Patents by Inventor Raju Penmasta

Raju Penmasta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6211168
    Abstract: 1&agr;,24(S)-Dihydroxy vitamin D2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1&agr;,24(S)-dihydroxy vitamin D2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D2 which is converted in six steps to 1&agr;,24(S)-dihydroxy vitamin D2. The syntheses also produced novel intermediates.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 3, 2001
    Assignees: Bone Care International, Inc, The United States of America as represented by the Secretary of Agriculture
    Inventors: Charles W. Bishop, Ronald L. Horst, Glenville Jones, Nicholas J. Koszewski, Joyce C. Knutson, Robert M. Moriarty, Timothy A. Reinhardt, Raju Penmasta, Stephen Strugnell, Liang Guo, Sanjay K. Singhal, Lei Zhao
  • Patent number: 6143910
    Abstract: 1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: November 7, 2000
    Assignees: Bone Care International, Inc., The United States of America as represented by the Secretary of Agriculture
    Inventors: Charles W. Bishop, Ronald L. Horst, Glenville Jones, Nicholas J. Koszewski, Joyce C. Knutson, Robert M. Moriarty, Timothy A. Reinhardt, Raju Penmasta, Stephen Strugnell, Liang Guo, Sanjay K. Singhal, Lei Zhao
  • Patent number: 5869472
    Abstract: A method for 1.alpha.-hydroxylation of vitamin D compounds using the appropriate vitamin D as the starting material. The method requires no separatory procedures prior to the actual hydroxylation step.
    Type: Grant
    Filed: April 17, 1997
    Date of Patent: February 9, 1999
    Assignee: Bone Care International, Inc.
    Inventors: Robert M. Moriarty, Liang Guo, Raju A. Penmasta
  • Patent number: 5789397
    Abstract: 1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 4, 1998
    Assignee: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Glenville Jones, Ronald L. Horst, Nicholas J. Koszewski, Joyce C. Knutson, Raju Penmasta, Robert M. Moriarty, Stephen Strugnell, Timothy A. Reinhardt, Liang Guo, Sanjay K. Singhal, Lei Zhao
  • Patent number: 5786348
    Abstract: 1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 28, 1998
    Assignee: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Ronald L. Horst, Glenville Jones, Nicholas J. Koszewski, Joyce C. Knutson, Robert M. Moriarty, Timothy A. Reinhardt, Raju Penmasta, Stephen Strugnell, Liang Guo, Sanjay K. Singhal, Lei Zhao
  • Patent number: 5756783
    Abstract: 1.alpha.-Hydroxy-24-epi-vitamin D.sub.4 and novel intermediates formed in a novel method of preparing this compound. The method includes campesterol as a starting material which is converted to 24-epi-vitamin D.sub.4 which is in turn hydroxylated to 1.alpha.-hydroxy-24-epi-vitamin D.sub.4 via tosylated and cyclic derivatives of 24-epi-vitamin D.sub.4. 1.alpha.-Hydroxy-24-epi-vitamin D.sub.4 has been found to be bioactive.
    Type: Grant
    Filed: September 7, 1995
    Date of Patent: May 26, 1998
    Assignee: Bone Care International, Inc.
    Inventors: Joyce C. Knutson, Robert M. Moriarty, Raju Penmasta, Charles W. Bishop