Abstract: A method of dynamic masking of variably selected portions of the media content based upon real-time audience composition is provided. The method includes the steps of identifying one or more members of an audience for playback of media content. Upon identifying one or more audience members, retrieving corresponding preselected preferences for media playback. Generating a media masking instruction according to the preselected preferences, and outputting to a user device a masked media content correlating to the instruction. The invention additionally relates to a system that implements such a method.

Abstract: A method and an electronic monitoring system are provided. The electronic monitoring system includes a button having an actuatable actuator and an identity. The button is configured to encrypt a data packet corresponding to the identity of the button and broadcast the encrypted data packet over a wireless Personal Area Network (PAN), either periodically or in response to actuation of the actuatable actuator. The encrypted data packet is received with one of a plurality of user devices having a corresponding software application running thereon and is re-transmitted, along with a location of the user device, by the user device which received the encrypted data packet to a cloud-based control service. In response to the data packet received, the cloud-based control system either stores the location of the user device for future reference or generates an action in response thereto.

Abstract: Disclosed are pyrazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein A, X, Z, m, p, and R2 are as described herein. In certain embodiments, a compound disclosed herein inhibits the activity of one or more members of the TGF-? superfamily, and can be used to treat disease by blocking such activity.

Abstract: Exemplary system, method and computer-accessible medium for determining a characteristic(s) of a tissue(s), can be provided which can include, for example, ablating the tissue(s), illuminating the tissue(s) during the ablation procedure; and continuously determining the characteristic(s) based on the ablation and illumination procedures. The tissue(s) can be ablated using radiofrequency ablation. The illumination procedure can be performed with a radiation in a visible spectrum.

Abstract: An exemplary system, method and computer-accessible medium for determining particular for a portion(s) of an organ of a patient(s) can be provided, which can include, for example, receiving an in vivo optical coherence tomography (OCT) imaging information for the portion(s), and determining (i) a lesion formation on or in the portion(s), (ii) a contact of a catheter on or with the portion(s), or (iii) an angle of the catheter with respect to the portion(s), by applying a convolutional neural network(s) to the in vivo OCT imaging information.

Abstract: A method of treating focal segmental glomerulosclerosis with a compound of Formula I is provided. FSGS may be primary (no known cause) or secondary. The secondary FSGS may be associated with infections or viruses such as HIV, diseases such as sickle cell disease or lupus, toxins or drugs such as anabolic steroids, heroin or pamidronate, nephron loss and hyperfiltration, such as with chronic pyelonephritis and reflux, morbid obesity, or diabetes mellitus.

Abstract: A method of updating of firmware to a client device such as a BLE button is provided. The method includes the steps of providing a first user device and detecting the client device with the first user device. It is determined if the client device is in an update mode in response to instructions from a second user device. The firmware is uploaded from the first user device to the client device in response to the client device being in the update mode.

Abstract: An electronic monitoring system and a method of monitoring an activity zone are provided. A monitor monitors for an activity within an activity zone. The monitor is configured to generate a data packet corresponding to the activity. The data packet is transmitted to a control system that may be cloud-based, and the data packet is stored in computer-readable memory associated with the control system. The data packet is encrypted utilizing a public key prior to storage in computer-readable memory. The encrypted data packet may be decrypted on a user device using a private key.

Abstract: Disclosed herein are compounds of Formula (I), intermediates thereof, and methods for making the same: Also described herein are the use of such compounds and compositions for the treatment of diseases and disorders that are mediated, at least in part, by one or more cyclins, including cancer.

Abstract: An electronic monitoring system has one or more imaging devices that can detect a triggering event based on motion and/or sound and that concurrently provide a push notification to a user device with a custom audio alert indicative of the one or more triggering events for quickly identifying the triggering without requiring the remote device to execute a dedicated application program. The custom audio alert portion of the push notification may provide various details of the triggering event, categorized as either a genus level triggering event and/or a species level triggering event, i.e., a subset of the genus level triggering event. The push notification can operate as a custom audio alert and a pop-up message which can be pushed to the device and broadcast or displayed via an operating system of the device.

Abstract: Activators of Kv3.1 and/or Kv3.2 channels which are therapeutically useful in the treatment of cognitive dysfunction and the negative symptoms which are associated with central nervous system disorders such as schizophrenia, Alzheimer's disease, Tourette's syndrome, autism, dementia, epilepsy and other disorders where gamma oscillations are dysfunctional are provided. The activators include substituted N-heteroaryl compounds.

Abstract: Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.

Abstract: The present application relates generally to compounds useful for the treatment and/or enhancement of cognitive dysfunction and negative symptoms associated with CNS disorders where the circuitry involving fast spiking PV+ interneurons and the production of cortical gamma oscillations is disrupted. The subject disclosure enables the manufacture of medicaments as well as compositions containing same for use in methods of therapy and prophylaxis of cognitive dysfunction and negative symptoms.

Abstract: A system for imaging material, typically in an underground scenario, comprising of a plurality of conductive electrodes supported on a conductive substrate positionable in an environment to be imaged, a signal generator connected to at least two of the electrodes, and a signal detector connected to at least two of the electrodes, and wherein an impedance compensator is arranged between each electrode and its substrate to counter parasitic impedance between the two. Typically the impedance compensator may be arranged to act as a negative capacitance, which may be approximately equal to any capacitance between the electrode and the substrate. An electrode may be a drive electrode coupled to a signal generator, or a detector electrode coupled to a detector, or may be reconfigurable to act as either one.

Abstract: A method and system are provided for securely onboarding a Bluetooth Low Energy peripheral device or other peripheral device operating over a personal area network (PAN) onto a cloud-based network system. The method includes providing a private-public key pair, wherein the private key is stored on the peripheral device and the public key is stored on a database within the cloud-based network system. Upon user activation, the peripheral device begins advertising, using a PAN communications protocol, a first hash value generated with the private key, which is received at the cloud-based processor and verified with the corresponding public key. In response to verifying the first hash value, the cloud-based processor transmits a public key encrypted random code, which is received at the peripheral device and decrypted with the private key.

Abstract: An exemplary catheter can be provided, which can include, for example a source fiber(s) configured to (i) receive a near infrared spectroscopic (NIRS) radiation, and (ii) provide the NIRS radiation to a portion(s) of a sample(s), a detection fiber(s) configured to receive a return radiation from the sample(s) that can be based on the NIRS radiation that was provided to the portion(s) of the sample(s), and an ablation electrode(s) configured to ablate the sample(s) based on the return radiation. The source fiber(s), the detection fiber(s), and the ablation electrode(s) can be integrated into the single sheath. The ablation electrode(s) can be a radiofrequency ablation electrode.

Abstract: Nucleic acid and polypeptide sequences for predicting and controlling shell phenotype in palm.

Abstract: The present invention relates to compounds useful in the modulation of ion channel activity in cells. The invention also relates to use of these compounds in the treatment of pain, and pharmaceutical compositions containing these compounds and methods for their preparation.

Abstract: A method of updating of firmware to a client device such as a BLE button is provided. The method includes the steps of providing a first user device and detecting the client device with the first user device. It is determined if the client device is in an update mode in response to instructions from a second user device. The firmware is uploaded from the first user device to the client device in response to the client device being in the update mode.

Abstract: Disclosed are novel benzazole compounds and compositions comprising the compounds. The compounds are useful as kinase inhibitors including interleukin receptor associated kinases (IRAK) inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.