Abstract: The aerosol box for protection during aerosol-generating procedures is an enclosure for a patient's head and neck. The aerosol box includes a floor formed from at least one flexible sheet. The aerosol box further includes a top defining a central viewing window and a body sealed to the top and the floor. The body is configured as the frustum of a right, regular polygonal enclosure having a plurality of wall panels made of flexible resilient material and may be at least partially transparent. The wall panels are sealed to the top and floor, and one of the wall panels defines a patient entryway for introducing the patient's head and neck into the sealed enclosure. The wall panels include sleeve-and-glove assemblies extending into the enclosure for use by a primary health care worker and a plurality of assistants. The aerosol box is made of material impermeable to contaminants borne by aerosols.