Patents by Inventor Rajiv Dua
Rajiv Dua has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240084404Abstract: The present invention relates to methods for the specific lysis of eukaryotic cells in a sample containing microorganisms such as bacterium and fungus by incubating the sample in a buffer of around pH 9 that contains a non-ionic detergent.Type: ApplicationFiled: December 23, 2021Publication date: March 14, 2024Inventors: Rajiv Dua, Slav Dugenny, Xiaoyun Zhang
-
Publication number: 20210346719Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. A quantitative time-dependent model-based charged particle pencil beam scanning optimization is then implemented for FLASH therapy.Type: ApplicationFiled: July 22, 2021Publication date: November 11, 2021Inventors: Michael Matthew FOLKERTS, Jessica PEREZ, Christel SMITH, Eric ABEL, Anthony MAGLIARI, Reynald VANDERSTRAETEN, Timo Kalevi KOPONEN, Renate PARRY, Alexander KATSIS, Rajiv DUA, Michiko ALCANZARE, Perttu NIEMELA, Matti ROPO
-
Patent number: 11124840Abstract: Provided herein are methods and compositions to classify DLBCL subtypes using quantitative RT-PCR.Type: GrantFiled: May 11, 2017Date of Patent: September 21, 2021Assignee: Roche Molecular Systems, Inc.Inventors: Rajiv Dua, Marcel Fontecha, Yan Li, Wei-min Liu, Christopher Santini, Lori Steiner, Yu Chuan Tai
-
Patent number: 11103727Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. A quantitative time-dependent model-based charged particle pencil beam scanning optimization is then implemented for FLASH therapy.Type: GrantFiled: June 11, 2019Date of Patent: August 31, 2021Assignees: Varian Medical Systems International AG, Varian Medical Systems Particle Therapy GmbH, Varian Medical Systems, Inc.Inventors: Michael Matthew Folkerts, Jessica Perez, Christel Smith, Eric Abel, Anthony Magliari, Reynald Vanderstraeten, Timo Kalevi Koponen, Renate Parry, Alexander Katsis, Rajiv Dua, Michiko Alcanzare, Perttu Niemela, Matti Ropo
-
Patent number: 11090508Abstract: Embodiments of the present invention provide an integrated solution to radiotherapy treatment planning that enables accurate recording and accumulation of physical parameters as input (e.g., dose, dose rate, irradiation time per voxel, etc.). User-defined functions are evaluated to correlate the input parameters with 4D biological outcomes. The resulting biological parameters can be visualized as a biological outcome map to evaluate decisions, support decisions, and optimize decisions regarding the parameters of the radiotherapy treatment plan, for example, for supporting clinical trials and related clinical research.Type: GrantFiled: March 8, 2019Date of Patent: August 17, 2021Assignees: Varian medical Systems Particle Therapy GmbH & Co. KG, Varian Medical Systems International AG, Varian Medical Systems, Inc.Inventors: Michael Matthew Folkerts, Jessica Perez, Christel Smith, Eric Abel, Anthony Magliari, Reynald Vanderstraeten, Timo Kalevi Koponen, Renate Parry, Alexander Katsis, Rajiv Dua, Michiko Alcanzare, Perttu Niemela, Matti Ropo
-
Publication number: 20200282233Abstract: Embodiments of the present invention provide an integrated solution to radiotherapy treatment planning that enables accurate recording and accumulation of physical parameters as input (e.g., dose, dose rate, irradiation time per voxel, etc.). User-defined functions are evaluated to correlate the input parameters with 4D biological outcomes. The resulting biological parameters can be visualized as a biological outcome map to evaluate decisions, support decisions, and optimize decisions regarding the parameters of the radiotherapy treatment plan, for example, for supporting clinical trials and related clinical research.Type: ApplicationFiled: March 8, 2019Publication date: September 10, 2020Inventors: Michael Matthew FOLKERTS, Jessica PEREZ, Christel SMITH, Eric ABEL, Anthony MAGLIARI, Reynald VANDERSTRAETEN, Timo Kalevi KOPONEN, Renate PARRY, Alexander KATSIS, Rajiv DUA, Michiko ALCANZARE, Perttu NIEMELA, Matti ROPO
-
Publication number: 20200282234Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. A quantitative time-dependent model-based charged particle pencil beam scanning optimization is then implemented for FLASH therapy.Type: ApplicationFiled: June 11, 2019Publication date: September 10, 2020Inventors: Michael Matthew FOLKERTS, Jessica PEREZ, Christel SMITH, Eric ABEL, Anthony MAGLIARI, Reynald VANDERSTRAETEN, Timo Kalevi KOPONEN, Renate PARRY, Alexander KATSIS, Rajiv DUA, Michiko ALCANZARE, Perttu NIEMELA, Matti ROPO
-
Publication number: 20190144947Abstract: Provided herein are methods and compositions to classify DLBCL subtypes using quantitative RT-PCR.Type: ApplicationFiled: May 11, 2017Publication date: May 16, 2019Inventors: Rajiv Dua, Marcel Fontecha, Yan Li, Wei-min Liu, Christopher Santini, Lori Steiner, Yu Chuan Tai
-
