Patents by Inventor Rajindra Aneja

Rajindra Aneja has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110040108
    Abstract: Embodiments of the invention relate to natural and synthetic inositolphospholipid (IPL) materials, their preparation and applications. They provide compositions of the parent IPL comprising phosphatidylinositol (PI), PI-phosphates (phosphoinositides) and derivatives and analogues, and a process for their production starting from natural IPL. The embodiments further provide functional derivatives of PI for biomedical applications including a platform for drug design and delivery to therapeutic targets in the phosphoinositide mediated cellular signaling and allied cascades. The embodiments pertain to IPL having absolute stereo-structure. The embodiments further pertain to unique IPL and PI product compositions for defined applications, particularly pharmaceutical compositions for prophylaxis and treatment of diseases related to aberrant cellular and nuclear signaling mediated by PI and PI derived phosphates, and associated phosphoinositide specific enzymes including PI-PLC and PI 3-kinase.
    Type: Application
    Filed: October 26, 2010
    Publication date: February 17, 2011
    Applicant: Nutrimed Bioetech
    Inventor: Rajindra Aneja
  • Patent number: 7368129
    Abstract: Disclosed is a new structural class of amphiphilic molecules which incorporate a hydrophilic material or polymer attached, at spatially distinct sites, to at least two hydrophobic residues. Certain of the amphiphilic molecules comprise a plurality of hydrophobic moieties. All such amphiphilic molecules have a common structural motif and, in contact with water, display surface activity and self-assemble into multimolecular aggregates and liquid crystalline phases. Also disclosed are enhanced stability liposomes that incorporate such amphiphilic molecules via unique interactions, and methods of using such formulations in a variety of applications including drug delivery, nutrition, bio-diagnostics, cosmetics, blood products and related applications.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: May 6, 2008
    Assignee: Nutrimed Biotech
    Inventor: Rajindra Aneja
  • Publication number: 20070142653
    Abstract: Embodiments of the invention relate to natural and synthetic inositolphospholipid (IPL) materials, their preparation and applications. They provide compositions of the parent IPL comprising phosphatidylinositol (PI), PI-phosphates (phosphoinositides) and derivatives and analogues, and a process for their production starting from natural IPL. The embodiments further provide functional derivatives of PI for biomedical applications including a platform for drug design and delivery to therapeutic targets in the phosphoinositide mediated cellular signaling and allied cascades. The embodiments pertain to IPL having absolute stereo-structure. The embodiments further pertain to unique IPL and PI product compositions for defined applications, particularly pharmaceutical compositions for prophylaxis and treatment of diseases related to aberrant cellular and nuclear signaling mediated by PI and PI derived phosphates, and associated phosphoinositide specific enzymes including PI-PLC and PI 3-kinase.
    Type: Application
    Filed: December 20, 2006
    Publication date: June 21, 2007
    Applicant: NUTRIMED BIOTECH
    Inventor: Rajindra Aneja
  • Patent number: 7037486
    Abstract: The present invention provides novel compounds comprising cellular phosphoinositides and analogues tagged with stable or radioactive isotopes. The present invention also provides novel methods for the preparation of the said phosphoinositides by syntheses, and novel key intermediates of synthesis; the novel methods of synthesis are applied also for the preparation of the phosphoinositides in non-labelled form. In addition, the present invention discloses a class of novel compounds as isotope labelled key precursors of labelled phosphoinositides. These precursors are derivatives of the target phosphoinositides, labelled with stable or radioactive isotopes, wherein OH and phosphate groups are blocked with temporary protecting groups.
    Type: Grant
    Filed: January 24, 2002
    Date of Patent: May 2, 2006
    Assignee: Nutrimed Biotech
    Inventor: Rajindra Aneja
  • Patent number: 6737536
    Abstract: This invention relates to inositolphospholipids, particularly to synthetic phosphatidyl-myo-inositols (PtdIns), ceramide-phosphoinositols (CerPhosIns) and their structural and stereochemical analogues. The invention specifically provides a novel approach to synthesis of inositolphospholipids which is suitable for laboratory scale preparation as well as for large scale industrial production. The synthetic approach is applicable equally well for the preparation of inositolphospholipids carrying saturated lipid chains, unsaturated lipid chains with one or more double or triple bonds, chains with hydroxyl, amino and other functional groups, or combinations of these. In addition, it provides novel high purity diastereomer molecular species of inositolphospholipids that have unequivocally defined structure and absolute stereochemistry in both the myo-inositol and the glycerol residues and are obtainable only by the present new approach.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: May 18, 2004
    Assignee: Nutrimed Biotech
    Inventor: Rajindra Aneja
  • Patent number: 6699499
    Abstract: Disclosed is a new structural class of amphiphilic molecules which incorporate a hydrophilic material or polymer attached, at spatially distinct sites, to at least two hydrophobic residues. Certain of the amphiphilic molecules comprise a plurality of hydrophobic moieties. All such amphiphilic molecules have a common structural motif and, in contact with water, display surface activity and self-assemble into multimolecular aggregates and liquid crystalline phases. Also disclosed are enhanced stability liposomes that incorporate such amphiphilic molecules via unique interactions, and methods of using such formulations in a variety of applications including drug delivery, nutrition, bio-diagnostics, cosmetics, blood products and related applications.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: March 2, 2004
    Assignee: Nutrimed Biotech
    Inventor: Rajindra Aneja
  • Patent number: 6384260
    Abstract: This invention provides analogues of phosphatidylinositol-phosphates modified at one or more selected inositol-hydroxyls and optionally carrying reporter or anchoring groups attached in the lipid or the inositol residues, and, the synthetic intermediates and methods for the preparation of these analogues. The analogues are useful as research reagents in biomedical studies related to structure, function and therapeuticals, including reference materials for analyzing the metabolic products in safety and efficacy studies of 2- and/or 3-hydroxyl modified inositols and phosphatidylinositols as drug candidates.
