Patents by Inventor Rajinder Singh

Rajinder Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Triazole derivatives useful as Axl inhibitors
    Patent number: 8389557
    Abstract: Methods of using triazole derivatives in treating diseases or conditions associated with Axl catalytic activity are disclosed.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: March 5, 2013
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Catherine Sylvain, Sacha Holland, Jing Zhang, John J. Partridge, Jeffrey Clough, Ankush Argade
  • Small molecule inhibitors of spleen tyrosine kinase (SYK)
    Patent number: 8377945
    Abstract: This disclosure concerns compounds which are useful as inhibitors of spleen tyrosine kinase (Syk) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of Syk. This disclosure also relates to pharmaceutical compositions containing these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: February 19, 2013
    Assignee: Rigel Pharmaceuticals Inc.
    Inventors: Jing Zhang, Rajinder Singh, Dane Goff, Taisei Kinoshita
  • Protein kinase C inhibitors and uses thereof
    Patent number: 8377924
    Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: February 19, 2013
    Assignee: Rigel Pharmaceuticals Inc.
    Inventors: Rajinder Singh, Huí Li, Haoran Zhao, Rao Kolluri, Kin Tso, John Ramphal, Shihai Gu, Carlos Valdez, Jing Zhang, Emily Stauffer, Matthew Duncton, Salvador Alvarez
  • EVAPORATIVE STRUCTURES, PARTICULARLY FOR BODY COOLING
    Publication number: 20130025315
    Abstract: A generally planar, conformable evaporative structure, particularly for incorporation in a garment or an item of personal protective equipment as part of a system to cool the wearer's body, includes an envelope of substantially impermeable, flexible material containing: a layer of flexible wick material disposed adjacent to a major face of the envelope and adapted to hold a working fluid in liquid phase for evaporation by heat conducted through the envelope; a layer of flexible, breathable fabric in parallel with the layer of wick material; and an array of flexible ribs such as open helical coils within the layer of breathable fabric adapted to maintain pathways for the flow of working fluid in vapour phase towards a condensation zone.
    Type: Application
    Filed: April 19, 2011
    Publication date: January 31, 2013
    Applicant: QINETIQ LIMITED
    Inventors: Robert Anthony Freeman, Rajinder Singh
  • Carboxamide compounds and methods for using the same
    Patent number: 8362235
    Abstract: Disclosed are carboxamide compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R1, R2, R3, R4, T, p, q, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: January 29, 2013
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Ihab S. Darwish, Hui Hong, Rajinder Singh, Xiang Xu
  • Carboxamide Compounds and Methods for Using the Same
    Publication number: 20130023660
    Abstract: Disclosed are carboxamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R1, R2, R3, R4, D, J, Z, T, p, q, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.
    Type: Application
    Filed: September 18, 2012
    Publication date: January 24, 2013
    Applicant: RIGEL PHARMACEUTICALS, INC.
    Inventors: Jiaxin Yu, Hui Hong, Ihab S. Darwish, Xiang Xu, Rajinder Singh
  • PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES
    Publication number: 20130018041
    Abstract: This invention is directed to compounds of formula (I): where n, m, Y, R1, R2, R3, R4 and R5 are disclosed herein, as isolated stereoisomers or mixtures thereof, or pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising the compounds of formula (I); and methods of using the compounds and the pharmaceutical compositions in treating diseases or conditions associated with JAK2 activity.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 17, 2013
    Applicant: Rigel Pharmaceutical, Inc.
    Inventors: Somasekhar Bhamidipati, Jeffrey Clough, Ankush Argade, Rajinder Singh, Vadim Markovtosov, Pingyu Ding, Jiaxin Yu, Andy Atuegbu, Hui Hong, Ihab Darwish, Sambaiah Thota
  • BRIDGED BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS
    Publication number: 20130018051
    Abstract: Bridged bicyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 17, 2013
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Sacha Holland, Joane Litvak, Dane Goff, Jing Zhang, Thilo J. Heckrodt
  • PYRIMIDINEDIAMINE KINASE INHIBITORS
    Publication number: 20130012501
    Abstract: Disclosed embodiments provide pyrimidinediamine compounds useful for inhibiting kinase activity, including the activity of polo-like kinase 1 (PLK1). Also disclosed are pharmaceutical compositions comprising these compounds and methods of treating diseases associated with kinase activity, in particular enhanced PLK1 catalytic activity, such as diseases associated with abnormal cell proliferation, including neoplastic disorders.
    Type: Application
    Filed: September 11, 2012
    Publication date: January 10, 2013
    Inventors: Rajinder Singh, Andy Atuegbu, John Ramphal, Hui Li, Marina Gelman, Jeffrey Clough, Carlos Valdez, Somasekhar Bhamidipati, Sambaiah Thota, Darren McMurtrie
  • Polycyclic heteroaryl substituted triazoles useful as Axl inhibitors
    Patent number: 8349838
    Abstract: Polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: January 8, 2013
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Thilo J. Heckrodt, Sacha Holland
  • Radio frequency identification transceiver
    Patent number: 8351490
    Abstract: A radio frequency identification transceiver is disclosed. The radio frequency identification transceiver includes: a transmitter path, including; a pulse shaper to tunably shape the pulse of a signal to be transmitted in different predefined frequency ranges; a modulator to modulate the shaped pulse to be transmitted into one of a plurality of predefined frequency ranges; a receiver path, including: a demodulator to demodulate a received signal from a plurality of predefined frequency ranges.
