Abstract: A method for identifying, quantifying, classifying, and reducing resource waste in an organization is provided. The method includes: receiving a request from a user for identifying waste in a first software development project; identifying a set of tasks to be performed within the first software development project; determining, for each task, whether a waste of a resource such as cost and/or time has occurred; using Jira to tag each task for which a waste has been identified; and generating a report that indicates a result of the determination. The resulting report may be used to pinpoint a friction point within the organization.

Abstract: The present invention relates to compound of Formula 1 for use in treating IPF, by reducing collagen deposition in lungs, attenuating the fibrotic marker's expression (in IPF cell-lines Bleomycin induced rat lungs) and improving the bleomycin induced pathological changes in rat lungs, and ARDS, by reducing the cytokine storm. The invention also relates to compound of Formula 1 for use in treating various fibrotic disorders like lung injuries caused by virus or bacterial infections, cardiac, hepatic and kidney fibrosis.

Abstract: The present disclosure provides a process for preparation of 3,6-dichlorocyano pyrazine, 3,6-dioxopiperizine derivatives and production of favipiravir via ammonia or amine-mediated cyclization and chlorination using POCl3 in the presence of pyridine or PCl5. [Formula] wherein in 3,6-dioxopiperazine derivatives (III), X is CN, CONH2 or COOR2?, R1, R2 and R2? are individually selected from H, C1-C12 alkyl, COOR3 and SO2R3 wherein R3 is substituted or unsubstituted linear or branched lower alkyl.

Abstract: The present invention relates to an enzymatic process for preparation of optically pure enantiomers of homopropargylic alcohol compounds of formula I, which are useful intermediates for the synthesis of Halichondrin B and analogs. wherein, P is H or an alcohol protecting group, n is an integer ranging from 0-12.

Abstract: A method for identifying, quantifying, classifying, and reducing resource waste in an organization is provided. The method includes: receiving a request from a user for identifying waste in a first software development project; identifying a set of tasks to be performed within the first software development project; determining, for each task, whether a waste of a resource such as cost and/or time has occurred; using Jira to tag each task for which a waste has been identified; and generating a report that indicates a result of the determination. The resulting report may be used to pinpoint a friction point within the organization.

Abstract: Distress models can be generated to model current or future deterioration of components. By correlating distress models with maintenance costs and material consumption, cumulative cost models and cumulative material models can be developed to optimize engine removal timing in order to maximize asset and portfolio value.

Abstract: Sulfonyl hydroxamic acid compounds have the following general formula: Ring A and B are aryl, heteroaryl, cycloalkyl, fused aryl or fused alkyl group, and R1, R2, R3, R4, R5, and R6 are hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl, aryl, heteroaryl, halogen, hydroxy, alkoxy, aryloxy, nitro, cyano, ester, or aldehyde. The compounds are HDAC inhibitors. Processes can be used for preparation of these indole-based sulfonyl hydroxamic acid derivatives.

Abstract: Distress models can be generated to model current or future deterioration of components. By correlating distress models with maintenance costs and material consumption, cumulative cost models and cumulative material models can be developed to optimize engine removal timing in order to maximize asset and portfolio value.

Abstract: A method for determining a condition of a second component of an engine is disclosed wherein the engine includes at least a first component and the second component. The method includes determining a concentration value of a chemical species in an effluent obtained from washing at least a portion of the first component of the engine, inputting the concentration value of the chemical species in a condition assessment model to update the condition assessment model, and estimating the condition of the second component based on an output of the updated condition assessment model. The effluent used herein includes a wash fluid and the chemical species. The second component is different from the first component and the condition assessment model is a representative of a condition of the second component of the engine.

Abstract: Sulfonyl hydroxamic acid compounds have the following general formula: Ring A and B are aryl, heteroaryl, cycloalkyl, fused aryl or fused alkyl group, and R1, R2, R3, R4, R5, and R6 are hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl, aryl, heteroaryl, halogen, hydroxy, alkoxy, aryloxy, nitro, cyano, ester, or aldehyde. The compounds are HDAC inhibitors. Processes can be used for preparation of these indole-based sulfonyl hydroxamic acid derivatives.

Abstract: Deployment of UICCs in IoT and M2M devices requires that the interface between UICC functions reliably in extreme temperature conditions. Extreme conditions may cause communication failures between the UICC and its device. The present application proposes various methods and devices for automatic recovery from UICC failure and UICC communication failures, commonly associated with extreme conditions (e.g., high temperature, low temperature, physical shock). The automatic recovery procedure includes applying one or more increased drive strength to the identity card, and may further include varying voltage and/or clock rate.

Abstract: Distress models can be generated to model current or future deterioration of components. By correlating distress models with maintenance costs and material consumption, cumulative cost models and cumulative material models can be developed to optimize engine removal timing in order to maximize asset and portfolio value.

Abstract: Deployment of UICCs in IoT and M2M devices requires that the interface between UICC functions reliably in extreme temperature conditions. Extreme conditions may cause communication failures between the UICC and its device. The present application proposes various methods and devices for automatic recovery from UICC failure and UICC communication failures, commonly associated with extreme conditions (e.g., high temperature, low temperature, physical shock). The automatic recovery procedure includes applying one or more increased drive strength to the identity card, and may further include varying voltage and/or clock rate.

Abstract: The present invention describes the C5,C6 Substituted and/or fused oxindole compounds useful as anti-cancer agents and process for preparation thereof. Particularly the present invention relates to C5,C6 Substituted and/or fused oxindole compounds of formula I.

Abstract: A method for determining a condition of a second component of an engine is disclosed wherein the engine includes at least a first component and the second component. The method includes determining a concentration value of a chemical species in an effluent obtained from washing at least a portion of the first component of the engine, inputting the concentration value of the chemical species in a condition assessment model to update the condition assessment model, and estimating the condition of the second component based on an output of the updated condition assessment model. The effluent used herein includes a wash fluid and the chemical species. The second component is different from the first component and the condition assessment model is a representative of a condition of the second component of the engine.

Abstract: Distress models can be generated to model current or future deterioration of components. By correlating distress models with maintenance costs and material consumption, cumulative cost models and cumulative material models can be developed to optimize engine removal timing in order to maximize asset and portfolio value.

Abstract: The present invention describes the C5,C6 Substituted and/or fused oxindole compounds useful as anti-cancer agents and process for preparation thereof. Particularly the present invention relates to C5,C6 Substituted and/or fused oxindole compounds of formula I.

Abstract: Described herein is pure amorphous darunavir, methods of making pure amorphous darunavir and pharmaceutical compositions containing amorphous darunavir and a pharmaceutically acceptable excipient.

Abstract: The present invention provides novel solvated forms of darunavir and processes for their preparation. The present invention also provides novel processes for the preparation of darunavir amorphous form and pharmaceutical compositions comprising it. Thus, for example, darunavir 2-methyl-2-butanol solvate was dissolved in methylene dichloride, distilled under vacuum at 45° C. to obtain a residue, cyclohexane was added to the residue and stirred for 30 hours at 20 to 25° C., and the separated solid was filtered, washed with cyclohexane and dried under vacuum at 50° C. for 12 hours to yield darunavir amorphous form.

Abstract: A method for performing emergency calls includes: camping a first subscription of a mobile communication device on a first cell on a first communication network; camping a second subscription of the mobile communication device on a second cell on a second communication network; determining by the mobile communication device whether one of the first and second subscriptions supports emergency calls; and initiating an emergency call on the determined subscription.