    Type: Grant
    Filed: April 3, 2001
    Date of Patent: May 7, 2002
    Assignee: Nutrimed Biotech
    Inventor: Rajindra Aneja
  • Patent number: 6376697
    Abstract: The present invention provides novel compounds comprising cellular phosphoinositides and analogues tagged with stable or radioactive isotopes. The present invention also provides novel methods for the preparation of the said phosphoinositides by syntheses, and novel key intermediates of synthesis; the novel methods of synthesis are applied also for the preparation of the phosphoinositides in non-labelled form. In addition, the present invention discloses a class of novel compounds as isotope labelled key precursors of labelled phosphoinositides. These precursors are derivatives of the target phosphoinositides, labelled with stable or radioactive isotopes, wherein OH and phosphate groups are blocked with temporary protecting groups.
    Type: Grant
    Filed: April 15, 1999
    Date of Patent: April 23, 2002
    Assignee: Nutrimed Biotech
    Inventor: Rajindra Aneja
  • Patent number: 6284267
    Abstract: Disclosed is a new structural class of amphiphilic molecules which incorporate a hydrophilic material or polymer attached, at spatially distinct sites, to at least two hydrophobic residues. Certain of the amphiphilic molecules comprise a plurality of hydrophobic moieties. All such amphiphilic molecules have a common structural motif and, in contact with water, display surface activity and self-assemble into multimolecular aggregates and liquid crystalline phases. Also disclosed are enhanced stability liposomes that incorporate such amphiphilic molecules via unique interactions, and methods of using such formulations in a variety of applications including drug delivery, nutrition, bio-diagnostics, cosmetics, blood products and related applications.
    Type: Grant
    Filed: August 13, 1997
    Date of Patent: September 4, 2001
    Assignee: Nutrimed Biotech
    Inventor: Rajindra Aneja
  • Patent number: 6232486
    Abstract: This invention provides analogues of phosphatidylinositol-phosphates modified at one or more selected inositol-hydroxyls and optionally carrying reporter or anchoring groups attached in the lipid or the inositol residues, and, the synthetic intermediates and methods for the preparation of these analogues. The analogues are useful as research reagents in biomedical studies related to structure, function and therapeuticals, including reference materials for analyzing the metabolic products in safety and efficacy studies of 2- and/or 3-hydroxyl modified inositols and phosphatidylinositols as drug candidates.
    Type: Grant
    Filed: June 10, 1997
    Date of Patent: May 15, 2001
    Assignee: Nutrimed Biotech
    Inventor: Rajindra Aneja
  • Patent number: 6096916
    Abstract: Disclosed are unique starting materials, reaction sequences and intermediate compounds for the preparation of D-3-phosphorylated phosphoinositides (3-PPI) of unambiguous structure and absolute stereochemistry. The enantiomerically pure D-3-phosphorylated phosphoinositides also provided have many uses, including in the development of diagnostics and therapeutics based on the roles of 3-PPI in intracellular signaling.
    Type: Grant
    Filed: July 27, 1999
    Date of Patent: August 1, 2000
    Assignee: Nutrimed Biotech
    Inventor: Rajindra Aneja
  • Patent number: 6020506
    Abstract: Disclosed are unique starting materials, reaction sequences and intermediate compounds for the preparation of D-3-phosphorylated phosphoinositides (3-PPI) of unambiguous structure and absolute stereochemistry. The enantiomerically pure D-3-phosphorylated phosphoinositides also provided have many uses, including in the development of diagnostics and therapeutics based on the roles of 3-PPI in intracellular signaling.
    Type: Grant
    Filed: May 23, 1997
    Date of Patent: February 1, 2000
    Assignee: Nutrimed Biotech
    Inventor: Rajindra Aneja
  • Patent number: 4141994
    Abstract: Edible compositions suitable as foodstuff additives or diet supplements for humans and for animals comprising a diet supplementing agent, such as vitamins, vitamin precursors and coloring agents, and an acyl lactylate emulsifier in a weight ratio ranging from 100:1 to 1:100, said compositions having increased efficiency in uptake by a human or animal of the diet supplementing agent. A process for preparing said compositions and rearing of animals on a diet incorporating said edible compositions.
    Type: Grant
    Filed: March 21, 1977
    Date of Patent: February 27, 1979
    Assignee: Internationale Octooimaatschappij "Octropa" B.V.
    Inventors: Rajindra Aneja, Alan P. Davies, Maxwell C. Keith
  • Patent number: RE28903
    Abstract: N-acylphosphatides, for instance N-acetylcephalin, are separated from phosphatides without an acylatabe amino group, for instance lecithin, by making a mixture containing them acid to the equivalent of pH less than 3.5 under aqueous conditions and solvent-fractionating with acetone or methyl acetate.
    Type: Grant
    Filed: November 25, 1974
    Date of Patent: July 13, 1976
    Assignee: Lever Brothers Company
    Inventors: Rajindra Aneja, Jaswinder Singh Chadha
  • Patent number: RE38334
    Abstract: Disclosed are unique starting materials, reaction sequences and intermediate compounds for the preparation of D-3-phosphorylated phosphoinositides (3-PPI) of unambiguous structure and absolute stereochemistry. The enantiomerically pure D-3-phosphorylated phosphoinositides also provided have many uses, including the development of diagnostics and therapeutics based on the roles of 3-PPI in intracellular signaling.
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: November 25, 2003
    Assignee: Nutrimed Biotech
    Inventor: Rajindra Aneja