Patents by Inventor Rajnikant Patel
Rajnikant Patel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210393436Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.Type: ApplicationFiled: January 4, 2021Publication date: December 23, 2021Inventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
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Patent number: 10905586Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.Type: GrantFiled: March 23, 2020Date of Patent: February 2, 2021Assignees: Georgia Tech Research Corporation, Emory UniversityInventors: Mark Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
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Publication number: 20210022918Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.Type: ApplicationFiled: October 2, 2020Publication date: January 28, 2021Inventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
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Publication number: 20200237556Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.Type: ApplicationFiled: March 23, 2020Publication date: July 30, 2020Inventors: Mark Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
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Patent number: 10632013Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.Type: GrantFiled: September 19, 2017Date of Patent: April 28, 2020Assignees: GEORGIA TECH RESEARCH CORPORATION, EMORY UNIVERSITYInventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
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Publication number: 20190339279Abstract: Starch nanoparticles (SNPs) were fluorescently labeled with 1-pyrenebutyric acid and pyrene fluorescence was employed to detect nitrated organic compounds (NOCs) in solution and on paper surfaces. Fluorescence quenching of the pyrene-labeled SNPs (Py-SNPs) by NOCs such as nitromethane, nitrotoluene (MNT), dinitrotoluene (DNT), and trinitrotoluene (TNT) was characterized in DMSO and water. Since pyrene is insoluble in water, the fluorescence of the pyrene excimer that dominated the fluorescence spectrum of the Py-SNPs dispersed in water was used for the fluorescence quenching experiments. The efficient binding of the aromatic NOCs to the pyrene aggregates of Py-SNPs dispersed in water was used to detect NOCs by Py-SNPs adsorbed at the surface of paper sheets. The low quantities of aromatic NOCs detected by the Py-SNPs demonstrate the potential of Py-SNP-coated paper for the detection of such compounds.Type: ApplicationFiled: May 2, 2019Publication date: November 7, 2019Inventors: Jean DUHAMEL, Lu LI, Sanjay Rajnikant PATEL
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Publication number: 20180028357Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.Type: ApplicationFiled: September 19, 2017Publication date: February 1, 2018Inventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
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Patent number: 9788995Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.Type: GrantFiled: December 20, 2013Date of Patent: October 17, 2017Assignees: Georgia Tech Research Corporation, Emory UniversityInventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
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Publication number: 20140336599Abstract: A suction manifold assembly for a fluid management system comprised of a suction manifold and a mounting member. The suction manifold includes a single outlet port and a plurality of inlet ports, including a removable inlet port having a tissue collection device for collecting excised tissue. The suction manifold assembly enables convenient and precise adjustment of suction levels of inputs into fluid collection containers, integrates tissue collection with suction operations, and provides strain relief to tubing thereby allowing accurate fluid deficit monitoring operations.Type: ApplicationFiled: May 13, 2013Publication date: November 13, 2014Applicant: Thermedx, LLCInventors: Nilesh Rajnikant Patel, Douglas L. Carr
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Patent number: 8808225Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.Type: GrantFiled: April 15, 2012Date of Patent: August 19, 2014Assignees: Emory University, Georgia Tech Research CorporationInventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
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Publication number: 20140107566Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.Type: ApplicationFiled: December 20, 2013Publication date: April 17, 2014Applicants: Georgia Tech Research Corporation, Emory UniveristyInventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
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Patent number: 8636713Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.Type: GrantFiled: April 23, 2012Date of Patent: January 28, 2014Assignees: Emory University, Georgia Tech Research CorporationInventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
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Publication number: 20120232522Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.Type: ApplicationFiled: April 23, 2012Publication date: September 13, 2012Inventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
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Publication number: 20120226260Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.Type: ApplicationFiled: April 15, 2012Publication date: September 6, 2012Applicants: Georgia Tech Research Corporation, Emory UniversityInventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
