Abstract: The present invention relates to compounds of formula (I). The compounds maybe used to antagonise the Stimulator of Interferon Genes (STING) protein and may thereby treat liver fibrosis, fatty liver disease, non-alcoholic steatohepatitis (NASH), pulmonary fibrosis, lupus, sepsis, rheumatoid arthritis (RA), type I diabetes, STING-associated vasculopathy with onset in infancy (SAVI), Aicardi-Goutieres syndrome (AGS), familial chilblain lupus (FCL), systemic lupus erythematosus (SLE), retinal vasculopathy, neuroinflammation, systemic inflammatory response syndrome, pancreatitis, cardiovascular disease, renal fibrosis, stroke and age-related macular degeneration (AMD).

Abstract: The present invention relates to compounds of formula (I). The compounds maybe used to modulate the Stimulator of Interferon Genes (STING) protein and thereby treat diseases such as cancer and microbial infections.

Abstract: The present invention relates to compounds of formula (I). The compounds may be used to modulate the acetyl coenzyme A synthetase short chain2 (ACSS2) protein and may thereby treat, ameliorate or prevent a disease selected from cancer, bacterial infection, viral infection, parasitic infection, fungal infection, neurodegenerative disease, neurological disorder, cerebrovascular disease, cardiovascular disease, non-alcoholic fatty liver disease and obesity. Alternatively, or additionally, the compounds may be used to promote healthy ageing.

Abstract: The present invention relates to compounds of formula (I). The compounds may be used to modulate the Stimulator of Interferon Genes (STING) protein and thereby treat diseases such as cancer and microbial infections.

Abstract: The present invention relates to compounds of formula (I). The compounds maybe used to modulate the Stimulator of Interferon Genes (STING) protein and thereby treat diseases such as cancer and microbial infections.

Abstract: The present invention relates to compounds of formula (I). The compounds may be used to modulate the Stimulator of Interferon Genes (STING) protein and thereby treat diseases such as cancer and microbial infections.

Abstract: A method for evaluating a patient in telehealth treatment includes receiving non-medical data corresponding to a patient from a social network service through a data network, identifying a health characteristic of the patient in the non-medical data, generating a message including health advice associated with the identified health characteristic of the patient, and sending the message to an electronic device associated with the patient through the data network.

Abstract: A method and apparatus for displaying locally stored content objects is disclosed. In one embodiment, the method comprises running an agent on a machine and integrating one or more locally stored objects in a page being displayed using information from the agent.

Abstract: A method and apparatus for displaying locally stored content objects is disclosed. In one embodiment, the method comprises receiving a message containing one or more parameters indicative of one or more characteristics of a client, and sending one of a plurality of groups of one or more content objects from a set of content objects to the client based on the one or more parameters, wherein each of the plurality of groups is suited for use with clients having a different set of one or more parameters.

Abstract: A method and apparatus for processing an overlay network infrastructure. In one embodiment, the method comprises a plurality of transparent access points (TAPs). Each TAP is communicably coupled between one or more clients and servers and a wide area network (WAN) to enable the one or more clients to communicate with the one or more servers, and is coupled to other of the TAPs via permanently, established secure links. The overlay network also comprises a controller coupled to each of the TAPs via a secure connection to configure the TAPs with information to enable each TAP to know what services are available and from which of the TAPs each of the services can be accessed.

Abstract: A method and apparatus for processing an overlay network infrastructure. In one embodiment, the method comprises a plurality of transparent access points (TAPs). Each TAP is communicably coupled between one or more clients and servers and a wide area network (WAN) to enable the one or more clients to communicate with the one or more servers, and is coupled to other of the TAPs via permanently, established secure links. The overlay network also comprises a controller coupled to each of the TAPs via a secure connection to configure the TAPs with information to enable each TAP to know what services are available and from which of the TAPs each of the services can be accessed.

Abstract: A method and apparatus for processing an overlay network infrastructure. In one embodiment, the method comprises a plurality of transparent access points (TAPs). Each TAP is communicably coupled between one or more clients and servers and a wide area network (WAN) to enable the one or more clients to communicate with the one or more servers, and is coupled to other of the TAPs via permanently, established secure links. The overlay network also comprises a controller coupled to each of the TAPs via a secure connection to configure the TAPs with information to enable each TAP to know what services are available and from which of the TAPs each of the services can be accessed.

Abstract: A method and apparatus for displaying locally stored content objects is disclosed. In one embodiment, the method comprises receiving a message containing one or more parameters indicative of one or more characteristics of a client, and sending one of a plurality of groups of one or more content objects from a set of content objects to the client based on the one or more parameters, wherein each of the plurality of groups is suited for use with clients having a different set of one or more parameters.

Abstract: A method and apparatus for displaying locally stored content objects is disclosed. In one embodiment, the method comprises receiving a message containing one or more parameters indicative of one or more characteristics of a client, and sending one of a plurality of groups of one or more content objects from a set of content objects to the client based on the one or more parameters, wherein each of the plurality of groups is suited for use with clients having a different set of one or more parameters.

Abstract: A method and apparatus for processing an overlay network infrastructure. In one embodiment, the method comprises a plurality of transparent access points (TAPs). Each TAP is communicably coupled between one or more clients and servers and a wide area network (WAN) to enable the one or more clients to communicate with the one or more servers, and is coupled to other of the TAPs via permanently, established secure links. The overlay network also comprises a controller coupled to each of the TAPs via a secure connection to configure the TAPs with information to enable each TAP to know what services are available and from which of the TAPs each of the services can be accessed.

Abstract: A method and apparatus for displaying locally stored content objects is disclosed. In one embodiment, the method comprises receiving a message containing one or more parameters indicative of one or more characteristics of a client, and sending one of a plurality of groups of one or more content objects from a set of content objects to the client based on the one or more parameters, wherein each of the plurality of groups is suited for use with clients having a different set of one or more parameters.

Abstract: A method and apparatus for providing to a user personalized information from an database comprising contributor content records and contributor profile records, based upon a comparison of the user's search query and user profile record with the contributor content records and contributor profile records. The database may contain other content records from which personalized information may be obtained. Contributors may provide additional contributor content records to the database, in exchange for valuable consideration.

Abstract: A method and apparatus for providing to a user personalized information from an database comprising contributor content records and contributor profile records, based upon a comparison of the user's search query and user profile record with the contributor content records and contributor profile records. The database may contain other content records from which personalized information may be obtained. Contributors may provide additional contributor content records to the database, in exchange for valuable consideration.

Abstract: A method and apparatus for providing to a user personalized information from an database comprising contributor content records and contributor profile records, based upon a comparison of the user's search query and user profile record with the contributor content records and contributor profile records. The database may contain other content records from which personalized information may be obtained. Contributors may provide additional contributor content records to the database, in exchange for valuable consideration.