Patents by Inventor Rakefet Rosenfeld

Rakefet Rosenfeld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD AND ASSAY FOR GLYCOSYLATION PATTERN DETECTION RELATED TO CELL STATE OF STEM CELLS
    Publication number: 20130315881
    Abstract: A method and assay for characterizing populations of stem cells according to their glycosylation pattern, particularly for distinguishing between stem cell populations, for example with regard to state of differentiation.
    Type: Application
    Filed: April 23, 2013
    Publication date: November 28, 2013
    Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD., Procognia (Israel) Ltd.
    Inventors: Dov ZIPORI, Vered MORAD, Rakefet ROSENFELD, Albena SAMOKOVLISKY, Yeshayahu YAKIR, Dorit LANDSTEIN, Noa ZALLE, Ronny ALONI
  • Method and Assay for Glycosylation Pattern Detection Related to Cell State
    Publication number: 20120165206
    Abstract: A method and assay for characterizing populations of cells according to their glycosylation pattern, particularly for distinguishing between cell populations. In preferred embodiments the present invention is able to determine the state of a stem cell (ie differentiated or undifferentiated) and/or the state of a cancer cell, for example with regard to malignancy. Preferably the present invention is also able to determine whether a patient is likely to respond to a drug according to the glycosylation pattern of a sample of cancer cells taken from the patient (or alternatively examined while in the patient, as described in greater detail below). Also optionally, it may be used to analyze a cell population before and after treatment with a drug for example.
    Type: Application
    Filed: July 11, 2007
    Publication date: June 28, 2012
    Inventors: Rakefet Rosenfeld, Noa Zalle, Dorit Landstein, Albena Samokovlisky, Ronny Aloni, Ruth Maya, Yeshayahu Yakir
  • DIAGNOSIS OF CANCERS THROUGH GLYCOME ANALYSIS
    Publication number: 20120165221
    Abstract: Markers and methods of diagnosis and monitoring of cancer through global glycome analysis.
    Type: Application
    Filed: September 7, 2010
    Publication date: June 28, 2012
    Inventors: Dorit Landstein, Allbena Samokovlisky, Boris Gorelik, Ilana Belzer, Mor Goldenberg-, Oshry Biton, Rakefet Rosenfeld, Shoshy Mizrahy, Yeshayahu Yakir
  • Method for analyzing a glycomolecule
    Patent number: 8119357
    Abstract: The invention relates generally the structural analysis of glycomolecule-containing macromolecules, such as those that occur either attached to proteins (proteoglycans, glycoproteins), lipids, or as free saccharides.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: February 21, 2012
    Assignee: Procognia, Ltd.
    Inventors: Yehudit Amor, Ofer Markman, Mirit Kolog Gulko, Albena Samokovlisky, Fredi Kleinman, Tal Alergand, Rakefet Rosenfeld, Ruth Maya, Sabina Rebe, Idil Kelson Kasuto, Haim Bangio
  • Method for Analyzing a Glycomolecule
    Publication number: 20110021376
    Abstract: The invention relates generally the structural analysis of glycomolecule-containing macromolecules, such as those that occur either attached to proteins (proteoglycans, glycoproteins), lipids, or as free saccharides.
    Type: Application
    Filed: September 30, 2010
    Publication date: January 27, 2011
    Applicant: Procognia, Ltd.
    Inventors: Yehudit Amor, Ofer Markman, Mirit Kolog Gulko, Albena Samokovlisky, Fredi Kleinman, Tal Alergand, Rakefet Rosenfeld, Ruth Maya, Sabina Rebe, Idil Kelson Kasuto, Haim Bangio
  • Method for analyzing a glycomolecule
    Publication number: 20050186645
    Abstract: The invention relates generally the structural analysis of glycomolecule-containing macromolecules, such as those that occur either attached to proteins (proteoglycans, glycoproteins), lipids, or as free saccharides.
    Type: Application
    Filed: December 20, 2004
    Publication date: August 25, 2005
    Inventors: Yehudit Amor, Ofer Markman, Mirit Gulko, Albena Samokovlisky, Fredi Kleinman, Tal Alergand, Rakefet Rosenfeld, Ruth Maya, Sabina Rebe, Idil Kasuto, Haim Bangio
  • Identifying pharmacophore containing combinations of scaffold molecules and substituents from a virtual library
    Patent number: 6343257
    Abstract: A method for constructing a potentially pharmaceutically useful molecule that displays a predefined pharmacophore associated with a desired biological activity is disclosed. The pharmacophore is first used to screen a virtual library of scaffolds, described by three-dimensional coordinates, in order to identify one or more scaffold(s) which could potentially display substituents that alone or together with scaffold atoms comprise a pharmacophore. The screening process involves first placing rotamers from a virtual library of substituents onto each attachment point of each scaffold, and then examining the resultant Virtual Combinatorial Library (VCL) according to one or more parameters required by the pharmacophore.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: January 29, 2002
    Assignee: Peptor Ltd.
    Inventors: Roberto Olender, Rakefet Rosenfeld
  • General strategy for vaccine and drug design
    Patent number: 5495423
    Abstract: A method for computing the conformation and location that a protein fragment will obtain in binding to the active site of a receptor is provided. The invention relates to both the computation of conformation and location of natural ligands within an active site and the design of artificial ligands with useful binding characteristics.
    Type: Grant
    Filed: October 25, 1993
    Date of Patent: February 27, 1996
    Assignee: Trustees of Boston University
    Inventors: Charles DeLisi, James L. Cornette, Ugur Sezerman, Rakefet Rosenfeld, Sandor Vajda