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Patent number: 8197435Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.Type: GrantFiled: April 26, 2010Date of Patent: June 12, 2012Assignees: Emory University, Georgia Tech Research CorporationInventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
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Patent number: 8090676Abstract: Systems and methods (300) for offline/online performance monitoring of batch processes (BPs) involving obtaining archived data (AD) obtained during runs of BP and including information defining a batch quality attribute for each run. The method also involves forming clusters by classifying AD for the runs into classes based on the batch quality attribute(s) and building a first multivariate statistical model (MSM) using AD. The method can further involve building a wavelet analysis based feature matrix (FM) using AD, forming a first projection (1200) by projecting FM onto a first MSM, building a second MSM (1300) using information obtained from the first projection, and computing centroids (C902, . . . , C918) and boundary profiles for the clusters (902, . . . , 918). The method can involve performing an online/offline performance monitoring (700/800) using an integrated version of the first and second MSM, a classification algorithm, centroids, and boundary profiles.Type: GrantFiled: September 11, 2008Date of Patent: January 3, 2012Assignee: Honeywell International Inc.Inventors: Shailesh Rajnikant Patel, Ramprasad Yelchuru, Srikanth Ryali, Pradeep K. Shetty, Gudi Ravindra
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Patent number: 8078434Abstract: A method (300, 400, 500, 1200) for offline/online monitoring of batch processes. The method involves (312) decomposing a time domain of a batch process run (BPR) into several blocks and (334) building multivariate statistical models (MSMs) for each of them using archived data for a batch process (ABPD). ABPD comprises stored data obtained during BPRs. The method also involves (506, 1204) retrieving recently stored data (RSD) for a recent fully performed BPR run (FPRNEW) or current BPR run. The method further involves (520, 1210) building a feature vector matrix (FVM) using RSD. FVM contains feature vectors representing statistical measures of wavelet coefficients determined for variables (v0, . . . , vJ). A projection (1100, 1150, 1190) is formed by projecting feature vectors onto at least one MSM or a combined multivariate statistical model (CMSM). CMSM is a weighted average of at least two MSMs.Type: GrantFiled: July 17, 2008Date of Patent: December 13, 2011Assignee: Honeywell International Inc.Inventors: Ramprasad Yelchuru, Srikanth Ryali, Shailesh Rajnikant Patel, Gudi Ravindra
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Publication number: 20110046637Abstract: The present invention provides a sensorized medical instrument that is suitable for application to, and training and skills assessment for, a variety of therapeutic, diagnostic, surgical and medical procedures. It is comprised of a sterilizable sensorized instrument capable of measuring forces in five degrees of freedom and tip position in six degrees of freedom. The instrument can be used to perform a variety of tasks through the integration of interchangeable instrument tips and handles. The system is capable of providing feedback to the user regarding critical forces/torques acting on the tissue, position and orientation of the instrument and its tip near critical areas within the body, or user performance during training and skills evaluation.Type: ApplicationFiled: January 8, 2009Publication date: February 24, 2011Applicant: THE UNIVERSITY OF WESTERN ONTARIOInventors: Rajnikant Patel, Ana Luisa Trejos, Mahdi Tavakoli, Michael David Naish
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Publication number: 20100256597Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.Type: ApplicationFiled: April 26, 2010Publication date: October 7, 2010Applicants: EMORY UNIVERSITY, GEORGIA TECH RESEARCH CORPORATIONInventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
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Publication number: 20100063611Abstract: Systems and methods (300) for offline/online performance monitoring of batch processes (BPs) involving obtaining archived data (AD) obtained during runs of BP and including information defining a batch quality attribute for each run. The method also involves forming clusters by classifying AD for the runs into classes based on the batch quality attribute(s) and building a first multivariate statistical model (MSM) using AD. The method can further involve building a wavelet analysis based feature matrix (FM) using AD, forming a first projection (1200) by projecting FM onto a first MSM, building a second MSM (1300) using information obtained from the first projection, and computing centroids (C902, . . . , C918) and boundary profiles for the clusters (902, . . . , 918). The method can involve performing an online/offline performance monitoring (700/800) using an integrated version of the first and second MSM, a classification algorithm, centroids, and boundary profiles.Type: ApplicationFiled: September 11, 2008Publication date: March 11, 2010Inventors: Shailesh Rajnikant Patel, Ramprasad Yelchuru, Srikanth Ryali, Pradeep K. Shetty, Gudi Ravindra