Patents by Inventor Rakesh Anand

Rakesh Anand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods
    Publication number: 20030223986
    Abstract: This invention relates to polymorphisms in the human pyruvate dehydrogenase complex E2 (PDH E2 or PDC E2) gene and corresponding novel allelic polypeptides encoded thereby. The invention also relates to methods and materials for analysing allelic variation in the PDH E2 gene, and to the use of PDH E2 polymorphism in the diagnosis and treatment of. diseases in which modulation of pyruvate dehydrogenase activity could be of therapeutic benefit, such as diabetes, asthma, obesity, sepsis and peripheral vascular disease. In particular, the invention is based on the discovery of two single nucleotide polymorphisms (SNPs) in the coding region of the human PDH E2 gene.
    Type: Application
    Filed: March 27, 2003
    Publication date: December 4, 2003
    Applicant: AstraZeneca AB, a Swedish corporation
    Inventors: John C. Smith, Rakesh Anand, John E.N. Morten
  • Methods
    Publication number: 20030190607
    Abstract: This invention relates to polymorphisms in the human pyruvate dehydrogenase E1&bgr; (PDH E1&bgr;) gene. The invention also relates to methods and materials for analysing allelic variation in the PDH E1&bgr; gene, and to the use of PDH E1&bgr; polymorphism in the diagnosis and treatment of diseases in which modulation of pyruvate dehydrogenase activity could be of therapeutic benefit, such as diabetes, asthma, obesity, sepsis and peripheral vascular disease. In particular, the invention is based on the discovery of a single nucleotide polymorphism in the coding region of the human PDH E1&bgr; gene, and three single nucleotide polymorphisms in the 3′ untranslated region (3′UTR) of the human PDH E1&bgr; gene.
    Type: Application
    Filed: January 18, 2001
    Publication date: October 9, 2003
    Inventors: John C. Smith, Rakesh Anand, John E.N. Morten
  • Methods
    Publication number: 20020143162
    Abstract: This invention relates to polymorphisms and novel sequence in the human pyruvate dehydrogenase E1&agr; (PDH E1&agr;) gene. The invention also relates to methods and materials for analysing allelic variation in the PDH E1&agr; gene, and to the use of PDH E1&agr; polymorphism in the diagnosis and treatment of diseases in which modulation of pyruvate dehydrogenase activity could be of therapeutic benefit, such as diabetes, asthma, obesity, sepsis and peripheral vascular disease. In particular, the invention is based on the discovery of a nucleotide polymorphism in the 3′ untranslated region (3′UTR) of the human PDH E1&agr; gene. In addition, we disclose the sequence of intron 7 of the human PDH E1&agr; gene and identify two polymorphisms within intron 7.
    Type: Application
    Filed: January 18, 2001
    Publication date: October 3, 2002
    Inventors: John Smith, Rakesh Anand, John En Morten
  • Diagnosis for mutant APC by immunoassay
    Patent number: 6413727
    Abstract: A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: July 2, 2002
    Assignees: The Johns Hopkins University, University of Utah, Japanese Foundation for Cancer Research Cancer Institute, Zeneca Limited
    Inventors: Hans Albertsen, Rakesh Anand, Mary Carlson, Joanna Groden, Philip John Hedge, Geoff Joslyn, Kenneth Kinzler, Alexander Fred Markham, Yusuke Nakamura, Andrew Thliveris, Bert Vogelstein, Raymond L. White
  • Methods
    Publication number: 20020076702
    Abstract: This invention relates to polymorphisms in the human prostaglandin E2 receptor 1 (EP1-R) gene and corresponding novel allelic polypeptides encoded thereby. Fourteen specific polymorphisms are identified. The invention also relates to methods and materials for analysing allelic variation in the EP1-R gene and to the use of said polymorphism in the diagnosis and treatment of EP1-R ligand mediated diseases, such as cancer or arthritis.
