Patents by Inventor Rakesh Paul

Rakesh Paul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ribosome-Mediated Incorporation of Peptides and Peptidomimetics
    Publication number: 20230046194
    Abstract: Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.
    Type: Application
    Filed: July 19, 2022
    Publication date: February 16, 2023
    Applicant: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Sidney Hecht, Larisa (Liza) Dedkova, Rumit Maini, Sandipan Roy Chowdhury, Rakesh Paul
  • Ribosome-mediated incorporation of peptides and peptidomimetics
    Patent number: 11434492
    Abstract: Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: September 6, 2022
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Sidney Hecht, Larisa (Liza) Dedkova, Rumit Maini, Sandipan Roy Chowdhury, Rakesh Paul
  • Ribosome-Mediated Incorporation of Peptides and Peptidomimetics
    Publication number: 20200370057
    Abstract: Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.
    Type: Application
    Filed: June 29, 2020
    Publication date: November 26, 2020
    Applicant: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Sidney Hecht, Larisa (Liza) Dedkova, Rumit Maini, Sandipan Roy Chowdhury, Rakesh Paul
  • Ribosome-mediated incorporation of peptides and peptidomimetics
    Patent number: 10745705
    Abstract: Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: August 18, 2020
    Assignee: ARIZON BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Sidney Hecht, Larisa (Liza) Dedkova, Rumit Maini, Sandipan Roy Chowdhury, Rakesh Paul
  • DNA polymerase beta inhibitors
    Patent number: 10711027
    Abstract: Methods and compounds are disclosed for irreversibly inhibiting a DNA repair enzyme that possesses lyase activity.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: July 14, 2020
    Assignee: The Johns Hopkins University
    Inventors: Marc M. Greenberg, Rakesh Paul
  • DNA POLYMERASE BETA INHIBITORS
    Publication number: 20190202853
    Abstract: Methods and compounds are disclosed for irreversibly inhibiting a DNA repair enzyme that possesses lyase activity.
    Type: Application
    Filed: August 11, 2017
    Publication date: July 4, 2019
    Inventors: Marc M. Greenberg, Rakesh Paul
  • Saccharide conjugates
    Patent number: 10046068
    Abstract: This invention relates to compounds comprising a saccharide conjugated to an imaging agent or a reporter group, compositions comprising them and methods of using them. Specifically BLM-disaccharide and BLM-monosaccharide conjugates containing different linker groups and an imaging agent or a reporter group are provided for the targeting and imaging of tumors.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 14, 2018
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Sidney Hecht, Manikandadas Mathilakathu Madathil, Chandrabali Bhattacharya, Trevor Bozeman, Rakesh Paul, Zhiqiang Yu, Michael J. Rishel
  • Sugar-linker-drug conjugates
    Patent number: 9919055
    Abstract: The present disclosure relates to sugar-linker-drug conjugates, of the formula [A-B-]n-L-D, wherein A is a saccharide; B is a spacer, n is an integer selected from 1 to 3; L is a linker group and D is a drug having a chemically reactive functional group selected from the group consisting of a primary or secondary amine, hydroxyl, sulfhydryl, carboxyl, aldehyde and ketone. Pharmaceutical compositions comprising the conjugates and methods of using them are also provided.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 20, 2018
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Sidney Hecht, Rakesh Paul, Chenhong Tang, Manikandadas Mathilakathu Madathil, Chandrabali Bhattacharya
  • RIBOSOME-MEDIATED INCORPORATION OF PEPTIDES AND PEPTIDOMIMETICS
    Publication number: 20180002709
    Abstract: Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.
    Type: Application
    Filed: January 22, 2016
    Publication date: January 4, 2018
    Applicant: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Sidney HECHT, Larisa (Liza) DEDKOVA, Rumit MAINI, Sandipan ROY CHOWDHURY, Rakesh PAUL
  • SUGAR-LINKER-DRUG CONJUGATES
    Publication number: 20160045611
    Abstract: The present disclosure relates to sugar-linker-drug conjugates, of the formula [A-B-]n-L-D, wherein A is a saccharide; B is a spacer, n is an integer selected from 1 to 3; L is a linker group and D is a drug having a chemically reactive functional group selected from the group consisting of a primary or secondary amine, hydroxyl, sulfhydryl, carboxyl, aldehyde and ketone. Pharmaceutical compositions comprising the conjugates and methods of using them are also provided.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 18, 2016
    Inventors: Sidney Hecht, Rakesh Paul, Chenhong Tang, Manikandadas Mathilakathu Madathil, Chandrabali Bhattacharya
  • SACCHARIDE CONJUGATES
    Publication number: 20160038615
    Abstract: This invention relates to compounds comprising a saccharide conjugated to an imaging agent or a reporter group, compositions comprising them and methods of using them. Specifically BLM-disaccharide and BLM-monosaccharide conjugates containing different linker groups and an imaging agent or a reporter group are provided for the targeting and imaging of tumors.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 11, 2016
    Inventors: Sidney Hecht, Manikandadas Mathilakathu Madathil, Chandrabali Bhattacharya, Trevor Bozeman, Rakesh Paul, Zhiqiang Yu, Michael J. Rishel