Abstract: A novel combination comprising a 17 ?-hydroxylase/C17,20 lyase inhibitor, for example: (3?)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol or a pharmaceutically acceptable salt or ester thereof, and an AKT inhibitor, for example: N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, and optional additional antineoplastic agents; pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of 17 ?-hydroxylase/C17,20 lyase and/or AKT inhibition is beneficial, e.g., cancer.

Abstract: An immunogenic composition comprising of Diphtheria toxoid antigen (D), tetanus toxoid (T) antigen, Hepatitis B surface antigen (HBsAg), inactivated whole-cell B. pertussis (wP) antigen, Haemophilus influenzae type B (Hib) capsular saccharide conjugated to a carrier protein, Inactivated Polio Virus (IPV) antigen and additionally one or more antigens and the method of preparing the same. A fully liquid combination vaccine, showing improved immunogenicity, reduced reactogenicity and improved stability. Improved methods of formaldehyde inactivation, improved adsorption profile of Diphtheria toxoid antigen (D), tetanus toxoid (T) antigen and Hepatitis B (HepB) surface antigen adsorbed individually onto aluminium phosphate adjuvant, minimum total aluminum content (Al3+) and optimized concentration of 2-phenoxyethanol (2-PE) as preservative.

Abstract: A microelectromechanical systems (MEMS) package may include a wafer having a MEMS device; a metal cap partially anchored to the wafer where at least one point between the cap and the wafer is unanchored, the metal cap at least substantially extending over the MEMS device; an electrical contact pad electrically coupled to the MEMS device; and a sealing layer disposed over the metal cap and the wafer, such that the sealing layer seals a gap between an unanchored portion of the metal cap and the wafer to encapsulate the MEMS device; wherein the electrical contact pad and the metal cap include the same composition.

Abstract: A method for providing a real time, three-dimensional (3D) navigational map for platforms includes integrating at least two sources of multi-modal and multi-dimensional platform sensor information to produce a more accurate 3D navigational map. The method receives both a 3D point cloud from a first sensor on a platform with a first modality and a 2D image from a second sensor on the platform with a second modality different from the first modality, generates a semantic label and a semantic label uncertainty associated with a first space point in the 3D point cloud, generates a semantic label and a semantic label uncertainty associated with a second space point in the 2D image, and fuses the first space semantic label and the first space semantic uncertainty with the second space semantic label and the second space semantic label uncertainty to create fused 3D spatial information to enhance the 3D navigational map.

Abstract: A MEMS device may include a first electrode region; a first piezoelectric layer arranged over the first electrode region; a second electrode region arranged over the first piezoelectric layer; a second piezoelectric layer arranged over the first piezoelectric layer and the second electrode region; a third electrode region arranged over the second piezoelectric layer; a first input port coupled to the first electrode region and/or the second electrode region for providing a first electrical signal to the first piezoelectric layer to generate a first vibration in the first piezoelectric layer; a second input port coupled to the second electrode region and/or the third electrode region for providing a second electrical signal to the second piezoelectric layer to generate a second vibration in the second piezoelectric layer; and an output port configured to receive an output signal including a superposition of the first vibration and the second vibration.

Abstract: A method for tailoring a bespoke processor includes generating first gate-level activity information of a general purpose processor design for all possible executions of a first target application for any possible inputs to the first target application. The method includes gate cutting and stitching based on the first gate-level activity information to remove unusable gates from the general purpose processor design and reconnect cut connections between the remaining gates of the general purpose processor design to generate a bespoke processor design for the first target application.

Abstract: According to various embodiments, a PMUT device may include a wafer, an active layer including a piezoelectric stack, an intermediate layer having a cavity therein where the intermediate layer is disposed between the wafer and the active layer such that the cavity is adjoining the piezoelectric stack. A via may be formed through the active layer and the intermediate layer to the wafer. A metallic layer may be disposed over the active layer and over surfaces of the via. The intermediate layer may include an interposing material surrounding the cavity, and may further include a sacrificial material surrounding the via. The sacrificial material may be different from the interposing material. The metallic layer may include a first member at least substantially overlapping the piezoelectric stack, a second member extending from the first member to the cavity, and a third member extending into the active layer to contact an electrode therein.

Abstract: A device may receive policy information associated with a first application group and a second application group. The device may receive network topology information associated with a network. The device may generate a first policy based on the policy information and the network topology information, and generate a second policy based on the policy information and the network topology information. The device may provide, to the virtual network device, information associated with the first policy to permit the virtual network device to implement the first policy in association with network traffic transferred between the first application group and the second application group. The device may provide, to the physical network device, information associated with the second policy to permit the physical network device to implement the second policy in association with network traffic transferred between the first application group and the second application group.

Abstract: A virtual server includes one or more processors that execute instructions to generate a virtual desktop, and generate an active virtual monitor and a paused virtual monitor for the generated virtual desktop. A first portion of the generated virtual desktop is assigned to the active virtual monitor, and a second portion of the generated virtual desktop is assigned to the paused virtual monitor. The active and paused virtual monitors each have a respective allocated memory. The amount of memory allocated for the paused virtual monitor is less than the amount of memory allocated for the active virtual monitor. A captured image of at least one of the first and second portions of the generated virtual desktop is provided for presenting on a physical monitor of a client device.

