Abstract: Disclosed are transfecting agents for delivery of nucleic acids (e.g., DNA, plasmids, oligos, small interfering RNAs [siRNA], small hairpin RNA [shRNA], microRNAs [miRNA], Clustered Regularly Interspaced Short Palindromic Repeats [CRISPR]) or proteins (phosphoproteins, enzymes, antibodies, vaccines) using a peptide-based, pegylated peptide-based, a peptide attached to a lipophilic moiety (lipidated peptides), or lipophilic pegylated peptides to living cells.

Abstract: A plurality of log records characterizing operations occurring within a technology landscape may be received. The plurality of log records may be clustered into at least a first cluster of log records and a second cluster of log records, using at least one similarity algorithm. A first dissimilar subset of log records within the first cluster of log records, and a second dissimilar subset of log records within the second cluster of log record may be identified, using the at least one similarity algorithm. At least one machine learning model may be trained to process new log records characterizing the operations occurring within the technology landscape, using the first dissimilar subset and the second dissimilar subset.

Abstract: Provided herein are drug delivery systems comprising a peptide targeting agent and a pharmaceutical agent for delivery of chemotherapeutic agents. Also provided are methods of treating cancer comprising administration of the drug delivery system disclosed herein.

Abstract: According to one general aspect, a non-transitory computer readable medium includes instructions that, when executed by at least one processor, cause a computing device to read a string of a log file for an application, where the log file comprises multiple strings of log data, compare the string to signatures stored in a memory to find a matching signature, where each of the signatures is encoded with a signature identifier (ID), determine a deviation between the string and the matching signature, encode the string with the signature identifier (ID) of the matching signature and the deviation, and transfer the string to a destination computing device using the signature identifier (ID) of the matching signature, the deviation, and a timestamp of the string.

Abstract: Antiviral compounds, pharmaceutical compositions containing the same, and methods of treating viral infections or medical disorders resulting from viral infections are disclosed.

Abstract: Peptide-based systems containing hydrophobic amino acids (e.g., tryptophan), charged amino acids (e.g., arginine), and/or sulfur-containing amino acids (e.g., cysteine), which can be used either alone or in combination with nanoparticles (e.g., gold or silver nanoparticles) for siRNA delivery into living cells are disclosed.

Abstract: According to one general aspect, a non-transitory computer readable medium includes instructions that, when executed by at least one processor, cause a computing device to read a string of a log file for an application, where the log file comprises multiple strings of log data, compare the string to signatures stored in a memory to find a matching signature, where each of the signatures is encoded with a signature identifier (ID), determine a deviation between the string and the matching signature, encode the string with the signature identifier (ID) of the matching signature and the deviation, and transfer the string to a destination computing device using the signature identifier (ID) of the matching signature, the deviation, and a timestamp of the string.

Abstract: Synthetic peptides comprising a sequence of amino acids XnVm, wherein X represents positively charged amino acid, Y represents hydrophobic amino acid, and both n and m are greater than 2 are disclosed. In accordance with the purposes of the disclosed compositions and methods, as embodied and broadly described herein, the disclosed subject matter relates to synthetic antimicrobial peptides and methods of making and using same.

Abstract: Provided herein are drug delivery systems comprising a peptide targeting agent and a pharmaceutical agent for delivery of chemotherapeutic agents. Also provided are methods of treating cancer comprising administration of the drug delivery system disclosed herein.

Abstract: The present invention relates to a novel process for the preparation of lifitegrast of Formula I. The present invention further provides a novel process for the purification of lifitegrast of Formula I.

Abstract: The present invention relates to a novel process for the preparation of lifitegrast of Formula I. The present invention further provides a novel process for the purification of lifitegrast of Formula I.

Abstract: A system and method are provided for grouping customers from a pool of customers of a financial institution to subsequently receive advertisements.

Abstract: The present invention relates to an improved process for the preparation of Apixaban and intermediates thereof. Further the present invention also relates to novel intermediate of Formula V and its process for the preparation.

Abstract: A computer-implemented method and system are provided for communicating advertisement materials to a user. In one aspect, the method includes: receiving identifier data and location data from a mobile device of the user; retrieving a profile of the user from a user database based on the identifier data, the user profile including historical spending data of the user and/or a user categorization; determining a set of advertisement materials for communication to the user, including: searching an advertisement database of advertisement materials based on the location data and user profile, each advertisement material having a predetermined set of conditions associated therewith; and selecting the set of advertisement materials based on results of the search, wherein the location data and user profile match the predetermined set of conditions of the selected set; and communicating at least one advertisement material from the selected set to the mobile device of the user.

Abstract: A computer implemented method of analyzing transaction data relating to electronic commerce is provided which comprises: receiving, in an electronic commerce analysis server, first transaction data indicating transactions made by payment cards of a first payment card type; identifying, in the electronic commerce analysis server, first electronic commerce transactions in the first transaction data; calculating, in the electronic commerce analysis server, an electronic commerce metric for the first payment card type using the first electronic commerce transactions; receiving, in the electronic commerce analysis server, first electronic billing information for the payment cards of the first payment card type; calculating, in the electronic commerce analysis server, an electronic billing metric for the first payment card type using the first electronic billing information; and determining, in the electronic commerce analysis server, a composite metric for the first payment card type from the calculated electronic

Abstract: A computer implemented method of identifying and classifying customer segments is disclosed. The method comprises: receiving customer purchase history data for a plurality of payment cards of a payment card account type associated with a merchant organization, the customer purchase history data comprising indications of transactions carried out by customers using the payment cards of the payment card account type at the merchant organization; grouping the customers into a plurality of customer segments using the purchase history data; receiving payment card accounting data for the payment card account type, the payment card accounting data comprising indications of accounting data associated with the payment card account type; calculating a revenue value for each customer segment of the plurality of customer segments; and classifying the customer segments according to the revenue value.

Abstract: A computer implemented method of assessing a potential location for an automated teller machine is disclosed.

Abstract: A computer implemented method for predicting dynamic pricing for a product or service is disclosed. The method comprises: receiving, at a server, transaction data for a plurality transactions relating to the product or service, the transaction data comprising transaction information indicating attributes of the transaction and booking information indicating attributes of the product or service; storing the transaction data on the server as a data set; calculating, in a derived variable calculation module of the server, derived variables for the data set from the transaction information and/or the booking information; generating, in a model generation module of the server, a model for the price of the product or service as a function of the derived variables; and predicting, in a price prediction module of the server, a price for the product or service using the model.

Abstract: A computerised method for managing travel expenditure is disclosed. The method comprises: receiving travel data for a traveller's proposed trip, the travel data comprising at least a travel budget and travel destination; receiving a user profile comprising at least an indication of spend level preference for the traveller; obtaining historic travel expenditure data for a plurality of customers; analysing the historic travel expenditure data in light of the travel data and user profile to determine an optimal proposed spend allocation for the traveller across different travel spend streams; and communicating the proposed spend allocation to the traveller along with a listing of potential merchants for each spend stream, the potential merchants being extracted from the historic travel expenditure data.

Abstract: The present invention relates to an improved process for the preparation of Apixaban and intermediates thereof. Further the present invention also relates to novel intermediate of Formula V and its process for the preparation.