Patents by Inventor Raleigh Carmen
Raleigh Carmen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7083910Abstract: Methods and compositions for preserving blood platelet suspensions which can be stored and preserved for extended periods of time are provided herein. The methods and compositions employ a mixture comprising blood platelets and one or more citrate salts. Such blood platelet mixtures may be cooled either rapidly or slowly and stored for several days prior to use in patients.Type: GrantFiled: August 4, 2004Date of Patent: August 1, 2006Assignee: Human BiosystemsInventors: David Lucas, Raleigh Carmen
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Publication number: 20050064381Abstract: Methods and compositions for preserving blood platelet suspensions which can be stored and preserved for extended periods of time are provided herein. The methods and compositions employ a mixture comprising blood platelets and one or more citrate salts. Such blood platelet mixtures may be cooled either rapidly or slowly and stored for several days prior to use in patients.Type: ApplicationFiled: August 4, 2004Publication date: March 24, 2005Inventors: David Lucas, Raleigh Carmen
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Patent number: 6060138Abstract: Improved flexible film and tubing for medical products manufactured from a PVC compound, comprising an amount of ultra high molecular weight (UHMW) PVC resin having an inherent viscosity ranging from about 1.25 to about 2.00, most preferably about 1.71, and about 43 to about 57 percent by weight of a medically acceptable plasticizer, most preferably about 53 percent, such as tri (2-ethylhexyl) trimellitate (TOTM).Type: GrantFiled: July 27, 1999Date of Patent: May 9, 2000Assignee: Pall CorporationInventors: Raleigh A. Carmen, Ronald H. Bauman
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Patent number: 5968619Abstract: Improved flexible film and tubing for medical products manufactured from a PVC compound, comprising an amount of ultra high molecular weight (UHMW) PVC resin having an inherent viscosity ranging from about 1.25 to about 2.00, most preferably about 1.71, and about 43 to about 57 percent by weight of a medically acceptable plasticizer, most preferably about 53 percent, such as tri (2-ethylhexyl) trimellitate (TOTM).Type: GrantFiled: November 25, 1997Date of Patent: October 19, 1999Inventors: Raleigh A. Carmen, Ronald H. Bauman
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Patent number: 5769839Abstract: System and method for storing packed red blood cells (RBCs) long-term in a non-extractable plastic blood storage bag in a hypotonic cell preservation solution, for subsequent human parenteral introduction of the stored red blood cells. In addition, a blood storage bag that contains a volume of blood product, such as packed red blood cells, that have hemolyzed less than 1% during at least 42 days storage in a non-extractable plastic storage bag containing a volume of hypotonic cell preservation solution.Type: GrantFiled: September 5, 1996Date of Patent: June 23, 1998Assignee: PALL CorporationInventors: Raleigh A. Carmen, Chi Yong Chong, Randy B. Garcez
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Patent number: 5721024Abstract: Improved flexible film and tubing for medical products manufactured from a PVC compound, comprising an amount of ultra high molecular weight (UHMW) PVC resin having an inherent viscosity ranging from about 1.25 to about 2.00, most preferably about 1.71, and about 43 to about 57 percent by weight of a medically acceptable plasticizer, most preferably about 53 percent, such as tri (2-ethylhexyl) trimellitate (TOTM).Type: GrantFiled: June 7, 1995Date of Patent: February 24, 1998Assignee: Pall CorporationInventors: Raleigh A. Carmen, Ronald H. Bauman
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Patent number: 5240829Abstract: A closed system for inactivating viruses in blood or blood components. The system includes at least one plastic bag which communicates with a separate container including a single viricidal substance or separate substances which, when mixed, provide in situgeneration of a viricidal substance. The viricidal substance can be transferred into the bag for subsequent viricidal use on blood components or for use on components in the bag. A preferred system provides a means for the in-situ generation of ClO.sub.2 from sterilizable, separate substances for viricidal use on blood or blood components.Type: GrantFiled: February 10, 1989Date of Patent: August 31, 1993Assignee: Miles Inc.Inventors: Raleigh Carmen, Chi-Yong Chong
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Patent number: 5236716Abstract: Platelet concentrate containing less then 10.sup.6 white blood cells and prepared from a unit of whole blood sample in a closed multiple blood bag system within less than about eight hours after the whole blood is removed from a human. The concentrate is contained in a platelet storage bag made from polyvinyl chloride plasticized with either trioctyltrimellitate or ethylene vinyl acetate.Type: GrantFiled: February 14, 1992Date of Patent: August 17, 1993Assignee: Miles Inc.Inventors: Raleigh A. Carmen, Edward J. Nelson
