Patents by Inventor Rajkumar Verma

Rajkumar Verma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR PHARMACOLOGIC TREATMENT OF STROKE AND MYOCARDIAL ISCHEMIA REPERFUSION INJURY
    Publication number: 20250360143
    Abstract: Compositions and methods for the treatment of a human subject who has had a stroke or myocardial ischemia reperfusion injury, by administering to the subject a pharmaceutical composition including a compound of Formula (I) and/or of Formula (5) or a pharmaceutically acceptable salt and/or formulation thereof. The pharmaceutical composition can be administered in the acute phase of stroke, optionally in combination with a thrombolytic therapeutic or a procedure on the subject involving a clot-removal device.
    Type: Application
    Filed: June 7, 2023
    Publication date: November 27, 2025
    Inventors: Bruce T. Liang, Rajkumar Verma, Kenneth A. Jacobson, Kiran S. Toti
  • miR-141-3p MODULATORS AND USES THEREOF
    Publication number: 20250136985
    Abstract: Disclosed herein is a pharmaceutically effective composition comprising at least one of a phosphorothioate (PS)-based anti-miR-141-3p oligonucleotide; a peptide nucleic acid (PNA)-based anti-miR-141-3p oligonucleotide; and/or a gamma-peptide nucleic acid (?-PNA)-based anti-miR-141-3p oligonucleotide; where at least one of the foregoing oligonucleotides is encapsulated in a biocompatible nanoparticle.
    Type: Application
    Filed: October 10, 2024
    Publication date: May 1, 2025
    Inventors: Rajkumar Verma, Sanjeev Kumar Yadav, Raman Bahal, Karishma Dhuri
  • Methods for pharmacologic treatment of stroke
    Patent number: 10695355
    Abstract: Described herein are methods for the treatment of a human subject who has had a stroke by administering to the subject a pharmaceutical composition including an antagonist of the P2X4 receptor. The antagonist of the P2X4 receptor can be administered in the acute phase of stroke, optionally in combination with a thrombolytic therapeutic or a procedure on the subject involving a clot-removal device.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: June 30, 2020
    Assignees: UNIVERSITY OF CONNECTICUT, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Bruce Liang, Rajkumar Verma, Kenneth A. Jacobson
  • METHODS FOR PHARMACOLOGIC TREATMENT OF STROKE
    Publication number: 20180280409
    Abstract: Described herein are methods for the treatment of a human subject who has had a stroke by administering to the subject a pharmaceutical composition including an antagonist of the P2X4 receptor. The antagonist of the P2X4 receptor can be administered in the acute phase of stroke, optionally in combination with a thrombolytic therapeutic or a procedure on the subject involving a clot-removal device.
    Type: Application
    Filed: March 23, 2018
    Publication date: October 4, 2018
    Inventors: Bruce Liang, Rajkumar Verma, Kenneth A. Jacobson