Abstract: The technical field of the present invention relates to the selection of lubricants to provide a storage stable tablet of fosinopril, alone or in combination with a diuretic, as well as processes of preparation of the stable tablets. In particular, the lubricants are a combination of colloidal silicon dioxide and talc.

Abstract: The present invention relates to the preparation of a nanoparticulate isotretinoin composition having enhanced bioavailability.

Abstract: This invention relates to a stable topical formulation of clarithromycin and its use in the treatment of acne.

Abstract: The invention relates to processes for preparing, and pharmaceutical compositions of, modafinil dosage forms for oral administration. The dosage forms include a mixture of coarse and fine particles of modafinil. The process for preparing modafinil oral dosage forms includes forming a dosage form that includes about 7%-25% by weight of modafinil particles having diameters greater than 220 &mgr;m and about 75%-93% by weight of modafinil particles having diameters less than 220 &mgr;m.

Abstract: The present invention relates to a stable pharmaceutical composition comprising pravastatin or its pharmaceutically acceptable salts and a carrier, which imparts a pH between 6.5 and 8.5 to an aqueous dispersion of said composition. The invention also relates to a process for making the pharmaceutical composition.

Abstract: The present invention relates to a bioavailable pharmaceutical composition of 13-cis vitamin A acid (also known as 13-cis retinoic acid and isotretinoin) and a process for preparing the same. 13-cis vitamin A acid is a relatively water insoluble compound that degrades when exposed to light and atmospheric oxygen. Due to its instability and relative insolubility, the bioavailability of the drug after oral administration is difficult to achieve and has always been a challenge to a development pharmacist. It would therefore be desirable to provide a dosage form in which the drug is stable and predictably bioavailable.

Abstract: The present invention relates to an extended release pharmaceutical composition containing metformin and a rate controlling polymer and a process for the preparation thereof.

Abstract: A pharmaceutical formulation having improved bioavailability and bioequivalence includes particles of amorphous and/or crystalline atorvastatin that have a particle size (d90) less than 150 &mgr;m and a mean particle size (d50) of the atorvastatin particles that is between approximately 5 and 50 &mgr;m. The atorvastatin can be one or more of atorvastatin calcium, atorvastatin magnesium, atorvastatin aluminum, atorvastatin iron, and atorvastatin zinc. The formulations of atorvastatin can be stabilized by mixing atorvastatin with an alkali metal salt additive at between approximately 1.2% and less than 5% w/w of the formulation.

Abstract: The present invention relates to fast dissolving tablets for oral administration comprising a therapeutically effective amount of drug(s) that acts selectively as a cyclooxygenase-2 (COX-2) enzyme inhibitor, which disintegrate quickly in mouth. The tablets are particularly suitable for patients who have difficulty in swallowing.

Abstract: Configuration management of managed objects is performed based upon performance data. Configuration management is performed on varying levels according to the amount of interpretation of the performance data that is required. A new configuration for an object is determined based upon the performance data, and the object is reconfigured according to the new configuration. Analysis may be performed at varying levels by a reactive analyzer and a deliberative analyzer.

Abstract: Method and apparatus for determining an enforceable policy applicable to one or more network devices. The method includes attaching one or more rule elements to one or more domain elements to create policies, the domain elements representing network devices and groups of network devices, and the rule elements defining actions, a method for determining whether a conflict exists between the polices, and a method for resolving the conflicts to produce one or more enforceable policies.

Abstract: A bioavailable oral dosage form of loratadine of specific particle size and surface area.

Abstract: The present invention relates to a bioavailable pharmaceutical composition of 13-cis vitamin A acid (also known as 13-cis retinoic acid and isotretinoin) and a process for preparing the same. 13-cis vitamin A acid is a relatively water insoluble compound that degrades when exposed to light and atmospheric oxygen. Due to its instability and relative insolubility, the bioavailability of the drug after oral administration is difficult to achieve and has always been a challenge to a development pharmacist. It would therefore be desirable to provide a dosage form in which the drug is stable and predictably bioavailable.

Abstract: Apparatus and method for monitoring parameters that govern the operational characteristics of a network device, including the use of templates for generating configuration records of network devices of a selected model type. A database of models is provided, each model representing an associated network device and including attribute values for the parameters of the associated network device. Templates are used to screen a model in order to retrieve values for each of the attributes and create a configuration record. The configuration records may be stored in the configuration manager or other storage device, and/or transferred to the pre-existing model database for use by a network management system in reconfiguring the associated network devices. This system for configuration management is less time consuming, expensive, and error prone than prior systems.

Abstract: Apparatus and method for monitoring parameters that govern the operational characteristics of a network device, including the use of templates for generating configuration records of network devices of a selected model type. A database of models is provided, each model representing an associated network device and including attribute values for the parameters of the associated network device. Templates are used to screen a model in order to retrieve values for each of the attributes and create a configuration record. The configuration records may be stored in the configuration manager or other storage device, and/or transferred to the pre-existing model database for use by a network management system in reconfiguring the associated network devices. Additionally, a method and apparatus is provided that defines network groups, defines network policies for groups, determines conflicts, and resolves conflicts among groups and devices.

Abstract: Method and apparatus for determining an enforceable policy applicable to one or more network devices. The method includes attaching one or more rule elements to one or more domain elements to create policies, the domain elements representing network devices and groups of network devices, and the rule elements defining actions, a method for determining whether a conflict exists between the polices, and a method for resolving the conflicts to produce one or more enforceable policies.

Abstract: Apparatus and method for monitoring parameters that govern the operational characteristics of a network device, including the use of templates for generating configuration records of network devices of a selected model type. A database of models is provided, each model representing an associated network device and including attribute values for the parameters of the associated network device. Templates are used to screen a model in order to retrieve values for each of the attributes and create a configuration record. The configuration records may be stored in the configuration manager or other storage device, and/or transferred to the pre-existing model database for use by a network management system in reconfiguring the associated network devices. Additionally, a method and apparatus is provided that defines network groups, defines network policies for groups, determines conflicts, and resolves conflicts among groups and devices.

Abstract: Apparatus and method for monitoring parameters that govern the operational characteristics of a network device, including the use of templates for generating configuration records of network devices of a selected model type. A database of models is provided, each model representing an associated network device and including attribute values for the parameters of the associated network device. Templates are used to screen a model in order to retrieve values for each of the attributes and create a configuration record. The configuration records may be stored in the configuration manager or other storage device, and/or transferred to the pre-existing model database for use by a network management system in reconfiguring the associated network devices. This system for configuration management is less time consuming, expensive, and error prone than prior systems.