Abstract: Optical fibers containing wet-spun multi-layer hydrogel cladding with ionic-crosslinked polysaccharides are provided. Optical fibers can be formed with step- or gradient-index architectures, fusion splicing, and facile rare-earth ion doping. Plasmonic nanoparticles, functionalized light-sensitive quantum dots, or particles can be incorporated into the fiber core to generate a resonance light shift upon the presence and binding of molecular biotargets for biosensor applications. The integration of plasmonic hydrogel fibers with medical swabs provides for rapid detection of pathogens such as severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). The inclusion of living cells allows for the non-invasive digitalization and quantification of complex biological responses such as cancer proliferative invasion and discovery of anti-cancer drug susceptibility thresholds.

Abstract: A system and method are provided including a coating method and apparatus using a dielectrophoretic fluid movement system to coat with a non-conducting fluid along a surface that includes a non-conducting surface to receive the non-conducting fluid and a first and second array of one or more substantially parallel microelectrodes positioned on the surface, said first array having microelectrode(s) positioned between, and alternating with, the microelectrode(s) of the second array, forming an interleaved pattern as well as an electric power source in communication with the first array and second array so that the first array and second array interact to create a non-uniform electric field such that the non-conducting fluid moves parallel to the microelectrodes in response to the applied non-uniform electric field.

Abstract: A system and method are provided including a coating method and apparatus using a dielectrophoretic fluid movement system to coat with a non-conducting fluid along a surface that includes a non-conducting surface to receive the non-conducting fluid and a first and second array of one or more substantially parallel microelectrodes positioned on the surface, said first array having microelectrode(s) positioned between, and alternating with, the microelectrode(s) of the second array, forming an interleaved pattern as well as an electric power source in communication with the first array and second array so that the first array and second array interact to create a non-uniform electric field such that the non-conducting fluid moves parallel to the microelectrodes in response to the applied non-uniform electric field.

Abstract: A system and method are provided including a coating method and apparatus using a dielectrophoretic fluid movement system to coat with a non-conducting fluid along a surface that includes a non-conducting surface to receive the non-conducting fluid and a first and second array of one or more substantially parallel microelectrodes positioned on the surface, said first array having microelectrode(s) positioned between, and alternating with, the microelectrode(s) of the second array, forming an interleaved pattern as well as an electric power source in communication with the first array and second array so that the first array and second array interact to create a non-uniform electric field such that the non-conducting fluid moves parallel to the microelectrodes in response to the applied non-uniform electric field.

Abstract: Rapid, size-based, deposition of particles from liquid suspension is accomplished using a nonuniform electric field created by coplanar microelectrode strips patterned on an insulating substrate. The scheme uses the dielectrophoretic force both to distribute aqueous liquid containing particles and, simultaneously, to separate the particles. Size-based separation is found within nanoliter droplets formed along the structure after voltage removal. Bioparticles or macromolecules of similar size can also be separated based on subtle differences in dielectric property, by controlling the frequency of the AC current supplied to the electrodes.

Abstract: Rapid, size-based, deposition of particles from liquid suspension is accomplished using a nonuniform electric field created by coplanar microelectrode strips patterned on an insulating substrate. The scheme uses the dielectrophoretic force both to distribute aqueous liquid containing particles and, simultaneously, to separate the particles. Size-based separation is found within nanoliter droplets formed along the structure after voltage removal. Bioparticles or macromolecules of similar size can also be separated based on subtle differences in dielectric property, by controlling the frequency of the AC current supplied to the electrodes.