Abstract: The present disclosure relates to, among other things, compositions and methods for treating pain such as neuropathic pain, ocular pain, chronic pain, pain resulting from chemotherapy or radiation, and pain resulting from nerve injury or nerve degeneration. In some embodiments, the pain can be resulting from an inflammatory condition, dysesthesia, or allodynia. The present disclosure also relates to methods for treating an inflammatory condition such as ocular inflammation, retinal inflammation, dry eye, uveitis, allergic conjunctivitis, and inflammation resulting from nerve injury or nerve degeneration.

Abstract: The present disclosure relates to peptide compositions and methods for treating an inflammatory condition such as ocular inflammation, retinal inflammation, dry eye, uveitis, allergic conjunctivitis, and inflammation resulting from nerve injury or nerve degeneration. The peptide compositions disclosed herein can also be used for treating pain such as neuropathic pain, ocular pain, chronic pain, pain resulting from chemotherapy or radiation, pain resulting from nerve injury or nerve degeneration, and pain resulting from an inflammatory condition, dysesthesia, or allodynia.

Abstract: RNA interference is provided for inhibition of aquaporin 1 (AQP1) to treat conditions associated with neovascularization.

Abstract: RNA interference is provided for inhibition of aquaporin 4 (AQP4) in intraocular pressure-related conditions, including ocular hypertension and glaucoma such as normal tension glaucoma and open angle glaucoma.

Abstract: RNA interference is provided for inhibition of aquaporin 4 (AQP4) to treat conditions associated with neovascularization.

Abstract: RNA interference is provided for inhibition of aquaporin 1 (AQP1) in intraocular pressure-related conditions, including ocular hypertension and glaucoma such as normal tension glaucoma and open angle glaucoma.