Abstract: A group of .beta.-blockers represented by the formula ##STR1## wherein R is ##STR2## or ##STR3## and the physiologically compatible acid addition salts thereof. These .beta.-blockers are .beta.-adrenergic receptor blocking agents which are useful in the treatment of angina pectoris, heart arrhythmia, and high blood pressure.

Abstract: Adenosine-5'-carboxylic acid amides represented by the formula ##STR1## wherein R.sub.1 and R.sub.2 are each selected from the group consisting of hydrogen, loweralkyl, lowerhaloalkyl, lowerhydroxyalkyl, lowercycloalkyl, loweralkylcycloalkyl, loweralkenyl, lowerhaloalkenyl, lowerhydroxyalkenyl, loweralkynyl, lowerhaloalkynyl, benzylamino, phenyl, loweralkylphenyl, loweralkoxyloweralkyl, substituted phenyl, 2-methylfuran or di(C.sub.1 -C.sub.4)alkylamino(C.sub.1 -C.sub.4)alkyl, adamantyl or R.sub.1 and R.sub.2 taken together form a 5 or 6 membered heterocyclic moiety; R.sub.3 and R.sub.4 are hydrogen or acyl, or taken together form an isopropylidene or a benzylidene group; or a pharmaceutically acceptable acid addition salt thereof.

Abstract: 2-Substituted adenosine-5'-carboxylates represented by the formula ##SPC1##Wherein R is amino, acetamido or hydroxy, R.sub.1 is loweralkyl, haloloweralkyl, hydroxyloweralkyl, lowercycloalkyl, loweralkenyl, loweralkynyl, loweralkyl(C.sub.3 -C.sub.6)cycloalkyl or alkoxyalkyl and R.sub.2 and R.sub.3 each are hydrogen or acyl, or R.sub.2 and R.sub.3 taken together form an isopropylidene or benzylidene moiety; and the pharmaceutically acceptable acid addition salts thereof. The compounds wherein R.sub.2 and R.sub.3 are hydrogen or acyl are useful in treating cardiovascular disorders and are particularly useful as anti-anginal agents. Compounds wherein R.sub.2 and R.sub.3 when taken together form an isopropylidene or benzylidene moiety are intermediates useful in making the final products.

Abstract: Esters of 1,N.sup.6 -etheno-5'-adenosine carboxylic acid represented by the formula ##SPC1##Wherein R.sub.1 is loweralkyl, loweralkenyl, loweralkynyl or cycloalkyl; and R.sub.2 and R.sub.3 each are hydrogen or acyl, or R.sub.2 and R.sub. 3 taken together form an isopropylidene or benzylidene moiety; and the pharmaceutically acceptable acid addition salts thereof.The compounds wherein R.sub.2 and R.sub.3 are hydrogen are useful in treating cardiovascular disorders and are particularly useful as anti-anginal and anti-hypertensive agents. Compounds wherein R.sub.2 and R.sub.3 are acyl or when taken together form an isopropylidene or benzylidene moiety are intermediates useful in the preparation of the final products. (R.sub.2 and R.sub.3 = hydrogen). The final products are also useful as intermediates for preparing pharmaceutically active compounds, and, more specifically, for preparing the corresponding 1,N.sup.6 -etheno-5'-adenosine carboxamides.

Abstract: Adenosine-5'-carboxamides which are effective as platelet aggregation inhibitors and represented by the formula ##SPC1##Wherein R is hydrogen, loweralkyl, lowercycloalkyl, loweralkenyl, or lowerhydroxyalkyl.

Abstract: Amides of 1,N.sup.6 -Etheno-5'-adensine carboxylic acid represented by the formula ##SPC1##Wherein R.sub.1 and R.sub.2 each are hydrogen, loweralkyl, loweralkenyl, loweralkynyl or cycloalkyl, and R.sub.3 and R.sub.4 each are hydrogen, acyl, or R.sub.3 and R.sub.4 taken together form an isopropylidene or benzylidene moiety; and the pharmaceutically acceptable acid addition salts thereof.The compounds wherein R.sub.3 and R.sub.4 are hydrogen are useful in treating cardiovascular disorders and are particularly useful as anti-anginal and anti-hypertensive agents. Compounds wherein R.sub.3 and R.sub.4 are acyl or when taken together form an isopropylidene or benzylidene moiety are intermediates useful in the preparation of the final products. (R.sub.3 and R.sub.4 = hydrogen).