Patents by Inventor Raju Bore Gowda

Raju Bore Gowda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperidine derivative and methods of use thereof
    Patent number: 10364233
    Abstract: The present invention provides N-[1-(1-Cyclohexyl-3,5-dimethyl-1H-pyrazole-4-sulfonyl)-4-phenyl-piperidin-4-ylmethyl]-N-isobutyl-4-{[(piperidin-4-ylmethyl)-amino]-methyl}-benzenesulfonamide and pharmaceutically acceptable salts thereof. These compounds may be useful in the treatment of diseases such as Alzheimer's disease or renal failure. The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds and/or pharmaceutical compositions in treating certain diseases.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: July 30, 2019
    Assignee: vTv Therapeutics LLC
    Inventors: Adnan M. M. Mjalli, Anitha Hari, Bapu Gaddam, Daniel P. Christen, Dharma Rao Polisetti, William Kenneth Banner, Raju Bore Gowda, Robert Carl Andrews, Suparna Gupta
  • Substituted imidazole derivatives and methods of use thereof
    Patent number: 10363241
    Abstract: The present invention provides intermediates for methods for synthesizing compounds of Formula (I) and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: July 30, 2019
    Assignee: vTv Therapeutics LLC
    Inventors: David Jones, Raju Bore Gowda, Rongyuan Xie
  • Substituted Imidazole Derivatives and Methods of Use Thereof
    Publication number: 20190076402
    Abstract: The present invention provides intermediates for methods for synthesizing compounds of Formula (I) and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: November 9, 2018
    Publication date: March 14, 2019
    Inventors: David Jones, Raju Bore Gowda, Rongyuan Xie
  • Piperidine Derivative and Methods of Use Thereof
    Publication number: 20180362505
    Abstract: The present invention provides N-[1-(1-Cyclohexyl-3,5-dimethyl-1H-pyrazole-4-sulfonyl)-4-phenyl-piperidin-4-ylmethyl]-N-isobutyl-4-{[(piperidin-4-ylmethyl)-amino]-methyl}-benzenesulfonamide and pharmaceutically acceptable salts thereof. These compounds may be useful in the treatment of diseases such as Alzheimer's disease or renal failure. The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds and/or pharmaceutical compositions in treating certain diseases.
    Type: Application
    Filed: August 22, 2018
    Publication date: December 20, 2018
    Inventors: Adnan M.M. Mjalli, Anitha Hari, Bapu Gaddam, Daniel P. Christen, Dharma Rao Polisetti, William Kenneth Banner, Raju Bore Gowda, Robert Carl Andrews, Suparna Gupta
  • Substituted Imidazole Derivatives and Methods of Use Thereof
    Publication number: 20170157093
    Abstract: The present invention provides imidazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof. and their use in the treatment of diseases.
    Type: Application
    Filed: February 21, 2017
    Publication date: June 8, 2017
    Inventors: David Jones, Raju Bore Gowda, Rongyuan Xie
  • Substituted imidazole derivatives and methods of use thereof
    Patent number: 9598375
    Abstract: The present invention provides imidazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof. and their use in the treatment of diseases such as Alzheimer's Disease.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: March 21, 2017
    Assignee: vTv Therapeutics LLC
    Inventors: David Jones, Raju Bore Gowda, Rongyuan Xie
  • Substituted Imidazole Derivatives and Methods of Use Thereof
    Publication number: 20140039025
    Abstract: The present invention provides imidazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof. and their use in the treatment of diseases such as Alzheimer's Disease.
    Type: Application
    Filed: October 9, 2013
    Publication date: February 6, 2014
    Applicant: TransTech Pharma, Inc.
    Inventors: David Jones, Raju Bore Gowda, Rongyuan Xie
  • Substituted imidazole derivatives and methods of use thereof
    Patent number: 8580833
    Abstract: The present invention provides imidazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment of RAGE-mediated diseases such as Alzheimer's Disease. The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use the such compounds and/or pharmaceutical compositions in treating RAGE-mediated diseases.
    Type: Grant
    Filed: September 23, 2010
    Date of Patent: November 12, 2013
    Assignee: TransTech Pharma, Inc.
    Inventors: David Jones, Raju Bore Gowda, Rongyuan Xie
  • Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as ?-secretase inhibitors
    Patent number: 8450354
    Abstract: The present invention provides substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutically acceptable salts thereof, and tautomers of any of the foregoing, where such compounds inhibit ?-site amyloid precursor protein-cleaving enzyme (BACE), which may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention also provides pharmaceutical compositions comprising any of these compounds and the use of any of these compounds and compositions in the treatment of diseases, disorders, or conditions in which BACE is involved.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: May 28, 2013
    Assignee: High Point Pharmaceuticals, LLC
    Inventors: Adnan M. M. Mjalli, Anitha Hari, Bapu Gaddam, Devi Reddy Gohimukkula, Dharma Rao Polisetti, Mohan Rao, Raju Bore Gowda, Robert Carl Andrews, Rongyuan Xie, Soumya P. Sahoo, Tan Ren, William Kenneth Banner
  • SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS
    Publication number: 20110237570
    Abstract: The present invention provides substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutically acceptable salts thereof, and tautomers of any of the foregoing, where such compounds inhibit ?-site amyloid precursor protein-cleaving enzyme (BACE), which may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention also provides pharmaceutical compositions comprising any of these compounds and the use of any of these compounds and compositions in the treatment of diseases, disorders, or conditions in which BACE is involved.
    Type: Application
    Filed: March 21, 2011
    Publication date: September 29, 2011
    Applicant: HIGH POINT PHARMACEUTICALS, LLC
    Inventors: Adnan M.M. Mjalli, Anitha Hari, Bapu Gaddam, Devi Reddy Gohimukkula, Dharma Rao Polisetti, Mohan Rao, Raju Bore Gowda, Robert Carl Andrews, Rongyuan Xie, Soumya P. Sahoo, Tan Ren, William Kenneth Banner
  • Substituted Imidazole Derivatives And Methods Of Use Thereof
    Publication number: 20110105578
    Abstract: The present invention provides imidazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment of RAGE-mediated diseases such as Alzheimer's Disease. The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use the such compounds and/or pharmaceutical compositions in treating RAGE-mediated diseases.
    Type: Application
    Filed: September 23, 2010
    Publication date: May 5, 2011
    Inventors: David Jones, Raju Bore Gowda, Rongyuan Xie