Patents by Inventor Rajmahendra Shanmughasamy

Rajmahendra Shanmughasamy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Trisodium sacubitril valsartan and process for its preparation
    Patent number: 11629120
    Abstract: The present invention provides for methyl)-4-amino-2R-methyl butanoic acid ethyl ester sodium salt, a novel process for the preparation of crystalline Form B of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-2R-methyl butanoic acid ethyl ester sodium salt.
    Type: Grant
    Filed: November 5, 2020
    Date of Patent: April 18, 2023
    Assignee: BIOCON LIMITED
    Inventors: Palle Venkata Raghavendra Charyulu, Pratik Rameshchandra Patel, Thirunelimada Devaiah Venu, Reddy Avathu Vidyasagar, Rajmahendra Shanmughasamy
  • Amorphous Trisodium Sacubitril Valsartan and process for its preparation
    Patent number: 10995060
    Abstract: The present invention provides for crystalline Form B1 of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenyl-methyl)-4-amino-2R-methyl butanoic acid ethyl ester sodium salt, crystalline Form B2 of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-2R-methyl butanoic acid ethyl ester sodium salt, a novel process for the preparation of crystalline Form B of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-2R-methyl butanoic acid ethyl ester sodium salt.
    Type: Grant
    Filed: October 28, 2017
    Date of Patent: May 4, 2021
    Assignee: BIOCON LIMITED
    Inventors: Palle Venkata Raghavendra Charyulu, Pratik Rameshchandra Patel, Thirunelimada Devaiah Venu, Reddy Avathu Vidyasagar, Rajmahendra Shanmughasamy
  • AMORPHOUS TRISODIUM SACUBITRIL VALSARTAN AND PROCESS FOR ITS PREPARATION
    Publication number: 20210122708
    Abstract: The present invention provides for crystalline Form B1 of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenyl-methyl)-4-amino-2R-methyl butanoic acid ethyl ester sodium salt, crystalline Form B2 of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-2R-methyl butanoic acid ethyl ester sodium salt, a novel process for the preparation of crystalline Form B of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-2R-methyl butanoic acid ethyl ester sodium salt. The present invention also provides for crystalline Form B of (S)—N-(1-Carboxy-2-Methyl-Prop-1-yl)-N-Pentanoyl-N-[2?-(1H-Tetrazol-5-yl)-Biphenyl-4-yl-Methyl]-Amine disodium salt, crystalline Form P of (S)—N-(1-Carboxy-2-Methyl-Prop-1-yl)-N-Pentanoyl-N-[2?-(1H-Tetrazol-5-yl)-Biphenyl-4-yl-Methyl]-Amine disodium salt and processes for their preparation thereof. The present invention further provides an industrial method production of Amorphous Form of Sacubitril valsartan trisodium.
    Type: Application
    Filed: November 5, 2020
    Publication date: April 29, 2021
    Inventors: PALLE VENKATA RAGHAVENDRA CHARYULU, PRATIK RAMESHCHANDR PATEL, THIRUNELIMADA DEVAIAH VENU, REDDY AVATHU VIDYASAGAR, RAJMAHENDRA SHANMUGHASAMY
  • Process for the preparation of teriflunomide
    Patent number: 10526279
    Abstract: The present invention provides a process for the preparation of Teriflunomide (Formula-I). The present invention describes the synthesis of Teriflunomide without isolating the intermediate Leflunomide. Teriflunomide is prepared from 5-Methyl isoxazole-4-carboxylic acid by converting to its acid chloride and coupling with 4-trifluoromethyl aniline to obtain Leflunomide (which is not isolated) followed by ring opening reaction using aq. Sodium Hydroxide to form Teriflunomide. In other words, the process is telescoped from 5-methylisoxazole-4-carbonyl chloride.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: January 7, 2020
    Assignee: BIOCON LIMITED
    Inventors: Venkata Raghavendracharyulu Palle, Ramakrishna Parameshwar Bhat, Mariappan Kaliappan, Jithendra R. Babu, Rajmahendra Shanmughasamy
  • AMORPHOUS TRISODIUM SACUBITRIL VALSARTAN AND PROCESS FOR ITS PREPARATION
    Publication number: 20190322615
    Abstract: The present invention provides for crystalline Form B1 of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenyl-methyl)-4-amino-2R-methyl butanoic acid ethyl ester sodium salt, crystalline Form B2 of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-2R-methyl butanoic acid ethyl ester sodium salt, a novel process for the preparation of crystalline Form B of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-2R-methyl butanoic acid ethyl ester sodium salt. The present invention also provides for crystalline Form B of (S)—N-(1-Carboxy-2-Methyl-Prop-1-yl)-N-Pentanoyl-N-[2?-(1H-Tetrazol-5-yl)-Biphenyl-4-yl-Methyl]-Amine disodium salt, crystalline Form P of (S)—N-(1-Carboxy-2-Methyl-Prop-1-yl)-N-Pentanoyl-N-[2?-(1H-Tetrazol-5-yl)-Biphenyl-4-yl-Methyl]-Amine disodium salt and processes for their preparation thereof. The present invention further provides an industrial method production of Amorphous Form of Sacubitril valsartan trisodium.
    Type: Application
    Filed: October 28, 2017
    Publication date: October 24, 2019
    Inventors: PALLE VENKATA RAGHAVENDRA CHARYULU, PRATIK RAMESHCHANDRA PATEL, THIRUNELIMADA DEVAIAH VENU, REDDY AVATHU VIDYASAGAR, RAJMAHENDRA SHANMUGHASAMY
  • A NOVEL PROCESS FOR THE PREPARATION OF TERIFLUNOMIDE
    Publication number: 20180170859
    Abstract: The present invention provides a process for the preparation of Teriflunomide (Formula-I). The present invention describes the synthesis of Teriflunomide without isolating the intermediate Leflunomide. Teriflunomide is prepared from 5-Methyl isoxazole-4-carboxylic acid by converting to its acid chloride and coupling with 4-trifluoromethyl aniline to obtain Leflunomide (which is not isolated) followed by ring opening reaction using aq. Sodium Hydroxide to form Teriflunomide. In other words, the process is telescoped from 5-methylisoxazole-4-carbonyl chloride.
    Type: Application
    Filed: June 16, 2016
    Publication date: June 21, 2018
    Inventors: Venkata Raghavendracharyulu Palle, Ramakrishna Parameshwar Bhat, Mariappan Kaliappan, Jithendra R. Babu, Rajmahendra Shanmughasamy