Abstract: The present invention provides clinical evidence for a method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring myeloablative conditioning.

Abstract: Provided herein is a crystalline form of selpercatinib useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders, and methods of making this crystalline form.

Abstract: Provided herein are methods of preparing crystalline, selpercatinib Form A, which contains little to none of the thermodynamically more stable, crystalline selpercatinib Form B. Selpercatinib is useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: The present invention provides clinical evidence for a method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring myeloablative conditioning.

Abstract: An electronic device comprises a semiconductor substrate including majority carrier dopants of a first conductivity type, a semiconductor surface layer including majority carrier dopants of a second conductivity type, field oxide that extends on the semiconductor surface layer, and an isolation structure. The isolation structure includes a trench that extends through the semiconductor surface layer and into one of the semiconductor substrate and a buried layer of the semiconductor substrate, and polysilicon including majority carrier dopants of the second conductivity type, the polysilicon fills the trench to a side of the semiconductor surface layer.

Abstract: Methods for the synthesis of harmine comprise reacting harmaline with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in the presence of a diacid catalyst. In an embodiment, the synthesis is carried out using a reaction mixture of harmaline, DDQ, THF solvent, and succinic acid; the reaction is carried out under an inert atmosphere with refluxing for a period of 4-12 hours.

Abstract: An electrical system for a wind turbine having a reduced uptower footprint and method for achieving the same are provided. Accordingly, the electrical system includes a plurality of electrical subsystems having a plurality of electrical subsystem assemblies. At least one electrical subsystem assembly is integrated with the generator housing. Additionally, the electrical subsystem assembly is coupled between the stator or the rotor of the generator and the generator output connection. The electrical system incorporating the electrical subsystem assembly with the generator housing has a reduced uptower footprint relative to a nominal design of an electrical system.

Abstract: A method for controlling an energy generation and storage system using a multi-layer architecture is provided. The method includes determining, by one or more control devices, a power or energy generation for the energy generation and storage system at a first layer of the multi-layer architecture. The method includes determining, by the one or more control devices, a power or energy set point for the system at a second layer of the multi-layer architecture. The method includes controlling, by the one or more control devices, the energy generation and storage system based, at least in part, on the power or energy setpoint.

Abstract: A method for controlling an electrical power system connected to a power grid includes receiving a reactive power command and a measured reactive power and generating a reactive power error signal based on a difference between the reactive power command and the measured reactive power. Further, the method includes receiving, via a reactive power regulator, the reactive power error signal. Moreover, the method includes generating, via the reactive power regulator, a voltage command based on the error signal. The method also includes generating, via a droop control, a voltage droop signal. In addition, the method includes generating a voltage error signal as a function of the voltage droop signal and at least one of the voltage command or a measured terminal voltage. Thus, the method further includes generating, via a voltage regulator, a reactive current command based on the voltage error signal.

Abstract: A crosslinkable coating composition comprising: ingredient A that has at least two protons that can be activated to form a Michael carbanion donor, wherein ingredient A is selected from the group consisting of an acetoacetate group containing compound, an acetoacetate group containing oligomer, an acetoacetate group containing polymer and combinations thereof; ingredient B that functions as a Michael acceptor having at least two ethylenically unsaturated functionalities each activated by an electron-withdrawing group; a surface modifying agent selected from the group consisting of perfluorosurfactants, polyacrylates, polyacrylate copolymers, fluorocarbon polyacrylates, fluorocarbon polyacrylate copolymers, polysiloxane and copolymers thereof and combinations thereof; and a chemical activator.