    Type: Application
    Filed: February 13, 2001
    Publication date: June 20, 2002
    Inventors: Rakesh Anand, John C. Smith, John E. N. Morten
  • Detection of APC proteins
    Patent number: 6114124
    Abstract: A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: September 5, 2000
    Assignees: The Johns Hopkins University, University of Utah, The Cancer Institute, Imperial Chemical Industries PLC
    Inventors: Hans Albertsen, Rakesh Anand, Mary Carlson, Joanna Groden, Philip John Hedge, Geoff Joslyn, Kenneth Kinzler, Alexander Fred Markham, Yusuke Nakamura, Andrew Thliveris, Bert Vogelstein, Raymond L. White
  • Yeast artificial chromosomes containing DNA encoding the cystic fibrosis (CFTR) gene
    Patent number: 5939255
    Abstract: Yeast Artificial Chromosomes (YACS) containing DNA encoding the cystic fibrosis (CFTR) gene are described. The YACs allow detailed analysis of the coding and non-coding regions of the gene and the determination of cystic fibrosis alleles in sample DNA from an individual or individuals.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: August 17, 1999
    Assignee: Zeneca Limited
    Inventors: Rakesh Anand, Alexander Fred Markham, John Craig Smith, Rashida Anwar, John Hamilton Riley, Donald James Ogilvie, Paul Elvin
  • APC (adenomatous polyosis coli) protein
    Patent number: 5783666
    Abstract: A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: July 21, 1998
    Assignees: The Johns Hopkins University, The University of Utah, Zeneca Pharmaceuticals, The Cancer Institute
    Inventors: Hans Albertsen, Rakesh Anand, Mary Carlson, Joanna Groden, Philip John Hedge, Geoff Joslyn, Kenneth Kinzler, Alexander Fred Markham, Yusuke Nakamura, Andrew Thliveris, Bert Vogelstein, Raymond L. White
  • APC antibodies
    Patent number: 5691454
    Abstract: A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: November 25, 1997
    Assignees: The Johns Hopkins University, University of Utah, the Cancer Institute, Imperial Chemical Industries PLC
    Inventors: Hans Albertsen, Rakesh Anand, Mary Carlson, Joanna Groden, Philip John Hedge, Geoff Joslyn, Kenneth Kinzler, Alexander Fred Markham, Yusuke Nakamura, Andrew Thliveris, Bert Vogelstein, Raymond L. White
  • Detection of inherited and somatic mutations of APC gene in colorectal cancer of humans
    Patent number: 5648212
    Abstract: Methods are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. APC is a tumor suppressor.
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: July 15, 1997
    Assignees: The John Hopkins University, University of Utah, Japanese Foundation for Cancer Research Cancer Institute, Zeneca Limited
    Inventors: Hans Albertsen, Rakesh Anand, Mary Carlson, Joanna Groden, Philip John Hedge, Geoff Joslyn, Kenneth Kinzler, Alexander Markham, Yusuke Nakamura, Andrew Thliveris, Bert Vogelstein, Raymond L. White
  • Nucleotide sequences
    Patent number: 5525467
    Abstract: Yeast artificial chromosomes (YACs), nucleotide sequences and polypeptides derived therefrom. Their use in methods for the detection, diagnosis and therapy of Alzheimer's disease. Their use in the preparation of transfected cells and transgenic animals. Diagnostic kits for use in the methods of the invention.
    Type: Grant
    Filed: June 7, 1994
    Date of Patent: June 11, 1996
    Assignee: Imperial Chemical Industries PLC
    Inventor: Rakesh Anand
  • APC gene and nucleic acid probes derived therefrom
    Patent number: 5352775
    Abstract: A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
    Type: Grant
    Filed: August 8, 1991
    Date of Patent: October 4, 1994
    Assignees: The Johns Hopkins Univ., The Univ. of Utah, Imperial Chemical Industries, Cancer Institute
    Inventors: Hans Albertsen, Rakesh Anand, Mary Carlson, Joanna Groden, Philip J. Hedge, Geoff Joslyn, Kenneth Kinzler, Alexander F. Markham, Yusuke Nakamura, Andrew Thliveris, Bert Vogelstein, Raymond L. White
  • APC Antibodies
    Patent number: RE38916
    Abstract: A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: December 6, 2005
    Assignees: The Johns Hopkins University, The University of Utah, The Cancer Institute, Zeneca Limited
    Inventors: Bert Vogelstein, Kenneth W. Kinzler, Hans Albertsen, Rakesh Anand, Mary Carlson, Joanna Groden, Philip John Hedge, Geoff Joslyn, Alexander Fred Markham, Yusuka Nakamura, Andrew Thilveris, Raymond L. White
  • APC antibodies
    Patent number: RE40948
    Abstract: A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: October 27, 2009
    Assignees: The Johns Hopkins University, Astrazeneca United Kingdom, Ltd., Cancer Institute, Japanese, Foundation for Cancer Research, The University of Utah
    Inventors: Bert Vogelstein, Kenneth W. Kinzler, Hans Albertsen, Rakesh Anand, Mary Carlson, Joanna Groden, Philip Hedge, Geoff Joslyn, Alexander Fred Markham, Yusuke Nakumura, Andrew Thliveris, Raymond White
  • APC gene and nucleic acid probes derived therefrom
    Patent number: RE36713
    Abstract: A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in hum tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as wel as in sporadic colorectal cancer patents. APC is expressed in most normal tissue. These results suggest that APC is a tumor suppressor.
    Type: Grant
    Filed: October 4, 1996
    Date of Patent: May 23, 2000
    Assignees: The Johns Hopkins University, The University of Utah, Zeneca, Cancer Institute
    Inventors: Bert Vogelstein, Kenneth W. Kinzler, Hans Albertson, Rakesh Anand, Mary Carlson, Joanna Groden, Philip John Hedge, Geoff Joslyn, Alexander Fred Markham, Yusuke Nakamura, Andrew Thliveris, Raymond White