Patents by Inventor Rajinder Singh

Rajinder Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TGF-ß INHIBITORS
    Publication number: 20210130361
    Abstract: Disclosed are pyrazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein A, X, Z, m, p, and R2 are as described herein. In certain embodiments, a compound disclosed herein inhibits the activity of one or more members of the TGF-? superfamily, and can be used to treat disease by blocking such activity.
    Type: Application
    Filed: November 2, 2020
    Publication date: May 6, 2021
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Marina Gelman, Todd Kinsella, Somasekhar Bhamidipati, Ihab Darwish, Rajinder Singh, Jiaxin Yu
  • Modulators of chemokine receptors
    Patent number: 10988464
    Abstract: Compounds are provided as chemokine inhibitors having the structure:
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: April 27, 2021
    Assignee: ChemoCentryx, Inc.
    Inventors: Xi Chen, Dean R. Dragoli, Junfa Fan, Jaroslaw Kalisiak, Antoni Krasinski, Manmohan Reddy Leleti, Venkat Mali, Jeffrey McMahon, Rajinder Singh, Hiroko Tanaka, Ju Yang, Chao Yu, Penglie Zhang
  • MADS-BOX DOMAIN ALLELES FOR CONTROLLING SHELL PHENOTYPE IN PALM
    Publication number: 20210105961
    Abstract: Nucleic acid and polypeptide sequences for predicting and controlling shell phenotype in palm.
    Type: Application
    Filed: December 22, 2020
    Publication date: April 15, 2021
    Inventors: Rajinder Singh, Leslie Low Eng Ti, Leslie Ooi Cheng Li, Meilina Ong Abdullah, Rajanaidu Nookiah, Ravigadevi Sambanthamurthi, Andrew Van Brunt, Muhammad A. Budiman, Steven W. Smith, Nathan D. Lakey, Rob Martienssen, Jared Ordway
  • Method of treating focal segmental glomerulosclerosis
    Patent number: 10973809
    Abstract: A method of treating focal segmental glomerulosclerosis with a compound of Formula I is provided. FSGS may be primary (no known cause) or secondary. The secondary FSGS may be associated with infections or viruses such as HIV, diseases such as sickle cell disease or lupus, toxins or drugs such as anabolic steroids, heroin or pamidronate, nephron loss and hyperfiltration, such as with chronic pyelonephritis and reflux, morbid obesity, or diabetes mellitus.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: April 13, 2021
    Assignee: ChemoCentryx, Inc.
    Inventors: Zhenhua Miao, Thomas Schall, Rajinder Singh
  • 2-OXINDOLE COMPOUNDS
    Publication number: 20210101890
    Abstract: Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.
    Type: Application
    Filed: July 17, 2020
    Publication date: April 8, 2021
    Inventors: Xi CHEN, Dean R. DRAGOLI, Pingchen FAN, Manmohan Reddy LELETI, Rebecca M. LUI, Viengkham MALATHONG, Jay P. POWERS, Rajinder SINGH, Hiroko TANAKA, Ju YANG, Chao YU, Penglie ZHANG
  • Method for measuring and controlling methanol concentration in a methanol fuel cell
    Patent number: 10957928
    Abstract: Methods for measuring and controlling the methanol concentration in a methanol fuel cell such as a direct methanol fuel cell or fuel cell stack are disclosed. Processors and memory storage containing programs which execute instructions to control the methanol concentration in the fuel cell or fuel cell stack are also disclosed.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: March 23, 2021
    Assignee: Oorja Corporation
    Inventors: Md Opu, Rajinder Singh, Jeff Henderson, Aditya Koparkar
  • Nrf2 Activating Compounds and Uses Thereof
    Publication number: 20210078969
    Abstract: Aspects of the present disclosure include compounds that activate Nrf2. Such compounds find use in the treatment of autoimmune and inflammatory diseases and disorders, such as for example psoriasis and multiple sclerosis. Embodiments of the present disclosure also relate to pharmaceutical compositions that include these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: October 20, 2020
    Publication date: March 18, 2021
    Inventors: Matthew Duncton, Rajinder Singh
  • Amide compounds and method for making and using
    Patent number: 10947216
    Abstract: Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: March 16, 2021
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Kin Tso, Hui Li, Yan Chen, Rose Yen, Vanessa Taylor, Thilo Heckrodt, Rajinder Singh, Simon Shaw
  • Nrf2 activating compounds and uses thereof
    Patent number: 10941135
    Abstract: Aspects of the present disclosure include compounds that activate Nrf2. Such compounds may find use in the treatment of autoimmune and inflammatory diseases and disorders, such as for example psoriasis and multiple sclerosis. Embodiments of the present disclosure also relate to pharmaceutical compositions that include these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: April 2, 2020
    Date of Patent: March 9, 2021
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Matthew Duncton, Rajinder Singh
  • IRAK inhibitors and method for making and using
    Patent number: 10941140
    Abstract: Disclosed embodiments concern interleukin receptor associated kinases (IRAK) inhibitors, such as oxazole compounds, and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: March 9, 2021
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Hui Li, Thilo Heckrodt, Yan Chen, Ryan Kelley, Darren McMurtrie, Kin Tso, Vanessa Taylor, Rajinder Singh, Rose Yen, Jack Maung
  • AMPK-activating heterocyclic compounds and methods for using the same
    Patent number: 10941134
    Abstract: Disclosed are substituted pyridine compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure wherein E, J, T, the ring system denoted by “B”, T, R3, R4, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: March 9, 2021
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Dane Goff, Donald Payan, Rajinder Singh, Simon Shaw, David Carroll, Yasumichi Hitoshi
  • IMMUNOMODULATOR COMPOUNDS
    Publication number: 20210052514
    Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (II): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: January 23, 2020
    Publication date: February 25, 2021
    Inventors: Christopher LANGE, Viengkham MALATHONG, Darren J. McMURTRIE, Sreenivas PUNNA, Rajinder SINGH, Ju YANG, Penglie ZHANG
  • PRODRUGS OF FUSED-BICYCLIC C5aR ANTAGONISTS
    Publication number: 20210052612
    Abstract: The present disclosure provides, inter alia, Compounds of Formulae IA, IB, IC, IIA, IIB and IIC or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.
