Abstract: A method and system for providing a data analytics platform that facilitates efficient feature delivery based on reusability of software modules are provided. The method includes receiving a job request that corresponds to a feature desired by a user; transforming the job request into a directed acyclic graph (DAG) that includes a set of operations; and constructing a software program that is configured to execute the set of operations included in the DAG. The transformation is performed by extracting a set of configuration instructions that respectively correspond to operations included in the set of operations from the job request. The construction of the software program is performed by retrieving software modules that are configured to execute operations included in the DAG from a library that stores a plurality of reusable software modules that respectively correspond to algorithm functions.

Abstract: Various methods, apparatuses/systems, and media for implementing a payment application module for searching billets are disclosed. A plurality of data sources include customer profile data, customer payment history data, biller information data, and biller directory data. A processor operatively coupled to the plurality of data sources via a communication network builds a customer profile service area popularity model based on the customer profile data, customer payment history data, biller information data, and biller directory data; receives search query data for searching a biller; builds a biller search machine learning model to optimize weights applied to the search query data; and ranks search results by utilizing the machine learning model in response to the search query data.

Abstract: Various methods, apparatuses/systems, and media for implementing a payment application module for searching billets are disclosed. A plurality of data sources include customer profile data, customer payment history data, biller information data, and biller directory data. A processor operatively coupled to the plurality of data sources via a communication network builds a customer profile service area popularity model based on the customer profile data, customer payment history data, biller information data, and biller directory data; receives search query data for searching a biller; builds a biller search machine learning model to optimize weights applied to the search query data; and ranks search results by utilizing the machine learning model in response to the search query data.

Abstract: Disclosed herein are prodrugs of platinum containing anticancer agents such as cisplatin that contain an alkylating moiety. Upon administration, the prodrugs release the platinum containing anticancer agent and the alkylating agent, which can form an adduct with DNA or can protect the platinum containing agent from removal. The disclosed prodrugs can be used to treat various cancers, including cisplatin resistant cancers.

Abstract: Described is a targeted molecular scaffold for construction of a metabolic inhibitor loaded with cancer-cell specific activity and anti-tumor immunity. Incorporation of a mitochondria targeting moiety such as triphenylphosphonium cation through a biodegradable linker in allowed for mitochondria targeting of certain metabolic inhibitors like dichloroacetic acid (DCA).

Abstract: Pt(IV) compounds include a mitochondria targeting moiety. One example of a Pt(IV) compound having a mitochondria targeting moiety is a Pt(IV) cisplatin-based compound. Upon reduction, the mitochondrial targeting moieties are released resulting in a Pt(II) therapeutic agent. Pt(IV) compounds including a mitochondria targeting moiety can be included in nanoparticles. The compounds or nanoparticles can be used to treat, for example, cancer.

Abstract: Disclosed herein are prodrugs of platinum containing anticancer agents such as cisplatin that contain an alkylating moiety. Upon administration, the prodrugs release the platinum containing anticancer agent and the alkylating agent, which can form an adduct with DNA or can protect the platinum containing agent from removal. The disclosed prodrugs can be used to treat various cancers, including cisplatin resistant cancers.

Abstract: Pt(IV) prodrugs include one or more conjugated cyclooxygenase inhibitor. Reduction of Pt(IV) to Pt(II) can result cisplatin and a cyclooxygenase inhibitor. For proof of concept, a Pt(IV) prodrug that can produce cisplatin and aspirin, Platin-A, was synthesized. Platin-A exhibited excellent anticancer and anti-inflammatory properties, which were better than the combination of free formulation of cisplatin and aspirin.

Abstract: Reactions of 1,3-dipole-functional (e.g., azide-functional) platinum(IV) compounds with cyclic alkynes under conditions effective for a cycloaddition reaction to form a heterocyclic compound are disclosed herein. In certain embodiments, the conditions effective for the cycloaddition reaction to form the heterocyclic compound includes the substantial absence of added catalyst (e.g., copper catalyst).

Abstract: Pt(IV) compounds include a mitochondria targeting moiety. One example of a Pt(IV) compound having a mitochondria targeting moiety is a Pt(IV) cisplatin-based compound. Upon reduction, the mitochondrial targeting moieties are released resulting in a Pt(II) therapeutic agent. Pt(IV) compounds including a mitochondria targeting moiety can be included in nanoparticles. The compounds or nanoparticles can be used to treat, for example, cancer.

Abstract: Pt(IV) prodrugs include one or more conjugated cyclooxygenase inhibitor. Reduction of Pt(IV) to Pt(II) can result cisplatin and a cyclooxygenase inhibitor. For proof of concept, a Pt(IV) prodrug that can produce cisplatin and aspirin, Platin-A, was synthesized. Platin-A exhibited excellent anticancer and anti-inflammatory properties, which were better than the combination of free formulation of cisplatin and aspirin.

Abstract: The present invention relates to a kit and a method to identify M. tuberculosis, which may include an approach relating to isolating chromosomal DNA from a biological sample, such as a culture, conducting a real time PCR to obtain an amplicon, digesting said amplicon separately with restriction enzymes NruI and BamHI to obtain a digestion product separating said digestion product into its constituents in a gel; and analyzing the restriction enzyme digestion pattern.