Abstract: A crosslinkable coating composition comprising: ingredient A that has at least two protons that can be activated to form a Michael carbanion donor; ingredient B that functions as a Michael acceptor having at least two ethylenically unsaturated functionalities each activated by an electron-withdrawing group; and a dormant carbamate initiator of Formula (1) wherein R1 and R2 can be independently selected from hydrogen, a linear or branched substituted or unsubstituted alkyl group having 1 to 22 carbon atoms; 1 to 8 carbon atoms; and An+ is a cationic species or polymer and n is an integer equal or greater than 1 with the proviso that An+ is not an acidic hydrogen; and optionally further comprising ammonium carbamate (H2NR1R2+?OC?ONR1R2). The crosslinkable coating composition can be used for a variety of coating applications including nail coating compositions.

Abstract: Low-temperature syntheses of thymoquinone/harmaline compounds which are useful for the treatment of human diabetes and cancers, and the derivatives, solvates, prodrugs, isomers, and tautomers of such compounds.

Abstract: A crosslinkable coating composition comprising: ingredient A that has at least two protons that can be activated to form a Michael carbanion donor; ingredient B that functions as a Michael acceptor having at least two ethylenically unsaturated functionalities each activated by an electron-withdrawing group; and a dormant carbamate initiator of Formula (1) wherein R1 and R2 can be independently selected from hydrogen, a linear or branched substituted or unsubstituted alkyl group having 1 to 22 carbon atoms; 1 to 8 carbon atoms; and An+ is a cationic species or polymer and n is an integer equal or greater than 1 with the proviso that An+ is not an acidic hydrogen; and optionally further comprising ammonium carbamate (H2NR1R2+?OC?ONR1R2). The crosslinkable coating composition can be used for a variety of coating applications including nail coating compositions.

Abstract: A data processing method comprising: receiving, from each of a plurality of sensors each located at a respective location, a signal indicative of a respective value of a parameter measured by that sensor at a respective one of a plurality of successive times; and determining, based on the value of the parameter measured by one or more first sensors of the plurality of sensors at a respective one or more of the plurality of successive times, a value of the parameter at the location of a second sensor of the plurality of sensors at one of the one or more of the plurality of successive times.

Abstract: Methods for the synthesis of harmine comprise reacting harmaline with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in the presence of a diacid catalyst. In an embodiment, the synthesis is carried out using a reaction mixture of harmaline, DDQ, THF solvent, and succinic acid; the reaction is carried out under an inert atmosphere with refluxing for a period of 4-12 hours.

Abstract: A hybrid power plant including a plurality of power sources and controllers, a hybrid plant controller, and a computing system. The controllers operate the power sources according to operating set points. The hybrid plant controller transmits the operating set points to the controllers. The computing system is coupled to the hybrid plant controller and receives a first set of input parameters from a first subscriber, and carries out a first level of services to which the first subscriber subscribes to determine operating parameters for the first subscriber. The computing system receives a second set of input parameters from a second subscriber and carries out a second level of services to which the second subscriber subscribes to determine operating parameters for the second subscriber. The computing system then computes the operating set points based on aggregate operating parameters for the first and second subscribers.

Abstract: The present disclosure relates to a method and system of access management using a payment transaction. The computer-implemented method includes receiving a payment transaction request and one or more details associated with a lock. Further, the method includes providing one of a success message or a failure message to an access management system to operate the lock based on a result of authorization of the payment transaction request and a result of a validation of the one or more details.

Abstract: The present invention provides clinical evidence for a method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring myeloablative conditioning.

Abstract: According to the embodiments provided herein, a photovoltaic device can include a buffer layer adjacent to an absorber layer doped p-type with a group V dopant. The buffer layer can have a plurality of layers compatible with group V dopants.

Abstract: An electrical system for a wind turbine having a reduced uptower footprint and method for achieving the same are provided. Accordingly, the electrical system includes a plurality of electrical subsystems having a plurality of electrical subsystem assemblies. At least one electrical subsystem assembly is integrated with the generator housing. Additionally, the electrical subsystem assembly is coupled between the stator or the rotor of the generator and the generator output connection. The electrical system incorporating the electrical subsystem assembly with the generator housing has a reduced uptower footprint relative to a nominal design of an electrical system.