    Type: Application
    Filed: April 1, 2019
    Publication date: February 25, 2021
    Inventors: Pingchen FAN, Rebecca M. LUI, Rajinder SINGH, Venkat Reddy MALI, Yibin ZENG, Penglie ZHANG
  • Immunomodulator compounds
    Patent number: 10919852
    Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein Z, L, R1a, R1b, R1c, R1d, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: February 16, 2021
    Assignee: ChemoCentryx, Inc.
    Inventors: Christopher Lange, Viengkham Malathong, Venkat Reddy Mali, Jeffrey McMahon, Darren J. McMurtrie, Sreenivas Punna, Howard S. Roth, Rajinder Singh, Yu Wang, Ju Yang, Penglie Zhang
  • MADS-box domain alleles for controlling SHELL phenotype in palm
    Patent number: 10905061
    Abstract: Nucleic acid and polypeptide sequences for predicting and controlling shell phenotype in palm.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: February 2, 2021
    Assignee: Malaysian Palm Oil Board
    Inventors: Rajinder Singh, Leslie Low Eng Ti, Leslie Ooi Cheng Li, Meilina Ong Abdullah, Rajanaidu Nookiah, Ravigadevi Sambanthamurthi, Andrew Van Brunt, Muhammad A. Budiman, Steven W. Smith, Nathan D. Lakey, Rob Martienssen, Jared Ordway
  • INDANES AS PD-L1 INHIBITORS
    Publication number: 20210008049
    Abstract: Compounds represented by Formula (I) or (II): are provided herein, or a pharmaceutically acceptable salt, or a prodrug or bioisostere thereof; wherein R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, R2a?, R2b?, R2c?, R3?, R4?, R5?, R6a?, Y, Y?, and the subscripts m and n are as defined herein.
    Type: Application
    Filed: July 9, 2020
    Publication date: January 14, 2021
    Inventors: Viengkham MALATHONG, Venkat Reddy MALI, Darren J. McMURTRIE, Sreenivas PUNNA, Howard S. ROTH, Rajinder SINGH, Ju YANG, Penglie ZHANG
  • DIARYL SUBSTITUTED 5,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS
    Publication number: 20210009596
    Abstract: The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.
    Type: Application
    Filed: July 27, 2020
    Publication date: January 14, 2021
    Inventors: Pingchen FAN, Christopher W. LANGE, Rebecca M. LUI, Viengkham MALATHONG, Venkat Reddy MALI, Sreenivas PUNNA, Rajinder SINGH, Yibin ZENG, Penglie ZHANG
  • TREATMENT OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS WITH CCR2 ANTAGONISTS
    Publication number: 20210000834
    Abstract: Provided herein are methods of treating focal segmental glomerulosclerosis, said methods include administering to a subject in need thereof a therapeutically effective amount of a CCR2 antagonist. In some embodiments, the CCR2 antagonist is used in monotherapy. In some embodiments, the CCR2 antagonist is used in combination therapy. In some embodiments, the additional therapeutic agent is a RAAS blocker and/or an endothelin receptor inhibitor.
    Type: Application
    Filed: August 11, 2020
    Publication date: January 7, 2021
    Inventors: Zhenhua MIAO, Thomas J. SCHALL, Rajinder SINGH
  • COMPOUNDS FOR TREATMENT OF PD-L1 DISEASES
    Publication number: 20210002229
    Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R3a, R4, R5, R6, R7, R8 and the subscript n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: June 19, 2020
    Publication date: January 7, 2021
    Inventors: Viengkham MALATHONG, Pingchen FAN, Christopher LANGE, Venkat Reddy MALI, Darren J. McMURTRIE, Sreenivas PUNNA, Howard S. ROTH, Rajinder SINGH, Ju YANG, Penglie ZHANG
  • GENE CONTROLLING SHELL PHENOTYPE IN PALM
    Publication number: 20200399717
    Abstract: Nucleic acid sequences for predicting and controlling shell phenotype in palm.
    Type: Application
    Filed: March 24, 2020
    Publication date: December 24, 2020
    Inventors: Rajinder SINGH, Leslie Low Eng TI, Leslie Ooi Cheng LI, Meilina Ong ABDULLAH, Rajanaidu NOOKIAH, Ravigadevi SAMBANTHAMURTHI, Steven W. SMITH, Nathan D. LAKEY, Rob MARTIENSSEN, Jared ORDWAY, Michael HOGAN