Patents by Inventor Rakhi Rajan

Rakhi Rajan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA-DIRECTED DNA CLEAVAGE AND GENE EDITING BY CAS9 ENZYME FROM NEISSERIA MENINGITIDIS
    Publication number: 20240067982
    Abstract: Disclosed are components and methods for RNA-directed DNA cleavage and gene editing. The components include and the methods utilize a Cas9 protein from Neisseria and one or more RNA molecules in order to direct the Cas9 protein to bind to and optionally cleave or nick a target sequence.
    Type: Application
    Filed: November 23, 2022
    Publication date: February 29, 2024
    Inventors: Erik J. Sontheimer, Yan Zhang, Alfonzo Mondragon, Rakhi Rajan, James Thomson, Zhonggang Hou
  • Variant CAS12 proteins with improved dna cleavage selectivity and methods of use
    Patent number: 11459552
    Abstract: Bridge helix-modified variant Cas12a and Cas12b proteins having improved DNA cleavage selectivity in comparison to wild type versions of the Cas12a and Cas12b proteins, nucleic acids encoding the variant proteins, host cells containing the nucleic acids, and methods of their use.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: October 4, 2022
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Rakhi Rajan
  • VARIANT CAS12 PROTEINS WITH IMPROVED DNA CLEAVAGE SELECTIVITY AND METHODS OF USE
    Publication number: 20220213459
    Abstract: Bridge helix-modified variant Cas12a and Cas12b proteins having improved DNA cleavage selectivity in comparison to wild type versions of the Cas12a and Cas12b proteins, nucleic acids encoding the variant proteins, host cells containing the nucleic acids, and methods of their use.
    Type: Application
    Filed: March 25, 2022
    Publication date: July 7, 2022
    Inventor: Rakhi Rajan
  • Variant CAS9 proteins with improved DNA cleavage selectivity
    Patent number: 11124783
    Abstract: Bridge helix-modified variant Cas9 proteins having improved DNA cleavage selectivity in comparison to wild type versions of the Cas9 proteins, nucleic acids encoding the variant proteins, host cells containing the nucleic acids, and methods of their use.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: September 21, 2021
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Rakhi Rajan
  • VARIANT CAS12 PROTEINS WITH IMPROVED DNA CLEAVAGE SELECTIVITY AND METHODS OF USE
    Publication number: 20200332275
    Abstract: Bridge helix-modified variant Cas12a and Cas12b proteins having improved DNA cleavage selectivity in comparison to wild type versions of the Cas12a and Cas12b proteins, nucleic acids encoding the variant proteins, host cells containing the nucleic acids, and methods of their use.
    Type: Application
    Filed: July 1, 2020
    Publication date: October 22, 2020
    Inventor: Rakhi Rajan
  • VARIANT CAS9 PROTEINS WITH IMPROVED DNA CLEAVAGE SELECTIVITY
    Publication number: 20200087639
    Abstract: Bridge helix-modified variant Cas9 proteins having improved DNA cleavage selectivity in comparison to wild type versions of the Cas9 proteins, nucleic acids encoding the variant proteins, host cells containing the nucleic acids, and methods of their use.
    Type: Application
    Filed: September 13, 2019
    Publication date: March 19, 2020
    Inventor: Rakhi Rajan
  • RNA-DIRECTED DNA CLEAVAGE AND GENE EDITING BY CAS9 ENZYME FROM NEISSERIA MENINGITIDIS
    Publication number: 20140349405
    Abstract: Disclosed are components and methods for RNA-directed DNA cleavage and gene editing. The components include and the methods utilize a Cas9 protein from Neisseria and one or more RNA molecules in order to direct the Cas9 protein to bind to and optionally cleave or nick a target sequence.
    Type: Application
    Filed: May 22, 2014
    Publication date: November 27, 2014
    Applicants: WISCONSIN ALUMNI RESEARCH FOUNDATION, NORTHWESTERN UNIVERSITY
    Inventors: Erik J. Sontheimer, Yan Zhang, Alfonso Mondragon, Rakhi Rajan, James Thomson, Zhonggang Hou