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Patent number: 5102407Abstract: Blood bag system for separating whole blood into upper, middle, and lower components which can then be isolated from each other in an automated manner. The system comprises a primary or main blood bag having first and second outlet ports. The first outlet port communicates via tubing with a first satellite bag. The second outlet port communicates via tubing with a second satellite bag at one end and at the other end communicates with a tubular member extending into and toward the bottom of the main bag. In use whole blood is drawn into the main bag through an inlet port and centrifuged to form an upper, less dense plasma portion, a lower, more dense red blood cell (RBC) portion and an intermediate portion of buffy coat (including platelets). Pressure is then applied to the bag with the first outlet open and the second outlet closed to express all of the upper plasma through the first outlet port after which the first outlet port is closed and the second outlet is opened.Type: GrantFiled: March 13, 1990Date of Patent: April 7, 1992Assignee: Miles Inc.Inventors: Raleigh A. Carmen, Willie J. Lewis, Eva Sajan
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Patent number: 5089146Abstract: Filtration of white blood cells (WBCs) directly from platelet rich plasma (PRP) rather than from subsequently made platelet concentrates (PC). Earlier filtration is effective at removing most WBCs with minimal platelet loss and permits storage of platelets for at least 5 days. The filtration is preferably done with a closed, ready-to-use system comprising a WBC filter disposed between a first blood bag and at least two empty secondary bags. A fourth bag may be included in the closed system to contain a platelet additive solution. System can remove at least 95% of the WBCs with less than 10% loss in platelets. In very preferred embodiments at least 99.5% of the original WBCs are removed by filtration prior to platelet storage.Type: GrantFiled: February 12, 1990Date of Patent: February 18, 1992Assignee: Miles Inc.Inventors: Raleigh A. Carmen, Edward J. Nelson
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Patent number: 4994057Abstract: An improved heat sterilizable blood bag system adapted for containing and mixing of different materials originally placed in separate but potentially communicating compartments. The improvement comprises of having a smaller squeezable compartment for one material attached to and capable of communicating with a larger compartment for the other material. The material in the smaller compartment is separated from the interior of the larger compartment by means of an externally manipulatable closure means which, when opened, permits mixture of the contents in the first compartment and contents of the second compartment when the smaller compartment is repeatedly squeezed.Type: GrantFiled: November 6, 1989Date of Patent: February 19, 1991Assignee: Miles Inc.Inventors: Raleigh A. Carmen, Chi-Yong Chong
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Patent number: 4969882Abstract: A generally flat, elongated edge-sealed polymeric blood bag having a length to width ratio of at least 2 to 1 and one end portion in tapering communication with a connected tubing. When the bag is filled with a mixture of blood components which are then separated, the tapering end portion expands to form a funnel-like guide for directing a separated component from the bag through the tubing in a substantially unobstructed manner. Bag is especially useful for separating and isolating the components of a neocyte/gerocyte red blood cell mixture.Type: GrantFiled: June 27, 1986Date of Patent: November 13, 1990Assignee: Miles Laboratories, Inc.Inventors: Raleigh A. Carmen, Barry S. Leng, Willie J. Lewis, Edward J. Nelson
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Patent number: 4943287Abstract: Closed blood bag system for long term storage of red blood cells (RBCs) without contamination due to storage. System comprises the combination of a white blood cell (WBC) filter in sterile communication with a plastic bag made from a film substantially free of blood extractable plasticizers. In use, an RBC preservative solution (preferably from within the closed system) is added to a mixture of RBCs and WBCs and the mixture is then passed through the filter to remove at least 98% of the WBCs. The filtered RBCs and preservative solution pass into the attached bag and can then be stored in the attached bag for up to 42 days.Type: GrantFiled: July 17, 1989Date of Patent: July 24, 1990Assignee: Miles Inc.Inventor: Raleigh A. Carmen