Patent number: 10253349Abstract: Provided herein are methods and compositions for detecting gene fusions, e.g., relevant to cancer. The present methods and compositions can be used to detect gene fusions with very high sensitivity and specificity. The present methods and compositions can detect gene fusions, e.g., in free circulating tumor RNA from a plasma sample.Type: GrantFiled: April 15, 2016Date of Patent: April 9, 2019Assignee: Roche Molecular Systems, Inc.Inventors: Ann Begovich, Rajiv Dua, Dwight Kuo, Xiaoju Max Ma, Ellen Ordinario
-
Patent number: 9963748Abstract: Provided herein are methods and compositions to classify DLBCL subtypes using quantitative RT-PCR.Type: GrantFiled: May 11, 2017Date of Patent: May 8, 2018Assignee: Roche Molecular Systems, Inc.Inventors: Rajiv Dua, Marcel Fontecha, Yan Li, Wei-min Liu, Christopher Santini, Lori Steiner, Yu Chuan Tai
-
Publication number: 20170327897Abstract: Provided herein are methods and compositions to classify DLBCL subtypes using quantitative RT-PCR.Type: ApplicationFiled: May 11, 2017Publication date: November 16, 2017Inventors: Rajiv Dua, Marcel Fontecha, Yan Li, Wei-min Liu, Christopher Santini, Lori Steiner, Yu Chuan Tai
-
Publication number: 20160304937Abstract: Provided herein are methods and compositions for detecting gene fusions, e.g., relevant to cancer. The present methods and compositions can be used to detect gene fusions with very high sensitivity and specificity. The present methods and compositions can detect gene fusions, e.g., in free circulating tumor RNA from a plasma sample.Type: ApplicationFiled: April 15, 2016Publication date: October 20, 2016Inventors: Ann Begovich, Rajiv Dua, Dwight Kuo, Xiaoju Max Ma, Ellen Ordinario
-
Patent number: 8247180Abstract: The invention provides methods and kits for detecting and/or measuring receptor homodimers on a cell surface membrane. In one aspect, the methods employ pairs of probes comprising binding compounds and a cleaving probe, such that at least one binding compound binds specifically to the same epitope of a membrane-bound analyte as the cleaving probe. The binding compound includes one or more molecular tags attached through a cleavable linkage, and the cleaving probe includes a cleavage-inducing moiety that can cleave the linkage when within a defined proximity thereto. Binding of the two probes to a homodimer of a cell surface molecules results in release of molecular tags from the binding compounds, providing a measure of formation of the homodimeric complex.Type: GrantFiled: July 18, 2008Date of Patent: August 21, 2012Assignee: Monogram Biosciences, Inc.Inventors: Sailaja Pidaparthi, Yining Shi, Rajiv Dua, Po-Ying Chan-Hui, Sharat Singh
-
Patent number: 8198031Abstract: Methods are provided for detecting the formation of complexes of molecules, especially proteins, in a sample, such as a cell or tissue lysate. In one aspect, a cleaving probe specific for a first protein in a complex and one or more binding compounds specific for one or more second proteins in a complex are provided. Upon binding, the cleaving probe is induced to generate an active species, such as singlet oxygen, that cleaves molecular tags attached to the binding compounds only in the local region of the cleaving probe. The released molecular tags are separated from the assay mixture and from one another to provide a readout that is related to the number and types of proteins present in the complex.Type: GrantFiled: March 12, 2007Date of Patent: June 12, 2012Assignee: Monogram Biosciences, Inc.Inventors: Po-Ying Chan-Yui, Sharat Singh, Hossein Salimi-Moosavi, Yining Shi, Sailaja Pidaparthi, Rajiv Dua, Ali Mukherjee
-
Publication number: 20120003667Abstract: Methods for measuring hetero- and homodimerization of HIV reverse transcriptase (HIV RT) are provided using pairs of tagged probes and cleaving probes. The methods can be used, for example, to screen for modulators of HIV RT dimerization. Also provided are methods of determining whether a compound modulates HIV RT. Further provided are methods of determining whether a compound modulates formation of a complex between a p66 and p51, p66 and p66, or p51 and p55 subunits polypeptides of HIV RT.Type: ApplicationFiled: June 16, 2008Publication date: January 5, 2012Inventors: Soumi Gupta, Rajiv Dua, Douglas McCann
-
Publication number: 20100291594Abstract: The invention is directed to a new class of biomarker in patient samples comprising dimers of ErbB cell surface membrane receptors. In one aspect, the invention includes a method of determining the status of a disease or healthful condition by correlating such condition to amounts of one or more dimers of ErbB cell surface membrane receptors measured directly in a patient sample, in particular a fixed tissue sample. In another aspect, the invention includes a method of determining a status of a cancer in a specimen from an individual by correlating measurements of amounts of one or more dimers of ErbB cell surface membrane receptors in cells of the specimen to such status, including presence or absence of a pre-cancerous state, presence or absence of a cancerous state, prognosis of a cancer, or responsiveness to treatment.Type: ApplicationFiled: January 18, 2010Publication date: November 18, 2010Applicant: Laboratory Corporation of America HoldingsInventors: Po-Ying CHAN-HUI, Rajiv Dua, Ali Mukherjee, Sailaja Pidaparthi, Hossein Salimi-Moosavi, Yining Shi, Sharat Singh