    Type: Grant
    Filed: January 28, 2008
    Date of Patent: January 8, 2013
    Assignee: Agency for Science, Technology and Research
    Inventors: Xuesong Chen, Pradeep B. Khannur, Wooi Gan Yeoh, Rajinder Singh
  • Compositions and methods for inhibition of the JAK pathway
    Patent number: 8343954
    Abstract: Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful. Also disclosed are methods of making the compounds.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: January 1, 2013
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Hui Li, Thilo J. Heckrodt, Yan Chen, Darren John McMurtrie, Vanessa Taylor, Rajinder Singh, Pingyu Ding, Rose Yen
  • 2,4-pyrimidinediamine compounds and their uses
    Patent number: 8334296
    Abstract: The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
    Type: Grant
    Filed: November 18, 2008
    Date of Patent: December 18, 2012
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Ankush Argade, Donald G Payan, Susan Molineaux, Sasha J Holland, Jeffrey Clough, Holger Keim, Somasekhar Bhamidipati, Catherine Sylvain, Hui Li, Alexander B Rossi
  • 2,4-pyrimidinediamine compounds for treatment of inflammatory disorders
    Patent number: 8334297
    Abstract: 2,4-Pyrimidinediamine compounds represented by formula (I), methods for preparing the same and methods for treating an inflammatory disorder and for inhibiting the production of IL-23 and/or stimulating the production of IL-10 using the same:
    Type: Grant
    Filed: January 13, 2010
    Date of Patent: December 18, 2012
    Assignee: Rigel Pharmaceuticals Inc.
    Inventors: Hui Li, Esteban Masuda, Stephanie Yung, Taisei Kinoshita, Rongxian Ding, Rajinder Singh, Tarikere Gururaja, Donald G. Payan, Kin Tso
  • Compositions and methods for inhibition of the JAK pathway
    Patent number: 8324200
    Abstract: Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: December 4, 2012
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Hui Li, Thilo J. Heckrodt, Yan Chen, Darren John McMurtrie, Vanessa Taylor, Rajinder Singh, Pingyu Ding, Sambaiah Thota, Rose Yen
  • COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY
    Publication number: 20120301486
    Abstract: The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
    Type: Application
    Filed: August 7, 2012
    Publication date: November 29, 2012
    Inventors: Somasekhar Bhamidipati, Hui Li, Rajinder Singh, Vanessa Taylor, Jeffrey Clough, Darren McMurtrie
  • Carboxamide compounds and methods for using the same
    Patent number: 8314107
    Abstract: Disclosed are carboxamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R1, R2, R3, R4, D, J, Z, T, p, q, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: November 20, 2012
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Jiaxin Yu, Hui Hong, Ihab S. Darwish, Xiang Xu, Rajinder Singh
  • 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases
    Patent number: 8314093
    Abstract: The present invention provides 3-hydroxyphenyl-2,4-pyrimidinediamine compounds of formula I, as well as related compositions and methods for treating a variety of autoimmune diseases.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: November 20, 2012
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Jeffrey Wayne Clough, Somasekhar Bhamidipati, Rajinder Singh, Esteban Masuda, Haoran Zhao
  • Pyrimidine-2-amine compounds and their use as inhibitors of JAK kinases
    Patent number: 8309566
    Abstract: This invention is directed to compounds of formula (I): where n, m, Y, R1, R2, R3, R4 and R5 are disclosed herein, as isolated stereoisomers or mixtures thereof, or as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising the compounds of formula (I); and methods of using the compounds and the pharmaceutical compositions in treating diseases or conditions associated with JAK2 activity.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: November 13, 2012
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Somasekhar Bhamidipati, Jeffrey Clough, Ankush Argade, Rajinder Singh, Vadim Markovtosov, Pingyu Ding, Jiaxin Yu, Andy Atuegbu, Hui Hong, Ihab Darwish, Sambaiah Thota
  • SYSTEM AND METHOD FOR SECURE COMMUNICATION FOR CASHLESS TRANSACTIONS
    Publication number: 20120284193
    Abstract: Embodiments of the present invention provide a system and method for an access point providing client to point-of-sale communication over a network, comprising: receiving credentials from the point-of-sale; sending at least one beacon message; receiving a probe request from a client; sending a probe response to the client; authenticating a connection with the client: exchanging capabilities with the client; performing a security handshake with the client; assigning at least one dynamic IP address to the client; and establishing an https session between the client and the point-of-sale over the network.
    Type: Application
    Filed: May 2, 2011
    Publication date: November 8, 2012
    Inventors: Vaduvur Bharghavan, Jari Malinen, Rajinder Singh, Jason Fieldman, Rachna Ahlawat, Kannan Konath, Sandeep Gilotra