: Rajeshwar P. Mookerjee, Vikram Sharma, Rajiv Jalan
  • Biomarkers for assessing liver function
    Patent number: 8455220
    Abstract: A method for assessing liver function in an individual, which method comprises determining the level of methylarginine(s) (such as ADMA and/or SDMA) and the ratio of ischemia modified albumin (IMA): albumin ratio (IMAR) in the individual, thereby to assess liver function in the individual.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: June 4, 2013
    Assignee: UCL Business PLC
    Inventors: Rajiv Jalan, Rajeshwar P Mookerjee, Nathan Davies
  • Prognosis and therapy of liver failure
    Patent number: 8415117
    Abstract: A method for assessing prognosis in an individual suffering from liver failure, which method comprises detecting endotoxin in the individual, for example by determining the neutrophil function in the individual. The method can be used to determine whether there is an increased risk of infection in the individual, an increased risk of organ failure in the individual, an increased risk of mortality in the individual and/or an increased risk that the individual will not respond positively to treatment with an immunosuppressive agent, a steroid or an antibiotic.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: April 9, 2013
    Assignee: UCL Business PLC
    Inventors: Rajiv Jalan, Rajeshwar P Mookerjee, Vanessa Stadlbauer, Nathan Davies
  • Screening Method and Therapy with Agonists of DDAH I
    Publication number: 20120237503
    Abstract: The present invention derives from the finding that decreased levels of DDAH I are associated with increased portal pressure and that by increasing DDAH I levels in vivo, portal pressure may be reduced. Accordingly, the invention provides methods for reducing portal blood pressure comprising administering to a subject in need thereof an agonist of DDAH I.
    Type: Application
    Filed: September 9, 2010
    Publication date: September 20, 2012
    Applicant: UCL BUSINESS PLC
    Inventors: Rajeshwar P. Mookerjee, Rajiv Jalan, Gautam Mehta
  • Prognosis and therapy of liver failure
    Publication number: 20100297018
    Abstract: A method for assessing prognosis in an individual suffering from liver failure, which method comprises detecting endotoxin in the individual, for example by determining the neutrophil function in the individual. The method can be used to determine whether there is an increased risk of infection in the individual, an increased risk of organ failure in the individual, an increased risk of mortality in the individual and/or an increased risk that the individual will not respond positively to treatment with an immunosuppressive agent, a steroid or an antibiotic.
    Type: Application
    Filed: October 29, 2007
    Publication date: November 25, 2010
    Applicant: UCL Business PLC
    Inventors: Rajiv Jalan, Rajeshwar P. Mookerjee, Vanessa Stadlbauer, Nathan Davies
  • BIOMARKERS FOR ASSESSING LIVER FUNCTION
    Publication number: 20090280519
    Abstract: A method for assessing liver function in an individual, which method comprises determining the level of methylarginine(s) (such as ADMA and/or SDMA) and the ratio of ischemia modified albumin (IMA):albumin ratio (IMAR) in the individual, thereby to assess liver function in the individual.
    Type: Application
    Filed: September 7, 2007
    Publication date: November 12, 2009
    Inventors: Rajiv Jalan, Rajeshwar P. Mookerjee, Nathan Davies