Patents by Inventor Rajiv Saigal
Rajiv Saigal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11607383Abstract: The present disclosure describes a method of delivering a therapeutic agent providing a microneedle array including a plurality of microneedles, the plurality of microneedles including a conductive coating disposed thereon, wherein the conductive coating includes the therapeutic agent and a conducting polymer; implanting the microneedle array in a dura mater of a subject in need thereof, wherein the microneedle array pierces the dura mater; and applying an electrical stimulus to the microneedle array to provide a controlled release of the therapeutic agent from the conductive coating, across the dura mater, to the central nervous system of the subject.Type: GrantFiled: October 13, 2020Date of Patent: March 21, 2023Assignee: University of WashingtonInventors: Rajiv Saigal, Joyce Huang
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Publication number: 20220401355Abstract: Devices for and related methods of treating a subject having a neurological injury to prevent or mitigate secondary injury are described. In an example, the devices include a base and a plurality of microneedles protruding from the base, the microneedles including a biocompatible and biodegradable matrix, and a neurologically active ingredient disposed within the matrix. In an example, a portion of the plurality of microneedles is shaped to penetrate the dura when the device is placed in contact with the dura.Type: ApplicationFiled: May 13, 2022Publication date: December 22, 2022Applicants: University of Washington, The Regents of the University of CaliforniaInventors: Rajiv Saigal, Jessica Johnson, Tianyu Zhao, Maximilian Walter
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Publication number: 20210106520Abstract: The present disclosure describes a method of delivering a therapeutic agent providing a microneedle array including a plurality of microneedles, the plurality of microneedles including a conductive coating disposed thereon, wherein the conductive coating includes the therapeutic agent and a conducting polymer; implanting the microneedle array in a dura mater of a subject in need thereof, wherein the microneedle array pierces the dura mater; and applying an electrical stimulus to the microneedle array to provide a controlled release of the therapeutic agent from the conductive coating, across the dura mater, to the central nervous system of the subject.Type: ApplicationFiled: October 13, 2020Publication date: April 15, 2021Applicant: University of WashingtonInventors: Rajiv Saigal, Joyce Huang
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Publication number: 20210101002Abstract: Systems and methods for fusing vertebrae and systems and methods for repairing a bone defect employ a fixation assembly and current delivered to the fixation assembly to electrically stimulate osteogenesis in tissue surrounding the fixation assembly. An implantable system for fusing vertebrae includes a fixation assembly and an implantable stimulation unit. The fixation assembly includes an elongated rod configured to accommodate bone ingrowth. The fixation assembly is configured to structurally couple at least two of the two or more vertebrae via the elongated rod. The implantable stimulation unit is configured to supply electrical current to the elongated rod to promote bone ingrowth into the elongated rod.Type: ApplicationFiled: October 1, 2020Publication date: April 8, 2021Inventors: Rajiv Saigal, Samantha Kokoska, Alexis Fleming, Taylor Monroe-Jones, Kai-Bin Ooi, Alejandro Diaz
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Publication number: 20190038808Abstract: Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.Type: ApplicationFiled: October 5, 2018Publication date: February 7, 2019Inventors: Robert S. Langer, Rajiv Saigal, Yang Teng
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Publication number: 20180169302Abstract: Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.Type: ApplicationFiled: February 14, 2018Publication date: June 21, 2018Inventors: Robert S. Langer, Rajiv Saigal, Yang Teng
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Publication number: 20160339150Abstract: Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.Type: ApplicationFiled: August 5, 2016Publication date: November 24, 2016Inventors: Robert S. Langer, Rajiv Saigal, Yang Teng
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Patent number: 9440008Abstract: Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.Type: GrantFiled: April 23, 2015Date of Patent: September 13, 2016Assignees: Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Robert S. Langer, Rajiv Saigal, Yang Teng
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Patent number: 9173732Abstract: Provided herein are new methods for the treatment of hyperproliferative diseases affecting the spinal cord, including the use of biodegradable polymers to treat spinal cord tumor recessing, i.e., to patch open zones left by spinal tumor removal. Biocompatible polymeric materials are tailored to fill areas previously occupied by tumors, e.g., materials in the form of tubular articles configured for insertion into the spinal column after surgical removal of a tumor. These protective articles may also include medicinal agents that stimulate spinal column neural regeneration, such as medicines or donor neuronal cells such as human neural stem cells, thus assisting patients to recover motorsensory function after spinal tumor surgery.Type: GrantFiled: August 5, 2008Date of Patent: November 3, 2015Assignees: The Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Robert S. Langer, Rajiv Saigal, Yang Teng, Eric Woodard
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Publication number: 20150297799Abstract: Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.Type: ApplicationFiled: April 23, 2015Publication date: October 22, 2015Inventors: Robert S. Langer, Rajiv Saigal, Yang Teng
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Patent number: 9101695Abstract: Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.Type: GrantFiled: September 25, 2014Date of Patent: August 11, 2015Assignees: Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Robert S. Langer, Rajiv Saigal, Yang Teng
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Publication number: 20150030659Abstract: Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.Type: ApplicationFiled: September 25, 2014Publication date: January 29, 2015Inventors: Robert S. Langer, Rajiv Saigal, Yang Teng
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Patent number: 8858966Abstract: Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.Type: GrantFiled: February 11, 2014Date of Patent: October 14, 2014Assignees: Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Robert S. Langer, Rajiv Saigal, Yang Teng
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Publication number: 20140161861Abstract: Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.Type: ApplicationFiled: February 11, 2014Publication date: June 12, 2014Applicants: Massachusetts Institute of Technology, Children's Medical Center CorporationInventors: Robert S. Langer, Rajiv Saigal, Yang Teng
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Patent number: 8685434Abstract: Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.Type: GrantFiled: January 15, 2013Date of Patent: April 1, 2014Assignees: Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Robert S. Langer, Rajiv Saigal, Yang Teng
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Patent number: 8377463Abstract: Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.Type: GrantFiled: April 25, 2007Date of Patent: February 19, 2013Assignees: Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Robert Langer, Rajiv Saigal, Yang Teng
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Publication number: 20090053284Abstract: Provided herein are new methods for the treatment of hyperproliferative diseases affecting the spinal cord, including the use of biodegradable polymers to treat spinal cord tumor recessing, i.e., to patch open zones left by spinal tumor removal. Biocompatible polymeric materials are tailored to fill areas previously occupied by tumors, e.g., materials in the form of tubular articles configured for insertion into the spinal column after surgical removal of a tumor. These protective articles may also include medicinal agents that stimulate spinal column neural regeneration, such as medicines or donor neuronal cells such as human neural stem cells, thus assisting patients to recover motorsensory function after spinal tumor surgery.Type: ApplicationFiled: August 5, 2008Publication date: February 26, 2009Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Robert S. LANGER, Rajiv SAIGAL, Yang TENG, Eric WOODARD
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Publication number: 20070259020Abstract: Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.Type: ApplicationFiled: April 25, 2007Publication date: November 8, 2007Inventors: Robert Langer, Rajiv Saigal, Yang Teng