-
Patent number: 7648828Abstract: The invention is directed to a new class of biomarker in patient samples comprising dimers of ErbB cell surface membrane receptors. In one aspect, the invention includes a method of determining the status of a disease or healthful condition by correlating such condition to amounts of one or more dimers of ErbB cell surface membrane receptors measured directly in a patient sample, in particular a fixed tissue sample. In another aspect, the invention includes a method of determining a status of a cancer in a specimen from an individual by correlating measurements of amounts of one or more dimers of ErbB cell surface membrane receptors in cells of the specimen to such status, including presence or absence of a pre-cancerous state, presence or absence of a cancerous state, prognosis of a cancer, or responsiveness to treatment.Type: GrantFiled: January 21, 2005Date of Patent: January 19, 2010Assignee: Monogram Biosciences, Inc.Inventors: Po-Ying Chan-Hui, Rajiv Dua, Ali Mukherjee, Sailaja Pidaparthi, Hossein Salimi-Moosavi, Yining Shi, Sharat Singh
-
Publication number: 20090155818Abstract: The invention provides methods and kits for detecting and/or measuring receptor homodimers on a cell surface membrane. In one aspect, the methods employ pairs of probes comprising binding compounds and a cleaving probe, such that at least one binding compound binds specifically to the same epitope of a membrane-bound analyte as the cleaving probe. The binding compound includes one or more molecular tags attached through a cleavable linkage, and the cleaving probe includes a cleavage-inducing moiety that can cleave the linkage when within a defined proximity thereto. Binding of the two probes to a homodimer of a cell surface molecules results in release of molecular tags from the binding compounds, providing a measure of formation of the homodimeric complex.Type: ApplicationFiled: July 18, 2008Publication date: June 18, 2009Applicant: Monogram Biosciences, Inc.Inventors: Sailaja Pidaparthi, Yining Shi, Rajiv Dua, Po-Ying Chan-Hui, Sharat Singh
-
Publication number: 20090111127Abstract: The invention is directed to a new class of biomarker in patient samples comprising dimers of cell surface membrane receptors. In one aspect, the invention includes a method of determining the status of a disease or healthful condition by correlating such condition to amounts of one or more dimers of cell surface membrane receptors measured directly in a patient sample, in particular a fixed tissue sample. In another aspect, the invention includes a method of determining a status of a cancer in a specimen from an individual by correlating measurements of amounts of one or more dimers of cell surface membrane receptors in cells of the specimen to such status, including presence or absence of a pre-cancerous state, presence or absence of a cancerous state, prognosis of a cancer, or responsiveness to treatment. Preferably, methods of the invention are implemented by using sets of binding compounds having releasable molecular tags that are specific for multiple components of one or more types of receptor dimers.Type: ApplicationFiled: October 2, 2007Publication date: April 30, 2009Inventors: Po-Ying Chan-Hui, Rajiv Dua, Ali Mukherjee, Sailaja Pidaparthi, Hossein Salimi-Moosavi, Yining Shi, Sharat Singh
-
Patent number: RE44437Abstract: The invention is directed to a new class of biomarker in patient samples comprising dimers of ErbB cell surface membrane receptors. In one aspect, the invention includes a method of determining the status of a disease or healthful condition by correlating such condition to amounts of one or more dimers of ErbB cell surface membrane receptors measured directly in a patient sample, in particular a fixed tissue sample. In another aspect, the invention includes a method of determining a status of a cancer in a specimen from an individual by correlating measurements of amounts of one or more dimers of ErbB cell surface membrane receptors in cells of the specimen to such status, including presence or absence of a pre-cancerous state, presence or absence of a cancerous state, prognosis of a cancer, or responsiveness to treatment.Type: GrantFiled: January 18, 2012Date of Patent: August 13, 2013Assignee: Monogram Biosciences, Inc.Inventors: Po-Ying Chan-Hui, Rajiv Dua, Ali Mukherjee, Sailaja Pidaparthi, Hossein Salimi-Moosavi, Yining Shi, Sharat Singh