Abstract: Provided is a system for contextual and positional parameterized record building. The system provides a mechanism to track any data record, information element or its parts to extract graphical/logical and contextual location in source documents and construct a data tree representation using a data representation module. The information extraction is enabled by a learning approach that incorporates graphical positional features into the model building process. A prediction architecture includes a gate network having a plurality of gates/neurons. Each gate/neuron is associated with an activation function based on a pre-built logic to perform a specific operation and operates on signals received at the gate/neuron. A record building module constructs one or more records based on candidate data values derived from the data tree representation using the prediction architecture. The candidate data values are wrapped in signals and fed to gates/neurons to construct the one or more records.

Abstract: An upper limb prosthetic device may comprise a hybrid-drive prosthetic device that includes one or more actuators fixed to a first arm portion and one or more cables extending from the one or more actuators along one or more cable paths defined through the first arm portion and a second arm portion to a terminal device/device assembly, where the one or more cables are configured to be actuated by the one or more actuators and are further configured to be actuated by pivoting the second arm portion toward the first arm portion, Alternatively, or additionally, the upper limb prosthetic device may comprise a modular prosthetic device that includes a modular terminal device assembly with removably coupled first, second, and third modular links configured to control the respective yaw, pitch, and roll of an end effector (e.g a prosthetic hand, a tool, an instrument or any other attachment).

Abstract: The invention includes compositions and methods for treating cancer comprising administering to a subject in need a pharmaceutically effective dose of a cancer stem cell inhibitor, methods of inhibiting the growth of cancer stem cells or tumor initiating cell comprising administering to a subject in need a pharmaceutically effective amount of a pharmaceutical composition for inhibiting cancer stem cells. The pharmaceutical composition includes various combinations of sulforaphane, resveratrol, mangostine, honokiol, diallyltrisulphide and gemcitabine.

Abstract: This invention describes a series of methods and compositions for prevention and treatment of diseases such as cancer. One aspect of the invention describes small molecule-based drugs that can be used to bind to death receptors TRAIL-R1/DR4 and/or TRAIL-R2/DR5 and induce apoptosis in cancer cells, while sparing normal cells. The invention also describes TRAIL Death Receptor Agonists/Activators (DRAs) and their uses, such as the induction of apoptosis through caspase-8 and caspase-3 activation. The present invention also describes the methods of treating cancers, such as breast, prostate, colon, pancreatic, ovarian, lung, and brain cancers, leukemia, lymphoma, multiple myeloma, and mesothelioma, using DRAs either as single-agent treatments, or in combination with other therapies.

Abstract: This invention describes a series of methods and compositions for prevention and treatment of diseases such as cancer. One aspect of the invention describes small molecule-based drugs that can be used to bind to death receptors TRAIL-R1/DR4 and/or TRAIL-R2/DR5 and induce apoptosis in cancer cells, while sparing normal cells. The invention also describes TRAIL Death Receptor Agonists/Activators (DRAs) and their uses, such as the induction of apoptosis through caspase-8 and caspase-3 activation. The present invention also describes the methods of treating cancers, such as breast, prostate, colon, pancreatic, ovarian, lung, and brain cancers, leukemia, lymphoma, multiple myeloma, and mesothelioma, using DRAs either as single-agent treatments, or in combination with other therapies.