Abstract: A computer implemented method and system for fully-automatic cardiac functional assessment are provided. Automatic segmentation of a series of ultrasonic cardiac images is performed for delineating an endocardium boundary and an epicardium boundary, in each of the ultrasonic cardiac images using a segmentation algorithm. Multiple acoustic markers are identified on the endocardium boundary on the ultrasonic cardiac images. The acoustic markers are tracked across the ultrasonic cardiac images over multiple cardiac cycles using a tracking algorithm. Multiple cardiac parameters are calculated using the tracked acoustic markers on drift compensated ultrasonic cardiac images. The computer implemented method and system for cardiac functional assessment is fully-automatic without requiring user intervention or inputs.