Abstract: A system for producing an audio file comprises a non-transitory computer-readable medium with instructions stored thereon, that when executed by a processor perform the steps of converting an additive manufacturing design file to a text-based file, converting the text-based file to a series of binary values, converting the series of binary values to a series of integers, calculating a normalization factor for the series of integers, dividing each of the series of integers by the normalizing factor to produce an array of floating point numbers known as the design string, multiplying the design string with the normalizing factor and comparing the resulting arrays with the original array of integers to generate the error string, converting the design string to an audio file, and converting the normalizing factor and the error string to a text file. Systems for verifying the authenticity of, identifying, and compressing AM design files are also described.

Abstract: Certain aspects of the present disclosure provide methods and apparatus for generating a negative boost voltage for memory write operations. One example memory circuit generally includes at least one memory bank, a write circuit coupled to the at least one memory bank, and a boost generation circuit coupled to the write circuit. The boost generation circuit generally includes a first node coupled to a reference potential node of the write circuit; a second node; a first capacitive element having a first terminal coupled to the first node of the boost generation circuit; a first switch configured to selectively couple the first node to a reference potential node for the memory circuit; and a second switch configured to selectively couple a second terminal of the first capacitive element to the second node of the boost generation circuit.

Abstract: Exemplary embodiments of the present disclosure are related to a cloud-based system in which portable electronic devices communicate with computing systems to implement one or more actions or operations for verifying authenticity of a physical object. Embodiments of the cloud-based product authentication system can include the portable electronic devices, an identification generating device, and a computing system connected to a cloud environment.

Abstract: Certain aspects of the present disclosure provide methods and apparatus for generating a negative boost voltage for memory write operations. One example memory circuit generally includes at least one memory bank, a write circuit coupled to the at least one memory bank, and a boost generation circuit coupled to the write circuit. The boost generation circuit generally includes a first node coupled to a reference potential node of the write circuit; a second node; a first capacitive element having a first terminal coupled to the first node of the boost generation circuit; a first switch configured to selectively couple the first node to a reference potential node for the memory circuit; and a second switch configured to selectively couple a second terminal of the first capacitive element to the second node of the boost generation circuit.

Abstract: Dynamically generating proxy virtual machines (VMs) in a virtual center (vCenter) serving a backup server, by deploying a source proxy VM by passing network data to the vCenter, passing a set of internet protocol (IP) addresses and network configuration information to the vCenter to be used by the dynamically generated proxy VMs, receiving an indication from the backup server that new proxy VMs are required, and performing, in the vCenter, an instant clone operation to spawn one or more new proxy VMs. The method may further comprise passing the IP address and network configuration information for the new proxy VMs to the backup server for registration within the backup server, and using the new proxy VMs for backup operations of the backup server.

Abstract: Aspects include computing devices, apparatus, and methods implemented by the apparatus for implementing multiple split snoop directories on a computing device having any number of processors, any number of power domains, and any number of processor caches. For example, various aspects may include enabling a first split snoop directory for a first power domain and a second split snoop directory for a second power domain, wherein the first power domain includes a first plurality of processor caches and the second power domain includes at least one processor cache, determining whether all of the first plurality of processor caches are in a low power state, and disabling the first split snoop directory in response to determining that the first plurality of processor caches are in a low power state. Similar operations may be performed for N number of power domains and M number of processor caches.

Abstract: This invention relates to a dispenser device for and a method of applying a structural adhesive to an application surface on a wind turbine blade structure, wherein the dispenser device comprises a housing forming a reservoir configured to hold a surplus of structural adhesive during dispensing. The reservoir is connected to an inlet for supplying the structural adhesive and an outlet for dispensing the structural adhesive. The outlet may be a side opening arranged in an exchangeable housing part. The dispenser device may also comprise an adjustable mechanism connected to a plate member configured to be moved relative to the side opening. The operation of the adjustable mechanism is controlled via a control unit or a control element. The exchangeable housing part or adjustable mechanism enables the cross-sectional profile, the width and/or the height of the dispensed structural adhesive to be changed before or during dispensing.

Abstract: The present invention relates to a novel and distinct cultivar of Perilla frutescens designated as ‘CAP HEMA’ The new cultivar is rich in omega-3 and having high seed and fatty oil yield. A method for producing new cultivar of Perilla frutescens plant which comprises selection of half-sib family from wild type populations. The method further comprises evaluation for the yield attributing characters of selected strains in field conditions. The genotype produced is distinct, uniform and stably maintained by continuous rouging of off types in the population at early seedling stage from nursery itself and suitable for commercial cultivation.

Abstract: A method and apparatus for training and guiding users comprising generating a scene understanding based on video and audio input of a scene of a user performing a task in the scene, correlating the scene understanding with a knowledge base to produce a task understanding, comprising one or more goals, of a current activity of the user, reasoning, based on the task understanding and a user's current state, a next step for advancing the user towards completing one of the one or more goals of the task understanding and overlaying the scene with an augmented reality view comprising one or more visual and audio representation of the next step to the user.

Abstract: A method includes receiving, at a model and optimization framework, a request, rendered in a first format, for a service to be implemented on a subset of a software-defined network. The request includes at least one constraint affecting implementation of the service. The method includes producing an optimized solution, rendered in a second format, for implementing the service based on the at least one constraint. The method includes translating the optimized solution to the first format and providing instructions for a cloud manager to implement the service consistent with the translated optimized solution.

Abstract: The present disclosure provides immunomodulatory compositions comprising heat-killed Caulobacter crescentus (HKCC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising HKCC to the individual.