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Patent number: 4915848Abstract: Closed filtering system for relatively fast and efficient removal of white blood cells from a red blood cell mixture. System comprises at least two blood bags in closed communication with each other via an intermediate filter assembly comprising a housing containing continuous filtering fiber. A preferred housing is tapered and the fiber preferably has a generally Y-shaped cross sectional area and it is adapted to permit substantial removal of white blood cells from a red blood cell mixture with minimal red blood cell hemolysis when the mixture is diluted with preservative solution and passed from one bag to the other at a relatively high flow rate. Filtration is completed within 24 hours, preferably within 6 hours, of whole blood donation.Type: GrantFiled: January 31, 1989Date of Patent: April 10, 1990Assignee: Miles Laboratories, Inc.Inventors: Raleigh A. Carmen, Chiyong Chong, Barry S. Leng
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Patent number: 4902287Abstract: An improved heat sterilizable blood bag system adapted for containing and mixing of different materials originally placed in separate but potentially communicating compartments. The improvement comprises of having a smaller squeezable compartment for one material attached to and capable of communicating with a larger compartment for the other material. The material in the smaller compartment is separated from the interior of the larger compartment by means of an externally manipulatable closure means which, when opened, permits mixture of the contents in the first compartment and contents of the second compartment when the smaller compartment is repeatedly squeezed.Type: GrantFiled: September 24, 1987Date of Patent: February 20, 1990Assignee: Miles Inc.Inventors: Raleigh A. Carmen, Chi-Yong Chong
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Patent number: 4892537Abstract: A generally flat, elongated edge-sealed polymeric blood bag having a length to width ratio of at least 2 to 1 and one end portion in tapering communication with a connected tubing. When the bag is filled with a mixture of blood components which are then separated, the tapering end portion expands to form a funnel-like guide for directing a separated component from the bag through the tubing in a substantially unobstructed manner. Bag is especially useful for separating and isolating the components of a neocyte/gerocyte red blood cell mixture.Type: GrantFiled: February 11, 1985Date of Patent: January 9, 1990Assignee: Miles Laboratories, Inc.Inventors: Raleigh A. Carmen, Barry S. Leng, Willie J. Lewis, Edward J. Nelson
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Patent number: 4855063Abstract: Closed filtering system for relatively fast and efficient removal of white blood cells from a red blood cell mixture. System comprises at least two blood bags in closed communication with each other via an intermediate filter assembly comprising a housing containing continuous filtering fiber. A preferred housing is tapered and the fiber preferably has a generally Y-shaped cross sectional area and it is adapted to permit substantial removal of white blood cells from a red blood cell mixture with minimal red blood cell hemolysis when the mixture is diluted with perservative solution and passed from one bag to the other at a relatively high flow rate. Filtration is completed within 24 hours, preferably within 6 hours, of whole blood donation.Type: GrantFiled: April 21, 1986Date of Patent: August 8, 1989Assignee: Miles Laboratories, Inc.Inventors: Raleigh A. Carmen, Chiyong Chong, Barry S. Leng
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Patent number: 4810378Abstract: Closed filtering system for relatively fast and efficient removal of white blood cells from a red blood cell mixture. System comprises at least two blood bags in closed communication with each other via an intermediate filter assembly comprising a housing containing continuous filtering fiber. A preferred housing is tapered and the fiber preferably has a generally Y-shaped cross sectional area and it is adapted to permit substantial removal of white blood cells from a red blood cell mixture with minimal red blood cell hemolysis when the mixture is diluted with preservative solution and passed from one bag to the other at a relatively high flow rate. Filtration is completed within 24 hours, preferably within 6 hours, of whole blood donation.Type: GrantFiled: May 26, 1987Date of Patent: March 7, 1989Assignee: Miles Laboratories, Inc.Inventors: Raleigh A. Carmen, Chiyong Chong, Barry S. Leng
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Patent number: 4609372Abstract: Aqueous storage solution for red blood cells comprising a stabilized ascorbate derivative and having a pH sufficient to maintain substantially all of the initial concentration of ascorbate derivative and avoid formation of ascorbate degradation products during heat sterilization. A preferred solution includes at least about 90% of the pre-sterilization ascorbate and adenine but is free of dextrose.Type: GrantFiled: October 13, 1983Date of Patent: September 2, 1986Assignee: Miles Laboratories, Inc.Inventors: Raleigh A. Carmen, Chiyong Chong, Barry Leng