Patents by Inventor Raju Penmasta

Raju Penmasta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for stereoselective synthesis of prostacyclin derivatives
    Publication number: 20020087025
    Abstract: An improved method is described for making 9-deoxy-PGF1-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Application
    Filed: February 15, 2002
    Publication date: July 4, 2002
    Applicant: UNITED THERAPEUTICS CORPORATION
    Inventors: Robert M. Moriarty, Raju Penmasta, Liang Guo, Munagala S. Rao, James P. Staszewski
  • Methods for preparation and use of 1&agr;,24(S)-dihydroxy vitamin D2
    Patent number: 6251883
    Abstract: 1&agr;,24(S)-Dihydroxy vitamin D2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1&agr;,24(S)-dihydroxy vitamin D2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D2 which is converted in six steps to 1&agr;,24(S)-dihydroxy vitamin D2. The syntheses also produced novel intermediates.
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: June 26, 2001
    Assignee: Bone Care International, Inc.
    Inventors: Ronald L. Horst, Charles W. Bishop, Glenville Jones, Nicholas J. Koszewski, Joyce C. Knutson, Robert M. Moriarty, Timothy Reinhardt, Raju Penmasta, Stephen Strugnell, Liang Guo, Sanjay K. Singhal, Lei Zhao
  • Methods for preparation and use of 1&agr;,24 (S)-dihydroxy vitamin D2
    Patent number: 6211168
    Abstract: 1&agr;,24(S)-Dihydroxy vitamin D2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1&agr;,24(S)-dihydroxy vitamin D2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D2 which is converted in six steps to 1&agr;,24(S)-dihydroxy vitamin D2. The syntheses also produced novel intermediates.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 3, 2001
    Assignees: Bone Care International, Inc, The United States of America as represented by the Secretary of Agriculture
    Inventors: Charles W. Bishop, Ronald L. Horst, Glenville Jones, Nicholas J. Koszewski, Joyce C. Knutson, Robert M. Moriarty, Timothy A. Reinhardt, Raju Penmasta, Stephen Strugnell, Liang Guo, Sanjay K. Singhal, Lei Zhao
  • Methods for preparation and use of 1.alpha., 24(S) -dihydroxy vitamin D2
    Patent number: 6143910
    Abstract: 1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: November 7, 2000
    Assignees: Bone Care International, Inc., The United States of America as represented by the Secretary of Agriculture
    Inventors: Charles W. Bishop, Ronald L. Horst, Glenville Jones, Nicholas J. Koszewski, Joyce C. Knutson, Robert M. Moriarty, Timothy A. Reinhardt, Raju Penmasta, Stephen Strugnell, Liang Guo, Sanjay K. Singhal, Lei Zhao
  • Synthesis of 1.alpha.-hydroxy vitamin D
    Patent number: 5869472
    Abstract: A method for 1.alpha.-hydroxylation of vitamin D compounds using the appropriate vitamin D as the starting material. The method requires no separatory procedures prior to the actual hydroxylation step.
    Type: Grant
    Filed: April 17, 1997
    Date of Patent: February 9, 1999
    Assignee: Bone Care International, Inc.
    Inventors: Robert M. Moriarty, Liang Guo, Raju A. Penmasta
  • Methods for preparation and use of 1A,24(S)-dihydroxy vitamin D2
    Patent number: 5789397
    Abstract: 1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 4, 1998
    Assignee: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Glenville Jones, Ronald L. Horst, Nicholas J. Koszewski, Joyce C. Knutson, Raju Penmasta, Robert M. Moriarty, Stephen Strugnell, Timothy A. Reinhardt, Liang Guo, Sanjay K. Singhal, Lei Zhao
  • Methods for preparation and use of 1.alpha.,24(S)-dihydroxy vitamin D.sub.2
    Patent number: 5786348
    Abstract: 1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 28, 1998
    Assignee: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Ronald L. Horst, Glenville Jones, Nicholas J. Koszewski, Joyce C. Knutson, Robert M. Moriarty, Timothy A. Reinhardt, Raju Penmasta, Stephen Strugnell, Liang Guo, Sanjay K. Singhal, Lei Zhao
  • 1.alpha.-Hydroxy-24-EPI-vitamin D.sub.4
    Patent number: 5756783
    Abstract: 1.alpha.-Hydroxy-24-epi-vitamin D.sub.4 and novel intermediates formed in a novel method of preparing this compound. The method includes campesterol as a starting material which is converted to 24-epi-vitamin D.sub.4 which is in turn hydroxylated to 1.alpha.-hydroxy-24-epi-vitamin D.sub.4 via tosylated and cyclic derivatives of 24-epi-vitamin D.sub.4. 1.alpha.-Hydroxy-24-epi-vitamin D.sub.4 has been found to be bioactive.
    Type: Grant
    Filed: September 7, 1995
    Date of Patent: May 26, 1998
    Assignee: Bone Care International, Inc.
    Inventors: Joyce C. Knutson, Robert M. Moriarty, Raju Penmasta, Charles W. Bishop